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Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

pubmed.ncbi.nlm.nih.gov

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Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#71

Post by rscho »

jcims wrote: post #69
rscho wrote: post #20

This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.

Sometimes 'state-of-the-art' falls short and the moonshot is all you've got.

Certainly. And in that case, you should proceed only if really desired. And realize that doing this is not meant to help you, but to help others who will learn from the experience.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#72

Post by rscho »

drcode wrote: post #35

I have been taking metformin for anti-aging purposes for about 6 months now. I decided to take it mainly because the risks are small, and I wanted to counter the natural bias on these sorts of things, which always leans towards "doing nothing". By taking metformin, it means I have a personal stake in the developoment of anti-aging medicines and have a reason to evaluate any newer options that appear (since there may…

You should be really weary of acidosis. It's dangerous.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#73

Post by jcims »

rscho wrote: post #71
jcims wrote: post #69

Earlier quoted context omitted.

Sometimes 'state-of-the-art' falls short and the moonshot is all you've got.

Certainly. And in that case, you should proceed only if really desired. And realize that doing this is not meant to help you, but to help others who will learn from the experience.

I agree but this proves difficult to pull off practically, at least in the US, because you need to find a provider that will support your choice. Without that you lose access to essentially all standard medicine.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#74

Post by ooyy »

Metabolic syndrome is on the same spectrum of chronic illnesses as type 2 diabetes. It's not surprising that even non-diabetics can benefit from t2d drug metformin considering that only 11% Americans are fully metabolically healthy meaning they meet none of the criteria for metabolic syndrome. But if you are one of these metabolically healthy people, you probably wont benefit from metformin.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#75

Post by agumonkey »

ivankolev wrote: post #29
Filligree wrote: post #25

Earlier quoted context omitted.

> avoid refined sugar and fats that are solid at room temperature. This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.

The dose makes the poison. Everything in excess is detrimental.

except excess, excess in low dose is still detrimental ?

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#76

Post by agumonkey »

MengerSponge wrote: post #19

The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…

after digging in pubmed I realized that just about every thing you can ingest is either good or bad :)

I ended up with small doses of simple natural (don't hit me, I know everything is natural in some way) stuff.

Side note: your social context is also hugely influential. A nice job can amplify every good dimension of ones life without you even trying ..

take care

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#77

Post by mattmcknight »

rscho wrote: post #49
staticassertion wrote: post #38

Earlier quoted context omitted.

What would you consider satisfying evidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/ https://pubmed.ncbi.nlm.nih.gov/31405774/ https://pubmed.ncbi.nlm.nih.gov/31954752/ https://ncbi.nlm.nih.gov/pmc/articles/PMC4287273/

Years and years of widespread clinical practice would be my standard, but I'll make do with multiple large-scale randomized studies AND precise guidelines if absolutely necessary. As for evidence seeking, clinical research happens to be part of my job so I don't really need assistance, thanks.

> Years and years of widespread clinical practice would be my standard

How do you get "years and years of widespread clinical practice" if no one will let people try it?

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#78

Post by rscho »

mattmcknight wrote: post #77
rscho wrote: post #49

Earlier quoted context omitted.

Years and years of widespread clinical practice would be my standard, but I'll make do with multiple large-scale randomized studies AND precise guidelines if absolutely necessary. As for evidence seeking, clinical research happens to be part of my job so I don't really need assistance, thanks.

> Years and years of widespread clinical practice would be my standard How do you get "years and years of widespread clinical practice" if no one will let people try it?

The point of research is to have a controlled experiment. Not a bunch of individuals taking whatever they like on their own.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#79

Post by CodeWriter23 »

nojokes wrote: post #22
CodeWriter23 wrote: post #15

Earlier quoted context omitted.

“alternative” practitioners have been keeping humans healthy for several millennia prior to the existence of the AMA and their so-called “standard of care”.

Those so called alternative practitioners lack scientific rigor, I am afraid of, or more likely just do not know what they are doing. Exceptions exists of course.

Many have more scientific rigor than AMA acolytes. Not all, of course. And then again the AMA and its ilk have plenty of breakdowns of scientific rigor. Let’s see now, vioxx, valsartan, omeprazole, to name a few. And let’s not forget the completely unscientific circus around hydroxychloroquine and those effectively denied treatment on that pack of lies (research surgisphere to get to the truth there)

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#80

Post by quintaindilemma »

rscho wrote: post #20

This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.

But an individual has no choice in his/her actions except the "moonshot". We are individuals, not statistical aggregations. Every choice we make is, in a way, a "moonshot".
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