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Drug users use a lot of drugs

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Re: Drug users use a lot of drugs

#131

Post by FeepingCreature »

yerwhat01010 wrote: post #113
newbie789 wrote: post #39

Earlier quoted context omitted.

Meth does not make you crave any type of food. If that were the case Desoxyn would not be FDA approved for weight loss. “Meth mouth” is caused by the fact that it dries your mouth out, you grind your teeth a LOT, and is often observed in people that have used drugs long/hard enough to find themselves no longer taking care of their health in general, let alone oral hygiene. This often is coupled with financial ruin an…

Wait, are you saying that meth is popular among Silicon Valley coders and rich house wives? This is news to me.

Adderall. I can't find a Wiki cite for the specific use among coders, but it's stereotypically widespread as a nootropic.

Re: Drug users use a lot of drugs

#132

Post by Nursie »

cwkoss wrote: post #72
heisenbit wrote: post #54

Drug processing in the body can sometimes be surprising. I learned recently about first pass effect which means the drug heads first to the liver and only what passes through is available to the body. So if one ups the dose and the liver processing is saturated a double dose can deliver much more punch than two single ones. The body has many non-linear features and extrapolating several orders of magnitude is often n…

Yep, this is why "boofing" (intrarectal) dosing has found rising popularity in the 'research chemical' scene over the past couple decades. The liver's effects on drugs is really fascinating. Grapefruit has a chemical that can inactive liver enzymes, so some drug addicts regularly drink grapefruit juice to 'get more bang for their buck'. Plain old black pepper (in large doses) inactivates a different enzyme IIRC. Ther…

I used to take a more active interest in that scene, some years ago. I had dabbled with well known substances over the years but had always been fascinated by the reports of novel or unusual substances on erowid, and resources like Tihkal and Pihkal.

So to me the sudden easy availability of (say) variations on the MDMA molecule to skirt past the UK misuse of drugs act (at the time) that resulted in the aminopropylbenzofuran family were an amazing thing, a little because of the legal status but mainly because it was appealing in itself. I wouldn't know where to find MDA, or MDEA or such things, but suddenly APB, MAPB, EAPB and other variants were there. I was able to try some of the novel tryptamines that came out of that without having the in-depth illicit-chemist hookups usually needed to source these things, even a novel lysergamide or two.

You're right to be concerned about the novel benzos, and also the novel cannabinoids, IMHO.

Re: Drug users use a lot of drugs

#134

Post by bambataa »

droopyEyelids wrote: post #28
oogetyboogety wrote: post #24

Earlier quoted context omitted.

I mean, not literally 50. Like 3 times the potency, maybe 5 or 6 times the potency of whatever your state average black market, grey market, or illegally grown crop is. It's important to clear up the FUD here because it has led to some backwards progress for legalization in states like Colorado recently.

Let's say you use a 0.5 g dab which has a THC content of 70% (most dabs are either 1-gram or 0.5 g). The wax has 0.35 g (350 mg of THC), but you could lose up to one-third of it when vaporizing. If this happens, you’ll end up with roughly 235 mg of THC per hit (if you can finish the whole dab in one hit). Someone without a THC tolerance will be completely satisfied with a 5mg dose, total. Thats 47 doses out of the 23…

Dude, one gram of wax does for a year. I can’t imagine how awful doing half in one go would be.

It’s true though that concentrated sources like this make it technically possible to ingest amounts that weren’t feasible before, I suppose.

Re: Drug users use a lot of drugs

#135

Post by astrange »

heisenbit wrote: post #54

Drug processing in the body can sometimes be surprising. I learned recently about first pass effect which means the drug heads first to the liver and only what passes through is available to the body. So if one ups the dose and the liver processing is saturated a double dose can deliver much more punch than two single ones. The body has many non-linear features and extrapolating several orders of magnitude is often n…

> So if one ups the dose and the liver processing is saturated a double dose can deliver much more punch than two single ones. The body has many non-linear features and extrapolating several orders of magnitude is often not possible.

Since we're talking about amphetamine here, this is actually the way Vyvanse works (it's bound to L-lysine and the liver splits it apart) and those nonlinearities are the reason it has such a longer effect life than Dexedrine/Adderall IR.

As an unfortunate side effect, you have to watch the pH of the meal you take it with, eg taking it with orange juice completely inactivates it.

