11–20 of 86 posts
Could this be replicating what fasting and caloric restriction do?
Metformin forms the base plank of novel metabolic cancer regimens too.
Could this be replicating what fasting and caloric restriction do?
Yes. And keto, OMAD, etc... They all do the "same thing" in reducing serum glucose and therefore all the downstream bad things that happen. Metformin forms the base plank of novel metabolic cancer regimens too.
For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'.
There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and even some clinical trials to help fight cancer through a number of mechanisms. Independently they are not likely sufficient to beat cancer but may slow its roll through the body of the patient.
Our study, performed in C. elegans and human primary fibroblasts shows that there is an age-related decrease in metformin tolerance, which in later life leads to toxicity of all metformin doses tested. This shows possible safety risks of late life administration of metformin to individuals without diabetes,"
https://medicalxpress.com/news/2020-11-age-decisive-positive...
Comparison of metformin and berberine based on Cochrane meta-analysis: https://www.youtube.com/watch?v=OPsMMfSQKQ0
Earlier quoted context omitted.
Yes. And keto, OMAD, etc... They all do the "same thing" in reducing serum glucose and therefore all the downstream bad things that happen. Metformin forms the base plank of novel metabolic cancer regimens too.
>Metformin forms the base plank of novel metabolic cancer regimens too. For which you'll likely have to lie to or find an alternative oncologist who's willing to tolerate adjuvant therapies that aren't 'standard of care'. There are organizations that are developing protocols that include metformin along with statins, anthelmintics and even some antibiotics that are showing promise across a variety of research and eve…
Could this be replicating what fasting and caloric restriction do?
Yes, there's evidence for that. However the jury is still out on whether metformin is a net benefit for people with healthy insulin sensitivity. It appears there are negative effects: Derek Lowe talks about the negative effects of metformin on healthy people: https://blogs.sciencemag.org/pipeline/archives/2019/06/24/me ... Peter Attia talks about the same, and some interesting other considerations: https://peterattia…
Earlier quoted context omitted.
Yes, there's evidence for that. However the jury is still out on whether metformin is a net benefit for people with healthy insulin sensitivity. It appears there are negative effects: Derek Lowe talks about the negative effects of metformin on healthy people: https://blogs.sciencemag.org/pipeline/archives/2019/06/24/me ... Peter Attia talks about the same, and some interesting other considerations: https://peterattia…
Metformin likely blunts the impact of high intensity exercise. But for the 65% of people living sedentary or low activity lives, it’s a straight win. Even for those who are consistent with physical fitness, the downsides can likely be avoided by waiting a few hours after the morning exercise session to dose.
It certainly is a powerful pharmaceutical. It can impact aquatic life that live in treated waste water effluent. "Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish." https://www.sciencedirect.com/science/article/pii/S004565351...
human life > fish life
https://peterattiamd.com/metformin-and-exercise/
If you're healthy enough to exercise, that's probably more effective. Apparently (I haven't tested myself, and I don't know how thorough the literature is) metformin lowers your lactic threshold, which reduces the total amount of work you can do in that state.
Do cardio, sleep enough, avoid refined sugar and fats that are solid at room temperature. More than that... godspeed