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Brain imaging before and after Covid-19 in UK Biobank

medrxiv.org

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Re: Brain imaging before and after Covid-19 in UK Biobank

#121

Post by ch4s3 »

krona wrote: post #90
ch4s3 wrote: post #67

Earlier quoted context omitted.

> until more is known about long term effects I'm curious about this line of reasoning. We've been testing mRNA treatments for other diseases for about 25 years now. The approach was abandoned for gene therapy because the effects weren't long lasting. We have follow up data on people who participated in those studies, and to my knowledge there aren't any documented negative long term effects. We know what the vaccine…

The other ingredients in the vaccine aren't anything special. Polyethylene glycol, for one, has never been used before in an approved vaccine. It is thought to be the cause of some rare anaphylactic reactions. There are dozens of other compounds in the Pfizer vaccine; the reason for them being there and their effects are, for the most part, a trade secret.

It seems like the amount of PEG in the vaccine is two orders of magnitude than the levels in existing drugs[1].

[1] https://www.sciencemag.org/news/2020/12/suspicions-grow-nano...

Re: Brain imaging before and after Covid-19 in UK Biobank

#122

Post by peter422 »

throwkeep wrote: post #108
JohnJamesRambo wrote: post #4

I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?

There are valid concerns and a difficult risk benefit analysis for some cohorts, I think. What are your thoughts on this? Put yourself in her shoes: "I held off on a COVID vaccine because I wanted to wait for data with positive signals for both pregnancy in the short term and long-run fertility. I’m trying to get pregnant, and those are the two things I care about most. Vaccine data is so politicized that it’s actual…

The vaccines did not skip any safety tests, they just compressed the schedule because millions of people were dying of a preventable disease.

At this point hundreds of millions of people have taken the various vaccines. There clearly are no major short or medium term effects (other than the reported, rare side effects).

Also you can literally read all the documents provided to the FDA concerning the efficacy and safety of the vaccines. There isn't a giant conspiracy, all the original studies and data are in the open.

Re: Brain imaging before and after Covid-19 in UK Biobank

#123

Post by ohlookabird »

sethammons wrote: post #113
MAGZine wrote: post #74

Earlier quoted context omitted.

You're weighing a real possibility against an unfounded one. P(Complications|Covid) has a calculatable probability. P(Complications|Vaccine) is not, because we don't even know if they exist. And further, we strongly suspect they don't. In other words, I think you're trading one hand for (at best) one in the bush.

Two of my brothers-in-law were hospitalized after receiving the vaccine.

For what?

Re: Brain imaging before and after Covid-19 in UK Biobank

#124

Post by r3trohack3r »

loteck wrote: post #98
r3trohack3r wrote: post #46

Earlier quoted context omitted.

I’m not sure which child to respond to, so responding here. I’m pretty well aligned with this and I’m not sure why it’s getting the downvotes. COVID has never been communicated to me as something serious for my age group. Maybe I’m misinformed, but I’ve never feared getting COVID. I was _terrified_ of needing hospital care _during a hockey stick_. COVID was communicated to me as a hospital killer. I was terrified I’d…

Being a part of a chain of transmission that kills someone, when you could have instead been the person who broke the chain and saved a life?

Are you advocating for full population vaccination of all contagious diseases with mortality rates (that have vaccines) or is there something special about COVID?

Re: Brain imaging before and after Covid-19 in UK Biobank

#125

Post by makomk »

egeozcan wrote: post #8
hallway_monitor wrote: post #6

Earlier quoted context omitted.

Agree completely. That said, ideally I don't want either. Since a lot of people wanted to get vaccinated immediately, I can avoid that and the virus with very high probability. If needed, I'll take v3 or so of the mRNA vaccine.

If many people do what you are doing, some percentage can get the virus and allow it to mutate further, reducing the vaccine efficiency, putting others to risk. Prisoner's dilemma at play. meta edit: I don't like your post becoming completely gray and therefore up-voted you. It's a view that many people hold and it needs to be answered not by screaming "down-vote the selfish!" but rather with good arguments.

