Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017) • Hacker News Board

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#21

Post by oivey » Sat, Jun 12, 2021, 9:25 PM UTC

CodeWriter23 wrote: post #15

jcims wrote: post #12

Earlier quoted context omitted.

>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…

“alternative” practitioners have been keeping humans healthy for several millennia prior to the existence of the AMA and their so-called “standard of care”.

Sure, but evidence from last several millennia also show they haven’t kept people healthy quite as long.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#22

Post by nojokes » Sat, Jun 12, 2021, 9:26 PM UTC

CodeWriter23 wrote: post #15

jcims wrote: post #12

Earlier quoted context omitted.

>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…

“alternative” practitioners have been keeping humans healthy for several millennia prior to the existence of the AMA and their so-called “standard of care”.

Those so called alternative practitioners lack scientific rigor, I am afraid of, or more likely just do not know what they are doing. Exceptions exists of course.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#23

Post by rscho » Sat, Jun 12, 2021, 9:26 PM UTC

pochamago wrote: post #3

My dad actually switched doctors because his original one refused to prescribe metformin to anyone who wasn't fully diabetic

And rightfully so given the state of the evidence.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#24

Post by healthnut99 » Sat, Jun 12, 2021, 9:26 PM UTC

The only way to get a reliable answer at this point appears to be a large, randomized trial - the TAME trial (https://www.afar.org/tame-trial) was supposed to have started in 2020. Although the official website doesn't say so, I found various articles in the press from late 2019 which said they had raised all the $75 million they needed for it (for example, see https://www.longevity.technology/worlds-first-anti-aging-tri...). After that, it has been radio silence from them - no website updates, no press releases. Although their website says they have clinical sites set up, I haven't been able to find the clinical trials.gov entry for it. I even sent an email to the PI Nil Birzalai (at Montefiore in NYC) a few weeks ago to find out more, but didn't get a response. Does anyone know whether that trial even got off the ground?

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#25

Post by Filligree » Sat, Jun 12, 2021, 9:27 PM UTC

MengerSponge wrote: post #19

The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…

> avoid refined sugar and fats that are solid at room temperature.

This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#26

Post by 238475235243 » Sat, Jun 12, 2021, 9:29 PM UTC

jcims wrote: post #12

238475235243 wrote: post #11

Earlier quoted context omitted.

Yes. And keto, OMAD, etc... They all do the "same thing" in reducing serum glucose and therefore all the downstream bad things that happen. Metformin forms the base plank of novel metabolic cancer regimens too.

>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…

This is easy in the US, check out Care Oncology.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#27

Post by Afforess » Sat, Jun 12, 2021, 9:31 PM UTC

Gwern did some analysis and determined that the ROI for Metformin vs the cost is positive for 45+ and older.

https://www.gwern.net/Longevity#metformin

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#28

Post by ansible » Sat, Jun 12, 2021, 9:31 PM UTC

Filligree wrote: post #25

MengerSponge wrote: post #19

The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…

> avoid refined sugar and fats that are solid at room temperature. This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.

Some oils like rapeseed (canola) aren't that good for you either.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#29

Post by ivankolev » Sat, Jun 12, 2021, 9:32 PM UTC

Filligree wrote: post #25

MengerSponge wrote: post #19

The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…

> avoid refined sugar and fats that are solid at room temperature. This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.

The dose makes the poison. Everything in excess is detrimental.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#30

Post by lambdaba » Sat, Jun 12, 2021, 9:36 PM UTC

MengerSponge wrote: post #19

The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…

Avoiding "solid fats" aka saturated fats is bad advice. The science behind saturated fats being harmful has been debunked and even some government agencies have rescinded the recommendation to avoid them.

On the contrary, it's the liquid fats that are more often harmful, especially linoleic acid (aka omega-6).