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Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

pubmed.ncbi.nlm.nih.gov

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Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#61

Post by staticassertion »

rscho wrote: post #55
staticassertion wrote: post #53

Earlier quoted context omitted.

That seems like a silly standard, but do you.

It's the standard of one particular professional with 15y of clinical practice and research who's seen every kind of manipulation and incompetence in medicine. But yeah, it may be silly. We'll see about that in the coming decades I guess.

I'm not planning to take metformin but it was discovered a century ago and has been in use for half that time. A quick look shows me that it's the 4th most prescribed medication in the US. I find it hard to understand how this would not satisfy "years and years of widespread clinical practice", at least with regards to understanding negative implications.

But as you said, you can do your own research, so I'll leave things where they stand. You just sound more like someone who's annoyed by pop-science more than someone who actually has strong opinions about the article or Metformin.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#62

Post by Nevermark »

clumsysmurf wrote: post #13

Picture seems complicated Our study, performed in C. elegans and human primary fibroblasts shows that there is an age-related decrease in metformin tolerance, which in later life leads to toxicity of all metformin doses tested. This shows possible safety risks of late life administration of metformin to individuals without diabetes," https://medicalxpress.com/news/2020-11-age-decisive-positive...

It would be interesting to know if lower doses were tolerated better while still providing some benefit.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#63

Post by rscho »

staticassertion wrote: post #61
rscho wrote: post #55

Earlier quoted context omitted.

It's the standard of one particular professional with 15y of clinical practice and research who's seen every kind of manipulation and incompetence in medicine. But yeah, it may be silly. We'll see about that in the coming decades I guess.

I'm not planning to take metformin but it was discovered a century ago and has been in use for half that time. A quick look shows me that it's the 4th most prescribed medication in the US. I find it hard to understand how this would not satisfy "years and years of widespread clinical practice", at least with regards to understanding negative implications. But as you said, you can do your own research, so I'll leave t…

I am well aware of the downsides of metformin since someone ends up in my ER (and sometimes dies) because of it most weeks. So you'll excuse me if an off-label and very new potential indication is not an immediate go for me. When we want to open a new indication for a particular drug, evaluation of the risk-benefit ratio for this particular indication has to be performed. There are many factors at play and results are completely unpredictable.

As for the rest no, I'm all for pop-science because it's what stimulates the interest of the masses. The problem in my eyes is more that academic medical studies available to the wider public are akin to a very sharp saw, and people will get cut if they don't know what they're doing.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#64

Post by staticassertion »

rscho wrote: post #63
staticassertion wrote: post #61

Earlier quoted context omitted.

I'm not planning to take metformin but it was discovered a century ago and has been in use for half that time. A quick look shows me that it's the 4th most prescribed medication in the US. I find it hard to understand how this would not satisfy "years and years of widespread clinical practice", at least with regards to understanding negative implications. But as you said, you can do your own research, so I'll leave t…

I am well aware of the downsides of metformin since someone ends up in my ER (and sometimes dies) because of it most weeks. So you'll excuse me if an off-label and very new potential indication is not an immediate go for me. When we want to open a new indication for a particular drug, evaluation of the risk-benefit ratio for this particular indication has to be performed. There are many factors at play and results ar…

Yeah I'd recommend you open up with information like that in the future, just right off the bat. It's a lot more interesting and at least somewhat useful.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#65

Post by the__alchemist »

rscho wrote: post #49
staticassertion wrote: post #38

Earlier quoted context omitted.

What would you consider satisfying evidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/ https://pubmed.ncbi.nlm.nih.gov/31405774/ https://pubmed.ncbi.nlm.nih.gov/31954752/ https://ncbi.nlm.nih.gov/pmc/articles/PMC4287273/

Years and years of widespread clinical practice would be my standard, but I'll make do with multiple large-scale randomized studies AND precise guidelines if absolutely necessary. As for evidence seeking, clinical research happens to be part of my job so I don't really need assistance, thanks.

This is an appeal to authority.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#66

Post by redis_mlc »

drcode wrote: post #35

I have been taking metformin for anti-aging purposes for about 6 months now. I decided to take it mainly because the risks are small, and I wanted to counter the natural bias on these sorts of things, which always leans towards "doing nothing". By taking metformin, it means I have a personal stake in the developoment of anti-aging medicines and have a reason to evaluate any newer options that appear (since there may…

> By taking metformin, it means I have a personal stake in the development of anti-aging medicines

You sound like an insane person. Talk to somebody you respect and have them explain how you're not going to live forever, and it's not your job to be a voluntary lab rat.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#68

Post by hungryforcodes »

drcode wrote: post #35

I have been taking metformin for anti-aging purposes for about 6 months now. I decided to take it mainly because the risks are small, and I wanted to counter the natural bias on these sorts of things, which always leans towards "doing nothing". By taking metformin, it means I have a personal stake in the developoment of anti-aging medicines and have a reason to evaluate any newer options that appear (since there may…

Isn't it supposed to prevent you from absorbing vitamin B12, which is pretty serious.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#69

Post by jcims »

rscho wrote: post #20

This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.

Sometimes 'state-of-the-art' falls short and the moonshot is all you've got.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#70

Post by rscho »

the__alchemist wrote: post #65
rscho wrote: post #49

Earlier quoted context omitted.

Years and years of widespread clinical practice would be my standard, but I'll make do with multiple large-scale randomized studies AND precise guidelines if absolutely necessary. As for evidence seeking, clinical research happens to be part of my job so I don't really need assistance, thanks.

This is an appeal to authority.

Yes. To say that I don't need assistance. It spares people the effort of scouring Pubmed for nothing.
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