They pissed off the left by being sociopathic big businesses that treated people poorly. They pissed off the right by exerting perceived control over public discourse. They've pissed off government in general by swinging around their power when called out on these things. It wasn't a question of if the feds would screw them it was a question of when.
They pissed off the left by moving in on their turf. Big tech is a direct threat to universities, journalism, media, and entertainment industries. It's not a threat, and even a benefit to transportation, oil/gas/mining, and agriculture, which are more republican industries.