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Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

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Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#51

Post by rscho »

jcims wrote: post #12
238475235243 wrote: post #11

Earlier quoted context omitted.

Yes. And keto, OMAD, etc... They all do the "same thing" in reducing serum glucose and therefore all the downstream bad things that happen. Metformin forms the base plank of novel metabolic cancer regimens too.

>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…

And choloroquine! Let's not forget chloroquine. It can beat anything.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#52

Post by shaicoleman »

void_mint wrote: post #45
shaicoleman wrote: post #39

Earlier quoted context omitted.

I think the best talk of the health dangers of seed oils is in the following video: Dr. Chris Knobbe - 'Diseases of Civilization: Are Seed Oil Excesses the Unifying Mechanism?' [1] If you're short on time, you can skip directly to the trials data section [2] 1. https://youtu.be/7kGnfXXIKZM 2. https://youtu.be/7kGnfXXIKZM?t=2020

> in rats So we're deriving that an entire class of foods aren't "good for you", because of a specific outcome in a study conducted on rats? edit Also, the effect produced on the rats was weight gain. Is all weight gain bad? Oils aren't "good for you" because "weight gain"? So, if a person's goal was to gain weight, would oils be "good for them"? And if yes, isn't this just way too broad a statement ("oils aren't goo…

Indeed, not all animal trials are valid in humans, and your skepticism is warranted.

In the rest of the video he discusses how it affects human health, along with the data to support that assertion.

It's seed/vegetable and hydrogenated oils that are bad for you and are correlated with obesity, heart disease, diabetes and cancer.

Coconut oil, olive oil and butter are fine.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#53

Post by staticassertion »

rscho wrote: post #49
staticassertion wrote: post #38

Earlier quoted context omitted.

What would you consider satisfying evidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/ https://pubmed.ncbi.nlm.nih.gov/31405774/ https://pubmed.ncbi.nlm.nih.gov/31954752/ https://ncbi.nlm.nih.gov/pmc/articles/PMC4287273/

Years and years of widespread clinical practice would be my standard, but I'll make do with multiple large-scale randomized studies AND precise guidelines if absolutely necessary. As for evidence seeking, clinical research happens to be part of my job so I don't really need assistance, thanks.

That seems like a silly standard, but do you.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#54

Post by jcims »

238475235243 wrote: post #26
jcims wrote: post #12

Earlier quoted context omitted.

>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…

This is easy in the US, check out Care Oncology.

That’s who we used, they made it very simple. Our oncologist was not pleased though.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#55

Post by rscho »

staticassertion wrote: post #53
rscho wrote: post #49

Earlier quoted context omitted.

Years and years of widespread clinical practice would be my standard, but I'll make do with multiple large-scale randomized studies AND precise guidelines if absolutely necessary. As for evidence seeking, clinical research happens to be part of my job so I don't really need assistance, thanks.

That seems like a silly standard, but do you.

It's the standard of one particular professional with 15y of clinical practice and research who's seen every kind of manipulation and incompetence in medicine. But yeah, it may be silly. We'll see about that in the coming decades I guess.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#56

Post by basch »

Filligree wrote: post #25
MengerSponge wrote: post #19

The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…

> avoid refined sugar and fats that are solid at room temperature. This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.

>refined sugar

I wouldn't personally consider rolled oats, rolled barley, or rolled rye to be refined sugars, nor are they quite in the white rice, potato, corn, flour starch category, despite flattening a "grass seed/fruit" being a type of "processing."

Furthermore, oversimplifying food advice tends to leave out conversation of how food breaks down. The main ways are time, grinding, heat, fermentation. Fermentation gets a bit of an asterisk at the end of hard rules lists. They may say no dairy but then exempt fermented dairy. Lactofermentation of oats will be less starchy than uncooked oats.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#57

Post by gremloni »

rscho wrote: post #20

This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.

No matter what, the underlying reality, is that there are certain chemical you can take in the right amount per person to give you the best health possible. We might not be there for a while but studies help us in that direction.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#58

Post by rscho »

gremloni wrote: post #57
rscho wrote: post #20

This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.

No matter what, the underlying reality, is that there are certain chemical you can take in the right amount per person to give you the best health possible. We might not be there for a while but studies help us in that direction.

Yes, I agree. But not all studies. There is a substantial proportion of studies that are just statistical noise, and a smaller but still substantial part that are outright fraud.

However, individual experiments are not studies in the academic sense. Especially if they are not formally reported so that the experience is not lost in time.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#59

Post by hellbannedguy »

CodeWriter23 wrote: post #15
jcims wrote: post #12

Earlier quoted context omitted.

>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…

“alternative” practitioners have been keeping humans healthy for several millennia prior to the existence of the AMA and their so-called “standard of care”.

The magic of placebo. Chiropractic school dropout, with the bonus of having a ex girlfriend who was a Herbal Doctor. A Naturopath? I forget.

What really sealed the deal was this one professor. Attractive lady whom spoke like she was addressing the United Nations. I still remember the time she told me to show the class my Coccyx. I was relieve I had good underware on.

Back to the most rediculious statement from the red lipstick mouth of a PhD. (I comment on her appearance because she was cute. So--please don't take it any other way. I know there are people waiting to pounce.)

She stated,

"We have over 15 upper cervical techniques, and they All work equally well." Studies, and Placebo Effect are conviently never talked about at that school."

That said, I feel most modern medicine is not much better.

Placebo rules in every healing art.

The kid in front of me, at Chiro school, was the spitting image of health. I was actually jealous. He was getting weekly adjustments. He was getting something called a Rotary Adjustment.

He was biking with his wife, and father in-law on a sunny Saturday. He stopped peddling, and fell over. Died of a massive stroke, at 25.

While I'm here. Sharon Stone was a big Chiro fanatic. Out of the blue she developed bilateral aneurisms, or tears?, in her neck. A world renowned vascular surgeon happened to be giving a talk at UCSF. The hospital asked him to perform the delicate surgery. It was obviously successful.

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#60

Post by rscho »

jcims wrote: post #54
238475235243 wrote: post #26

Earlier quoted context omitted.

This is easy in the US, check out Care Oncology.

That’s who we used, they made it very simple. Our oncologist was not pleased though.

I'm so happy and relieved that I don't have to practice in the US anymore.
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