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Trials begin on lozenge that rebuilds tooth enamel

dental.washington.edu

161–170 of 364 posts

Re: Trials begin on lozenge that rebuilds tooth enamel

#162

Earlier quoted context omitted.

Have you looked into botox shots at all? When I tell you my life changed completely from a 15 minute botox appointment with an oral surgeon I am not exaggerating in the least. I’d had no idea what it felt like to live without bruxism - not only were my teeth better but my neck stopped aching, my back muscles stopped spasming, and I stopped getting migraines entirely. I had gotten debilitating migraines once every mon…

Can you describe more specifically where the Botox was injected? What muscle(s) did it paralyze?

I don’t know the muscles but maybe someone here can chime in with the specific names from this very unscientific description: on each side of my head kind of near my temples and on each side of my jaw near the corner(?) bone. (Really regretting never having taken an anatomy class...) If you put your finger on your earlobe and pull it maybe an inch forward I would say it was about there. My doctor kindly used some sort of very cold topical numbing spray before the injections which meant I couldn’t feel much. So in addition to my description being very unscientific it could also be slightly inaccurate.

I think my doctor was somewhat unique (at least at the time) for doing the temple injections to treat TMJ and I think the temple is one of the injection locations used now when someone gets Botox for migraines. I know there were additional possible injection sites he used for more severe cases or where there wasn’t complete relief but I can’t recall where they were because I didn’t end up needing them.

Re: Trials begin on lozenge that rebuilds tooth enamel

#163
post #150

Earlier quoted context omitted.

If you switched from drip, the caffeine is actually lower! My guess is you’re just more satisfied with the coffee you’re enjoying.

True, the darker the roast (ie roasted longer), generally the less caffeine it has in it. Espresso has some of the least since it is one of the darkest roasts.

That is an urban myth unfortunately, darker coffee does not have less caffeine because caffeine is heat stable at typical roasting temperatures. (20 to 240C). Here’s a more thorough explanation of it: https://www.kickinghorsecoffee.com/caffeine-myths-dark-vs-li...

The effect probably came to be known because darker roaster coffee is less dense. So if you are measuring your coffee by volume (i.e. eyeballing it) and not mass, for the same volume the darker the coffee the less caffeine it has. But per gram of coffee, it’s pretty much the same.

Re: Trials begin on lozenge that rebuilds tooth enamel

#164
post #38

Earlier quoted context omitted.

Have you tried a toothpaste with Stannous Fluoride? Potassium nitrate never helped me any, but stannous fluoride has helped with my tooth sensitivity.

Doesn't pretty much all toothpaste have that? Unless its kid's toothpaste or something specifically for people who are avoiding flouride.

Stannous as in tin (SnF2). Other fluoride toothpastes often use sodium fluoride or sodium monofluorophosphate. Stannous fluoride is slightly more likely to stain your teeth.

Re: Trials begin on lozenge that rebuilds tooth enamel

#165
> The idea for the lozenge design originated with Deniz Yucesoy, a graduate student in the UW’s Genetically Engineered Materials Science and Engineering Center who received a $100,000 Amazon Catalyst grant

This grad-student/researcher just handed over a multi-million dollar business to Amazon in exchange for $100k towards the research. Why on Earth would anyone sign over 100% ownership of their idea, just to be able to test their idea? I guess he thought it would look good on his resume as begs a company for a job after graduation?

Who owns the IP if I join Amazon Catalyst?[1]

Amazon Catalyst is a place to see your idea come to fruition without the risk of starting a company on your own. As such, the IP that is developed in Amazon Catalyst is property of Amazon.[1]

[1] https://catalyst.amazon.com/

Re: Trials begin on lozenge that rebuilds tooth enamel

#166
post #92
post #31

> In addition, the researchers are investigating a gel or solution with the engineered peptide to treat hypersensitive teeth. This problem results from weakness in the enamel that makes the underlying dentin and nerves more vulnerable to heat or cold. Most common products currently on the market can put a layer of organic material on the tooth and numb nerve endings with potassium nitrate, but the relief is only temp…

Although I haven't personally tried it, I have friends outside of the US that rave about Sensodyne Repair & Protect original with the "Powered by NovaMin" badging. NovaMin is composed of special ceramic particles that coat the teeth with a compound that reacts with the saliva to form a durable physical barrier. The problem is that the stuff with NovaMin is not typically available in the US. I just searched Amazon and…

That Sensodyne paste struck some memories; I recall having seen it at a local shop, possibly even trying it, although at a much lower price, and a quick check on a local price list site confirms it.

https://translate.google.com/translate?sl=auto&tl=en&u=https...

All prices under €4, but of course shipping rates are for local delivery and I have no idea if the sellers can ship abroad, most of them might not even speak a word of English, however here they are; making quite a big order would defeat the costs for shipping to the US, which usually are high.

Re: Trials begin on lozenge that rebuilds tooth enamel

#167
post #31

> In addition, the researchers are investigating a gel or solution with the engineered peptide to treat hypersensitive teeth. This problem results from weakness in the enamel that makes the underlying dentin and nerves more vulnerable to heat or cold. Most common products currently on the market can put a layer of organic material on the tooth and numb nerve endings with potassium nitrate, but the relief is only temp…

I have a similar problem but sleeping with a night guard helps, and also Gel Kam twice daily is much more effective than the sensitive tooth toothpaste.

Re: Trials begin on lozenge that rebuilds tooth enamel

#168
post #122

If we chew on enough of these lozenges, will our teeth merge into one, curved megatooth?

And why haven't we evolved to have that yet anyway? It's surely better, nowhere for food to get stuck? (Assuming it can still be molar/canine/incisor like in different places on that plane.)

> And why haven't we evolved to have that yet anyway? It's surely better, nowhere for food to get, stuck? (Assuming it can still be molar/canine/incisor like in different places on that plane.)

Well, in software terms, you're describing a monolithic architecture. A single cavity would destroy the whole thing. You'd probably have to replace the choppers more frequently as your skull grows into adulthood, or we would have to be born with larger jaws that don't need to grow as much as we mature.

There is also the matter of how evolvable the platform would be. As a species, we're in the process of losing our wisdom teeth, and I suspect that would be harder to do if the skull/jaw/gum/tooth platform was... more tightly coupled, less modular.

I myself never had any wisdom teeth, and kept a couple of my milk teeth into my 40s before one had to be replaced with a crown, and the other just fell out when the root dissolved. Human dentition has a lot of variability.

Still, birds did it (as have other species over the Earth's long evolutionary history), so it isn't an insoluble challenge, but it would be a rather more radical change than just fusing teeth together.

Re: Trials begin on lozenge that rebuilds tooth enamel

#169
post #165

> The idea for the lozenge design originated with Deniz Yucesoy, a graduate student in the UW’s Genetically Engineered Materials Science and Engineering Center who received a $100,000 Amazon Catalyst grant This grad-student/researcher just handed over a multi-million dollar business to Amazon in exchange for $100k towards the research. Why on Earth would anyone sign over 100% ownership of their idea, just to be able…

what if there’s more to an idea than how much money you personally can extract from it?

Re: Trials begin on lozenge that rebuilds tooth enamel

#170
post #165

> The idea for the lozenge design originated with Deniz Yucesoy, a graduate student in the UW’s Genetically Engineered Materials Science and Engineering Center who received a $100,000 Amazon Catalyst grant This grad-student/researcher just handed over a multi-million dollar business to Amazon in exchange for $100k towards the research. Why on Earth would anyone sign over 100% ownership of their idea, just to be able…

That doesnt appear to be a grant at all then! Are government or nonprofit grants ever attached to IP ownership terms?
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