Drug users use a lot of drugs • Hacker News Board

Re: Drug users use a lot of drugs

#111

Post by jlarocco » Thu, Jun 10, 2021, 7:13 AM UTC

newbie789 wrote: post #32

Former meth addict here. > The average crystal meth addict uses about 500 mg a day. And they snort it, which probably produces about double the peak plasma level as taking it orally. So they're getting the equivalent of 1000 mg oral amphetamine daily... 500mg sounds about right, but from my experience the most common route of administration (in the western United States at least) is smoking, not snorting. Because so…

> I like this article overall but I get irritated when I read stuff about drug users that is clearly written by somebody who hasn’t done a lot of drugs.

To be fair, though, medical doctors with personal experience using meth are probably a very small group, and it's unlikely they're in a big hurry to write an article talking about their experience. But who knows...

Re: Drug users use a lot of drugs

#112

Post by collyw » Thu, Jun 10, 2021, 7:29 AM UTC

newbie789 wrote: post #32

Former meth addict here. > The average crystal meth addict uses about 500 mg a day. And they snort it, which probably produces about double the peak plasma level as taking it orally. So they're getting the equivalent of 1000 mg oral amphetamine daily... 500mg sounds about right, but from my experience the most common route of administration (in the western United States at least) is smoking, not snorting. Because so…

Having been an addict, what's your views on legislation?

Re: Drug users use a lot of drugs

#113

Post by yerwhat01010 » Thu, Jun 10, 2021, 7:30 AM UTC

newbie789 wrote: post #39

rogerclark wrote: post #2

"The most important reason meth makes your teeth fall out and ruins your life but Adderall just makes you study a little harder is that the meth users are taking 50x higher doses" The reason meth addicts have bad teeth isn't because of the dosage of the drug. It's because stimulants make you want to eat candy and drink sugar water, because meth addicts lose track of oral hygiene in favor of doing meth or something el…

Meth does not make you crave any type of food. If that were the case Desoxyn would not be FDA approved for weight loss. “Meth mouth” is caused by the fact that it dries your mouth out, you grind your teeth a LOT, and is often observed in people that have used drugs long/hard enough to find themselves no longer taking care of their health in general, let alone oral hygiene. This often is coupled with financial ruin an…

Wait, are you saying that meth is popular among Silicon Valley coders and rich house wives? This is news to me.

Re: Drug users use a lot of drugs

#114

Post by neolog » Thu, Jun 10, 2021, 7:32 AM UTC

newbie789 wrote: post #32

Former meth addict here. > The average crystal meth addict uses about 500 mg a day. And they snort it, which probably produces about double the peak plasma level as taking it orally. So they're getting the equivalent of 1000 mg oral amphetamine daily... 500mg sounds about right, but from my experience the most common route of administration (in the western United States at least) is smoking, not snorting. Because so…

How long does a high last?

How many uses during a normal day? e.g. 125 mg 4x daily or all at once or something else?

Does it keep you from sleeping?

Re: Drug users use a lot of drugs

#115

Post by refurb » Thu, Jun 10, 2021, 7:33 AM UTC

rogerclark wrote: post #2

"The most important reason meth makes your teeth fall out and ruins your life but Adderall just makes you study a little harder is that the meth users are taking 50x higher doses" The reason meth addicts have bad teeth isn't because of the dosage of the drug. It's because stimulants make you want to eat candy and drink sugar water, because meth addicts lose track of oral hygiene in favor of doing meth or something el…

It's purely due to a dry mouth. People that get radiation therapy for head and neck cancers get severe dry mouth as well (salivary glands affected) and severe tooth decay is common unless you use artificial saliva.

Re: Drug users use a lot of drugs

#116

Post by Smithalicious » Thu, Jun 10, 2021, 7:35 AM UTC

cwkoss wrote: post #66

I think another major factor that this article didn't point out is drug purity - and what those specific impurities are. Particularly with drugs like meth, which can be manufactured clandestinely by people who don't understand chemistry well, there are a lot of intermediates or potential reaction byproducts which are orders of magnitude more cardiotoxic or otherwise more harmful than pure methamphetamine. And that's…

AFAIK almost all street ketamine is just diverted medical supply. Might be cut with something, but other than that it is pharmaceutical grade.

Re: Drug users use a lot of drugs

#117

Post by m-ee » Thu, Jun 10, 2021, 7:48 AM UTC

jlarocco wrote: post #111

newbie789 wrote: post #32

Former meth addict here. > The average crystal meth addict uses about 500 mg a day. And they snort it, which probably produces about double the peak plasma level as taking it orally. So they're getting the equivalent of 1000 mg oral amphetamine daily... 500mg sounds about right, but from my experience the most common route of administration (in the western United States at least) is smoking, not snorting. Because so…

> I like this article overall but I get irritated when I read stuff about drug users that is clearly written by somebody who hasn’t done a lot of drugs. To be fair, though, medical doctors with personal experience using meth are probably a very small group, and it's unlikely they're in a big hurry to write an article talking about their experience. But who knows...