Realistically, there's basically no chance of vaccinating enough people fast enough on a global scale to stop the virus mutating further and reducing the vaccine efficacy, probably not even of reducing the odds of it that much, and it's not even clear that the countries with the best vaccine rollouts will manage to stop it spreading at this point. And that's despite vaccination on an unprecedented speed and scale for a disease this new, using technology that didn't even exist a few years ago.

Re: Brain imaging before and after Covid-19 in UK Biobank

#126

Post by takeda »

xwolfi wrote: post #118
throwkeep wrote: post #108

Earlier quoted context omitted.

There are valid concerns and a difficult risk benefit analysis for some cohorts, I think. What are your thoughts on this? Put yourself in her shoes: "I held off on a COVID vaccine because I wanted to wait for data with positive signals for both pregnancy in the short term and long-run fertility. I’m trying to get pregnant, and those are the two things I care about most. Vaccine data is so politicized that it’s actual…

You're right in a way but I think these people are still a tad wrong. It's not that everyone deny there can be side effects, on pregnancy or otherwise. It's that if nobody does the sacrifice, and everybody has his little thing he wants to protect (you want to get pregnant, I want to keep on working, my wife wants to be there for our kid, our parents have diabetes, etc etc) then nobody gets the vaccine. Get it, whatev…

I was also on the fence about vaccine, but what made me take is realization that there isn't only side effects of vaccine, but also side effects of catching covid. Media made us obsessed about deaths, but majority of people survive and among of them small portion get side effects. From what I remember it was about 1 every 10 people that had some kind of issue that lasted after recovering.

Even the blood clots that were found with AZ and J&J are happening with the virus itself at higher rate.

So it's just a simply choosing lesser risk.

Re: Brain imaging before and after Covid-19 in UK Biobank

#127

Post by drno123 »

JohnJamesRambo wrote: post #4

I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?

The difference being, if you choose to get vaccinated, it’s 100% chance that you get mRNA. If you did not get Covid so far, the chances are going down you ever will.

Re: Brain imaging before and after Covid-19 in UK Biobank

#128

Post by sterlind »

ekianjo wrote: post #96
vajrabum wrote: post #55

Earlier quoted context omitted.

What other viral diseases are easily treatable by medication as opposed to vaccination? Are there any?

HIV is effectively treated by tri-therapies.

it took a long time for HAART to be developed though, and a lot of people died during the AZT-only era.

if I had the option of choosing an effective HIV vaccine (god if only!) and HAART, I'd definitely choose the vaccine. HAART is apparently really rough on people.. it ages you.

Re: Brain imaging before and after Covid-19 in UK Biobank

#129

Post by loteck »

r3trohack3r wrote: post #124
loteck wrote: post #98

Earlier quoted context omitted.

Being a part of a chain of transmission that kills someone, when you could have instead been the person who broke the chain and saved a life?

Are you advocating for full population vaccination of all contagious diseases with mortality rates (that have vaccines) or is there something special about COVID?

I'm introducing into your narrative a notion of morality in addition to your narrative (and the siblings narrative) of whether covid vaccination is in your self-interest.

Re: Brain imaging before and after Covid-19 in UK Biobank

#130

Post by Jill_the_Pill »

ganzuul wrote: post #29
causality0 wrote: post #28

Earlier quoted context omitted.

Yeah. I had complete loss of smell and taste, which came back about 90% over the next six weeks. It was fine for a month and then it went wonky. Probably 30% of my "scent spectrum" has now been replaced with the same burnt meat smell/taste. Everything from chocolate to feces to hamburgers now has the same core odor. It really, really sucks.

How old are you? Were you completely healthy before?

My 21-yo daughter was previously completely healthy and fit, and she has now experienced a year of long covid. Already skinny, she lost 16 pounds because food didn't register as food (messed up smell and taste) and she couldn't choke it down. She had a couple of weeks where she could tolerate almost no foods but almonds and miso soup. So much fatigue last summer that she couldn't even sit up for very long. New and persistent depression, sensitivity to noise. Please don't try to minimize this illness by blaming it on people's existing health conditions.
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