Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#1

Post by optimalsolver » Sat, Jun 12, 2021, 7:22 PM UTC

Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)
pubmed.ncbi.nlm.nih.gov

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#2

Post by api » Sat, Jun 12, 2021, 8:23 PM UTC

Could this be replicating what fasting and caloric restriction do?

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#3

Post by pochamago » Sat, Jun 12, 2021, 8:30 PM UTC

My dad actually switched doctors because his original one refused to prescribe metformin to anyone who wasn't fully diabetic

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#4

Post by [deleted] » Sat, Jun 12, 2021, 8:35 PM UTC

[deleted]

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#5

Post by nate_meurer » Sat, Jun 12, 2021, 8:36 PM UTC

api wrote: post #2

Could this be replicating what fasting and caloric restriction do?

Yes, there's evidence for that. However the jury is still out on whether metformin is a net benefit for people with healthy insulin sensitivity. It appears there are negative effects:

Derek Lowe talks about the negative effects of metformin on healthy people:

https://blogs.sciencemag.org/pipeline/archives/2019/06/24/me...

Peter Attia talks about the same, and some interesting other considerations:

https://peterattiamd.com/191013/

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#6

Post by [deleted] » Sat, Jun 12, 2021, 8:49 PM UTC

pochamago wrote: post #3

My dad actually switched doctors because his original one refused to prescribe metformin to anyone who wasn't fully diabetic

[deleted]

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#7

Post by macinjosh » Sat, Jun 12, 2021, 8:59 PM UTC

It certainly is a powerful pharmaceutical. It can impact aquatic life that live in treated waste water effluent.

"Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish."

https://www.sciencedirect.com/science/article/pii/S004565351...

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#8

Post by birriel » Sat, Jun 12, 2021, 9:05 PM UTC

Comparison of metformin and berberine based on Cochrane meta-analysis:

https://www.youtube.com/watch?v=OPsMMfSQKQ0

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#9

Post by wetpaws » Sat, Jun 12, 2021, 9:06 PM UTC

macinjosh wrote: post #7

It certainly is a powerful pharmaceutical. It can impact aquatic life that live in treated waste water effluent. "Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish." https://www.sciencedirect.com/science/article/pii/S004565351...

human life > fish life

Re: Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)

#10

Post by dcolkitt » Sat, Jun 12, 2021, 9:06 PM UTC

nate_meurer wrote: post #5

api wrote: post #2

Could this be replicating what fasting and caloric restriction do?

Yes, there's evidence for that. However the jury is still out on whether metformin is a net benefit for people with healthy insulin sensitivity. It appears there are negative effects: Derek Lowe talks about the negative effects of metformin on healthy people: https://blogs.sciencemag.org/pipeline/archives/2019/06/24/me ... Peter Attia talks about the same, and some interesting other considerations: https://peterattia…

Metformin likely blunts the impact of high intensity exercise. But for the 65% of people living sedentary or low activity lives, it’s a straight win. Even for those who are consistent with physical fitness, the downsides can likely be avoided by waiting a few hours after the morning exercise session to dose.