Re: Drug users use a lot of drugs

#136

Post by stordoff »

cwkoss wrote: post #119
stordoff wrote: post #106

Earlier quoted context omitted.

> i have a morbid fascination with the 'frontier non-medical drug use' communities I share this interest. I've very little interest in using drugs recreationally myself, but find reading about it oddly fascinating, particularly the novel agents. Taking a chemical when you only have the vaguest idea of what it _may_ do crosses a line I would never want to, but I sympathise with the feeling of wanting to know the effec…

Well, to share some of my favorite morbid findings: --- Melanotan is a peptide that increases skin pigmentation. Some people have tested it to the extreme, and the pictures are some combination of funny, terrifying and "at what point is this racially offensive blackface?". Also supposedly causes erections similarly to sildenafil . https://www.reddit.com/r/WTF/comments/3gxjem/before_and_afte... --- The etizolam not wo…

> often with many spelling errors that led many commenters to be pretty sure that it was working just fine

"i'm not high, i can do perfecly things functionally" pretty much sums that up - https://www.reddit.com/r/researchchemicals/comments/67g4a7/e... ("my memory is semi crystal clear" is also a great claim)

Re: Drug users use a lot of drugs

#137

Post by astrange »

cwkoss wrote: post #72
heisenbit wrote: post #54

Drug processing in the body can sometimes be surprising. I learned recently about first pass effect which means the drug heads first to the liver and only what passes through is available to the body. So if one ups the dose and the liver processing is saturated a double dose can deliver much more punch than two single ones. The body has many non-linear features and extrapolating several orders of magnitude is often n…

Yep, this is why "boofing" (intrarectal) dosing has found rising popularity in the 'research chemical' scene over the past couple decades. The liver's effects on drugs is really fascinating. Grapefruit has a chemical that can inactive liver enzymes, so some drug addicts regularly drink grapefruit juice to 'get more bang for their buck'. Plain old black pepper (in large doses) inactivates a different enzyme IIRC. Ther…

> Plain old black pepper (in large doses) inactivates a different enzyme IIRC.

It's actually surprisingly effective as long as you don't mind just eating peppercorns. It definitely reduces the high from THC in edibles (and it's the only thing I know of that does besides CBD), and it promotes the health effects of turmeric.

Re: Drug users use a lot of drugs

#138

Post by astrange »

treeman79 wrote: post #40
bawolff wrote: post #9

Earlier quoted context omitted.

Adderall is also a stimulant(?) The authors suggestion is it would cause the same effect if taken in the same dosage.

I was on Adderall 10mg a day. Worked as advertised. ADHD under control. Chronic fatigue fixed. Every portion of my body felt like it was being burned from the inside. I had to start tramadol to counter act the pain. It also upped cranial pressure. Causing a lot of secondary problems. This was made much worse as dosage went up. I had to stop it before downward spiral completely destroyed me. Vyvanse was a mild version…

I've never heard of this symptom! Maybe you were allergic? It does sound like SJS, in which case you should definitely quit it, but I thought that could only happen with modafinil.

Re: Drug users use a lot of drugs

#139

Post by astrange »

FeepingCreature wrote: post #131
yerwhat01010 wrote: post #113

Earlier quoted context omitted.

Wait, are you saying that meth is popular among Silicon Valley coders and rich house wives? This is news to me.

Adderall. I can't find a Wiki cite for the specific use among coders, but it's stereotypically widespread as a nootropic.

Adderall is not meth. It does promote jaw clenching some, but it's not nearly as bad for you (as the article says, mostly because prescribed doses are smaller) and in fact is neuroprotective.

I don't think housewives would enjoy abusing it, unless they're studying for the GRE.

Re: Drug users use a lot of drugs

#140

Post by Broken_Hippo »

mxxc wrote: post #133

hooray another article that focuses on the heavy tail of severe addiction and generalises it to the general public who uses drugs. humanity really needed this!

You know, I thought it was going that way when I started reading it - but by the end, I really didn't feel like you do.

But realistically, it compared dosages of drugs in heavy users compared to regular use at medical doses and the side effects of them. It never stated these were normal users, just stating the things that happen with a lot of use. I was surprised.

Sure, it could have went on to say that occasional recreational use probably won't hurt you, but that's difficult when it could be seen as promoting drugs and a lot of places have pretty draconian drug laws.

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