31–40 of 86 posts
It certainly is a powerful pharmaceutical. It can impact aquatic life that live in treated waste water effluent. "Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish." https://www.sciencedirect.com/science/article/pii/S004565351...
human life > fish life
Earlier quoted context omitted.
> avoid refined sugar and fats that are solid at room temperature. This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.
Some oils like rapeseed (canola) aren't that good for you either.
Edit: apparently coconut oil is supposed to be solid at room temp. I should get an air conditioner
It certainly is a powerful pharmaceutical. It can impact aquatic life that live in treated waste water effluent. "Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish." https://www.sciencedirect.com/science/article/pii/S004565351...
Earlier quoted context omitted.
> avoid refined sugar and fats that are solid at room temperature. This leaves, what, protein and starch? And cooking oil, I suppose, but all forms of meat contain solid fats.
Some oils like rapeseed (canola) aren't that good for you either.
Can you explain, in what capacity oils aren't "good for you" ?
By taking metformin, it means I have a personal stake in the developoment of anti-aging medicines and have a reason to evaluate any newer options that appear (since there may be a reason to switch metformin to another treatment) I feel like taking metformin makes me less biased when it comes to evaluating treatments in the field, even if I think the efficacy of metformin is still an open question.
In terms of side effects, I have noted mild gastric upset (I actually wonder if this is part of its mechanism of action, making you less hungry in this way) but little impact on exercise (I take it even on days that I exercise, and I have a fairly heavy exercise routine)
The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…
Why?
This whole comment section is totally delusional regarding the reliability of medical statistics and preliminary data in life science. It's funny (and sad) to see people easily disparaging "state-of-the-art treatments" be so prone to experiment on themselves with moonshot claims.
Eggs are healthy, eggs are unhealthy, eggs are really unhealthy, eggs are healthy, eggs are really healthy.
I had trained medical professionals tell me twenty years ago that I was going to ruin my kidneys with my low-carb dieting. Twenty years later, I'm still keeping the weight off and medical science has started to catch up to what I knew just by experimenting on myself with moonshot claims.
The biggest problem with medical science (just look at how COVID issues were butchered by politics and celebrity), is that they refuse to just say, "We don't really know." Because all too often, they have no clue. But they are trained to come up with answers and sound confident about it.
My dad actually switched doctors because his original one refused to prescribe metformin to anyone who wasn't fully diabetic
And rightfully so given the state of the evidence.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/ https://pubmed.ncbi.nlm.nih.gov/31405774/ https://pubmed.ncbi.nlm.nih.gov/31954752/ https://ncbi.nlm.nih.gov/pmc/articles/PMC4287273/
Earlier quoted context omitted.
Some oils like rapeseed (canola) aren't that good for you either.
These articles always bring up a lot of comments that use the phrase "good for you" or "healthy", but in my experience most of the time a person saying "___ is good for you", they pretty much never quantify how or why. Can you explain, in what capacity oils aren't "good for you" ?
Dr. Chris Knobbe - 'Diseases of Civilization: Are Seed Oil Excesses the Unifying Mechanism?' [1]
If you're short on time, you can skip directly to the trials data section [2]
The only miracle drugs that I know of are sleep, water, and exercise. Even those have dose-related toxicities! https://peterattiamd.com/metformin-and-exercise/ If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.…
Avoiding "solid fats" aka saturated fats is bad advice. The science behind saturated fats being harmful has been debunked and even some government agencies have rescinded the recommendation to avoid them. On the contrary, it's the liquid fats that are more often harmful, especially linoleic acid (aka omega-6).