Unless this is a regional thing I wonder where the doctor even got that idea, I wasn't even aware people snort meth until now. Meanwhile I walked past two people lighting up after leaving a job interview in soma last week. Any doctor who's worked in the ER or psych ward in SF would be familiar with how its used, meth induced psychosis is very common around here.

Re: Drug users use a lot of drugs

#118

Post by collyw » Thu, Jun 10, 2021, 7:58 AM UTC

trestenhortz wrote: post #21

I watched a documentary about ketamine use by party people. It profiled a young guy who had destroyed his bladder and needed to use a pump and hole in his belly to urinate. Really disturbing.

Google some youtube videos about kokodil, its a drug used in Russia, cheap and very nasty, basically makes skin fall off of people

Re: Drug users use a lot of drugs

#119

Post by cwkoss » Thu, Jun 10, 2021, 8:01 AM UTC

stordoff wrote: post #106

cwkoss wrote: post #72

Earlier quoted context omitted.

Yep, this is why "boofing" (intrarectal) dosing has found rising popularity in the 'research chemical' scene over the past couple decades. The liver's effects on drugs is really fascinating. Grapefruit has a chemical that can inactive liver enzymes, so some drug addicts regularly drink grapefruit juice to 'get more bang for their buck'. Plain old black pepper (in large doses) inactivates a different enzyme IIRC. Ther…

> i have a morbid fascination with the 'frontier non-medical drug use' communities I share this interest. I've very little interest in using drugs recreationally myself, but find reading about it oddly fascinating, particularly the novel agents. Taking a chemical when you only have the vaguest idea of what it _may_ do crosses a line I would never want to, but I sympathise with the feeling of wanting to know the effec…

Well, to share some of my favorite morbid findings:

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Melanotan is a peptide that increases skin pigmentation. Some people have tested it to the extreme, and the pictures are some combination of funny, terrifying and "at what point is this racially offensive blackface?". Also supposedly causes erections similarly to sildenafil .

https://www.reddit.com/r/WTF/comments/3gxjem/before_and_afte...

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The etizolam not wokrign meme https://www.google.com/search?q=etizolam+not+working+reddit

Unfortunately can't find the original post, but when this benzo was easy to buy, there were frequent threads for a while from different users who were complaining that they weren't feeling the effects... often with many spelling errors that led many commenters to be pretty sure that it was working just fine and the posters are just not aware of how intoxicated they are. Became a bit of a meme.

Kind of like the 'roofie circle' Gob story arc from arrested development, it seems very common that people will take some, forget they took it once it kicks in, take more, forget, and so on. When you can order 1000 doses for the price of a paycheck, it leads to very bad outcomes. Often these stories end up with people blacking out for weeks or months at a time, destroying personal relationships, property and their careers, and only regain awareness after weeks in jail or a hospital. Pretty scary stuff.

Also, several stories from people buying time locked safes so they don't redose, blacking out, and finding their timelocked safe destroyed and empty.

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Cops arrest guy with RCs, etizolam and a mescaline derivative. Cop "accidentally" gets some on his lips (probably thought it was heroin and had a dip?) and gets sent to the infirmary tripping. Suspect is released when the substances turn out to be legal (but not for long - possibly in part because of this incident)

https://www.reddit.com/r/researchchemicals/comments/fpery3/c...

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The stories about "bath salts" pyrovalerones like aPVP and MDPV are quite insane. Extremely potent and addictive. These are like the fentanyls of the stimulant class and propel users into psychosis with relative ease. Like, compressing the effects of a 2-week meth binge into a single weekend, with all of the negatives that come along with that. I believe the report of the florida man who ate someone's face off was under the influence of one of these.

https://erowid.org/experiences/exp.php?ID=101129

http://www.orangejuiceblog.com/2011/05/man-high-on-bath-salt...

https://en.wikipedia.org/wiki/Miami_cannibal_attack

Re: Drug users use a lot of drugs

#120

Post by anon9001 » Thu, Jun 10, 2021, 8:03 AM UTC

newbie789 wrote: post #32

Former meth addict here. > The average crystal meth addict uses about 500 mg a day. And they snort it, which probably produces about double the peak plasma level as taking it orally. So they're getting the equivalent of 1000 mg oral amphetamine daily... 500mg sounds about right, but from my experience the most common route of administration (in the western United States at least) is smoking, not snorting. Because so…

Thanks for sharing.

A lot of people on this board have experience with prescription stimulants. How would you say the experience of "doing meth" differs from taking amphetamine orally? Was a typical experience for you "smoke meth, study or write code all night"?

I like prescription stimulants, but it's hard for me to imagine anyone wanting to take overdose-levels of stimulants for fun, so I'm probably missing something. If I take too much (~40mg), I feel pretty terrible, physically and mentally. I can't imagine how 500mg/day could produce any desirable effects.

If the supply chain for meth wasn't so poor, I'd probably try it once to see what all the hype is about.