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Trials begin on lozenge that rebuilds tooth enamel

dental.washington.edu

321–330 of 364 posts

Re: Trials begin on lozenge that rebuilds tooth enamel

#321

Earlier quoted context omitted.

We usually do masseter and temporalis muscles.

Any idea if it works for tinnitus?

Try and see whether you can relax your jaw (if you do it right your tongue would hang lower than usual and it may feel like saliva is produced at a faster rate), and see if tinnitus retreats after a while. If it does, I would speculate that the shots would then also work, though it may be helpful to find a psychosomatic approach first. (I'm not a doctor but familiar with such cases).

Re: Trials begin on lozenge that rebuilds tooth enamel

#322
post #31

> In addition, the researchers are investigating a gel or solution with the engineered peptide to treat hypersensitive teeth. This problem results from weakness in the enamel that makes the underlying dentin and nerves more vulnerable to heat or cold. Most common products currently on the market can put a layer of organic material on the tooth and numb nerve endings with potassium nitrate, but the relief is only temp…

Have you looked into botox shots at all? When I tell you my life changed completely from a 15 minute botox appointment with an oral surgeon I am not exaggerating in the least. I’d had no idea what it felt like to live without bruxism - not only were my teeth better but my neck stopped aching, my back muscles stopped spasming, and I stopped getting migraines entirely. I had gotten debilitating migraines once every mon…

Sounds like TMJ issue.

I suffer horrific migraines. One day after someone mentioned TMJ. I started massage various points around jaw. Found an incredibly painful spot. Worked on it over 3 days until it stopped hurting. Migraines stopped. Several months later they started again. That same spot was bad again. Same results.

Botox is an another way to deal with it.

Re: Trials begin on lozenge that rebuilds tooth enamel

#323
post #31

> In addition, the researchers are investigating a gel or solution with the engineered peptide to treat hypersensitive teeth. This problem results from weakness in the enamel that makes the underlying dentin and nerves more vulnerable to heat or cold. Most common products currently on the market can put a layer of organic material on the tooth and numb nerve endings with potassium nitrate, but the relief is only temp…

Get yourself checked for Periodontitis [1]. (Assuming the bruxism is self-diagnosed based on your lack of dental practice visits.)

This is a common condition whereby bacteria get between the gum and teeth. It starts with sticky "plaque" from food and saliva, which hardens into tartar, which can get below the gumline. Bacteria grows in the tartar, which in time causes inflammation. At this point the damage isn't permanent and will be fixed by a dental clean. The inflammation causes swollen gums, which may be sore when brushed, and in the longer term the bone around your teeth recedes away from the inflammation. The receding bone leaves gaps around the teeth, which exposes their roots, making them sensitive, and the gaps exacerbate the condition by providing the bacteria a difficult to clean safe harbour. At this point the damage is becoming permanent, but treatment can prevent it from becoming worse. Left untreated over a period of years, the bone recedes so much that your teeth become loose, eventually falling out. End game is false teeth or equivalent. It's possible for the swollen gums to cover up the other symptoms by the swelling gums temporarily filling the gaps left by receding bone. The disease progresses over many years, so it's easy to ignore until there are permanent effects, but early treatment (a dental clean) will make it go away.

In the years before permanent damage the only symptom can be an occasional gum soreness which goes away after a few days and doesn't seem worth worrying about.

As far as I can make out, brushing delays Periodontitis by slowing tartar buildup, but over a period of many years it's not enough and one has to eventually go to a dentist to get the tartar scraped off, so Periodontitis causing bacteria have less places to live. Basically no dental visits over a period of many years with a typical diet = Periodontitis with permanent effects.

[1] https://www.healthline.com/health/periodontitis

Re: Trials begin on lozenge that rebuilds tooth enamel

#324

Earlier quoted context omitted.

This isn't so much a prevention of tooth decay as it is a contribution to the hydroxyapatite crystal structure in a non-regenerable part of your tooth.

Could you please explain? What is a non-regenerable part of a tooth and what is a regenerable part of it? Why repairing its crystal structure is not a prevention of its decay?

The outer hard enamel layer of your teeth is acellular and cannot regenerate after it forms. Its been a while since I worked in this field (my PhD) but the inner dentin has some ability to regenerate due to the adjacent cells in the pulp. I'm not really sure I understand what the previous comment is saying about the crystal structure. All of the tooth (enamel and dentin) and bone mineral related carbonate "hydroxyl" apatite is crystalline with some additional amorphous material in between.

Re: Trials begin on lozenge that rebuilds tooth enamel

#325
post #54

I've always wondered how come there wasn't more effort put into something like this. It's a huge business opportunity. Everyone hates going to the dentist.

Teeth have remarkable intricate structure, simple depositing some disordered mineral using a bio-mimetic peptide isn't the same as regenerating your enamel. Remaking your actual tooth material is very difficult (currently no method is really known). Once the enamel is formed the cells die off and you are stuck with what you've got. Hopefully restorative options like this may be modestly successful but I'm skeptical. I worked in this area during my PhD.

Re: Trials begin on lozenge that rebuilds tooth enamel

#326
post #310

Earlier quoted context omitted.

> French press "muddiness" is not invariant but rather a function of filter size and type. It's the equivalent of steak doneness, use the appropriate equipment for the result you want. I don’t think this contradicts anything I said. > Espresso is fundamentally different than pour-over. Pour-over is only using atmospheric pressure and espresso is about only not using atmospheric pressure. To clarify, I meant that the…

Thoughts on aeropress vs espresso machine quality?

I don’t actually have any thoughts on aeropress! I’ve never tried it. Despite the differences I notice, my preference of brew process is mostly about convenience (other than not cooking it on a burner), I’m happy with a French press at home and either drip or espresso at a cafe, whichever gets me out the door quickest. So it’s rare I try a new one unless there’s a social reason.

I know lots of people love aeropress and if you’re curious I’d say give it a try and see if you like it :)

Re: Trials begin on lozenge that rebuilds tooth enamel

#327
post #269

Earlier quoted context omitted.

Yeah it’s not the roast, it’s the brewing/extraction method. Drip/pour over extract more caffeine than espresso, presumably from longer exposure to more surface area.

Longer exposure but less surface area (coarser grind).

Yep, good correction!

Re: Trials begin on lozenge that rebuilds tooth enamel

#328
post #257

Earlier quoted context omitted.

I just found they have a gum solution as well - GengiGel [0]. [0]: https://www.gengigel.de/

Nope, completely different thing: Xylitol, Gum Base, Calcium Phosphate, Acacia Gum, Glycerin, Aroma, CI 77891, Lecitin of Soya, Glycyrrhiza Glabra Extract, Cera Carnauba.

This is a different product - as I clarified, it claiming benefits for gums' health due to its hyaluronate contents.

Re: Trials begin on lozenge that rebuilds tooth enamel

#329

Earlier quoted context omitted.

Contrasting points... You can close your mouth., but can’t stop someone from looking at your head. You can surgically replace all your teeth with perfect replicas and no one will be able to tell otherwise except in how perfect they are. The cost for this isn’t low, but nor is it unobtainable. I bet $10k in Eastern Europe gets you nice teeth for the rest of your life. There is just no great option for hair. Even with…

For the vast majority of people who experience hair loss, it’s... normal and expected, maybe somewhat romantically limiting. Poor dental health can be poor health overall. Traveling to Eastern Europe to spend $10k for something I actually need is not an option for me. Yeah I can close my mouth. And suffer. And let it keep rotting, crossing my fingers that related health impacts don’t get to me before I can pay a car’…

Go for cleanings even if you don't fix the cavities right away.

Re: Trials begin on lozenge that rebuilds tooth enamel

#330
post #165

> The idea for the lozenge design originated with Deniz Yucesoy, a graduate student in the UW’s Genetically Engineered Materials Science and Engineering Center who received a $100,000 Amazon Catalyst grant This grad-student/researcher just handed over a multi-million dollar business to Amazon in exchange for $100k towards the research. Why on Earth would anyone sign over 100% ownership of their idea, just to be able…

As long as it's disclosed beforehand, I don't see any problem with that. It's not like Amazon coerced the student into the contract: if they had a better funding opportunity they'd obviously have gone for it. This is the best deal they could get and Amazon was also obviously taking a risk: for every successful project, there are hundreds that don't get anywhere.
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