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Trials begin on lozenge that rebuilds tooth enamel

dental.washington.edu

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Re: Trials begin on lozenge that rebuilds tooth enamel

#191

Post by cossatot »

genericone wrote: post #170
jb775 wrote: post #165

> The idea for the lozenge design originated with Deniz Yucesoy, a graduate student in the UW’s Genetically Engineered Materials Science and Engineering Center who received a $100,000 Amazon Catalyst grant This grad-student/researcher just handed over a multi-million dollar business to Amazon in exchange for $100k towards the research. Why on Earth would anyone sign over 100% ownership of their idea, just to be able…

That doesnt appear to be a grant at all then! Are government or nonprofit grants ever attached to IP ownership terms?

Usually the IP goes to the employer (i.e. the university) rather than the individual researcher.

Re: Trials begin on lozenge that rebuilds tooth enamel

#192

Post by SoylentYellow »

etxm wrote: post #171
xivzgrev wrote: post #161

This is cool but I really want something that can regrow my gums. I’ve had some recession and I have sensitivity to cold liquids. The dentists say the only option is surgery

Same. I’ve had two grafts in the same area (cadaver and auto) and neither of them held. What drives me wild is I floss twice a day, brush three times a day with the daintiest grip you’ve ever seen. Every time I go to the dentist, recession. Meanwhile my spouse brushes once a day, maybe flosses occasionally and has never had recession or a cavity.

I'm about to get a donor graft soon. Why didn't your's work out?

Re: Trials begin on lozenge that rebuilds tooth enamel

#193

Post by kart23 »

vineyardmike wrote: post #46
windexh8er wrote: post #35

Earlier quoted context omitted.

Mostly no. Keep in mind people are not born with perfect teeth by default. My SO is a DDS and has been practicing for about 15 years now. The bulk of her workday is definitely not fillings. Remember people break teeth, grind teeth, teeth die (trauma, health, etc), people want cosmetic work and the list goes on and on. She loves this type of thing to let people help themselves - but it often doesn't work. There's prod…

What is this product you mentioned that reverses the start of cavities? Any google of it is filled with cheap SEO for me.

prescription toothpaste.

Most common is prevident 5000

Re: Trials begin on lozenge that rebuilds tooth enamel

#194

Post by cableshaft »

EMM_386 wrote: post #120
monoideism wrote: post #59

Earlier quoted context omitted.

> (it doesn’t hurt!) It doesn't hurt for you . Some people, including myself, have had root canals that have almost caused worse pain than when I was in the ICU.

> It doesn't hurt for you. Some people, including myself, have had root canals that have almost caused worse pain than when I was in the ICU. I am just going to have the tooth pulled. They argued either try to save it, or just have it taken out. I dread dentists, and especially endodontists/root canals. There are enough reports of severe pain and I want no part of it, unless I go the expensive sleep dentistry route.

I've had two root canals done with local anesthetic and no real problems. I was real nervous for the first one and went to a specialist and they used a lot of local anesthetic that I couldn't feel anything but a little pressure.

But the second time I just had my doctor do it with his anesthetic, and it wasn't much worse than a filling for me. A little unpleasant but not unbearable.

On the negative side, either that or some other dental work I had done close to the same time must have damaged a nerve and now I haven't been able to really taste anything in the front half of my tongue the past three years (still can on the back of my tongue, at least, thankfully).

Re: Trials begin on lozenge that rebuilds tooth enamel

#195

Post by eyelidlessness »

SV_BubbleTime wrote: post #149
eyelidlessness wrote: post #135

Earlier quoted context omitted.

It’s really astonishing how I know, intuitively, this is true but how weird people’s priorities are. Being honest: 1. I started balding at a relatively normal age (first signs late 20s). At first I welcomed it, then I got a little self conscious (and wished for greys instead, those are finally coming into my beard and I couldn’t be happier). 2. I’ve had dental health issues since childhood. My family couldn’t afford…

Contrasting points... You can close your mouth., but can’t stop someone from looking at your head. You can surgically replace all your teeth with perfect replicas and no one will be able to tell otherwise except in how perfect they are. The cost for this isn’t low, but nor is it unobtainable. I bet $10k in Eastern Europe gets you nice teeth for the rest of your life. There is just no great option for hair. Even with…

For the vast majority of people who experience hair loss, it’s... normal and expected, maybe somewhat romantically limiting. Poor dental health can be poor health overall. Traveling to Eastern Europe to spend $10k for something I actually need is not an option for me.

Yeah I can close my mouth. And suffer. And let it keep rotting, crossing my fingers that related health impacts don’t get to me before I can pay a car’s value to get health care. Or people can look at my bald head and... nothing meaningful happened.

I appreciate your kindness in expressing this contrarian view, but it’s not helpful.

Re: Trials begin on lozenge that rebuilds tooth enamel

#196

Post by hackily »

chihuahua wrote: post #111
jcrben wrote: post #81

Earlier quoted context omitted.

I put baking soda in my drinking water, as mentioned at https://news.ycombinator.com/item?id=27329115 - typically 1 teaspoon per liter

Doesn't the stomach acid instantly neutralize that?

I sure hope your stomach acid isn't finding it's way into your mouth! The point is to raise the pH in the mouth so your teeth, since acidity causes calcium to leach out of your teeth

Re: Trials begin on lozenge that rebuilds tooth enamel

#197

Post by sabellito »

totalZero wrote: post #175
jb775 wrote: post #165

> The idea for the lozenge design originated with Deniz Yucesoy, a graduate student in the UW’s Genetically Engineered Materials Science and Engineering Center who received a $100,000 Amazon Catalyst grant This grad-student/researcher just handed over a multi-million dollar business to Amazon in exchange for $100k towards the research. Why on Earth would anyone sign over 100% ownership of their idea, just to be able…

If you're an academic researcher, you probably don't care as much about the ownership of IP when compared to a potential to see your work get used and to build a reputation as a competent person in your field. Also, the work wouldn't necessarily exist without the funding.

Well, we are talking about a possibly multi-million dollar product here. If Amazon were a bit less predatory perhaps keep 99% of the IP?

Re: Trials begin on lozenge that rebuilds tooth enamel

#198

Post by Godel_unicode »

eyelidlessness wrote: post #181
jcims wrote: post #142

Earlier quoted context omitted.

Definitely enjoy it more. Brewed coffee started tasting like stewed coffee or something, the americanos just have a 'cleaner' hit...i don't know. The weird thing is I find pourover to be more like espresso than brewed in that way, so it's probably just all in my head lol. Anyway, point is I only drink one cup a day now and have become a closet coffee snob.

Pourover is more like espresso too. Almost the same mechanism, but espresso also uses pressure. And even though snobs will disagree, french press will be closer in flavor but “muddier”. Drip is pretty much the worst because it starts reheating your already perfectly good coffee before it’s even done. Welcome to the snobbery! I went from “I refuse to order a coffee with more than two words” to super opinionated and pi…

This is all almost totally incorrect.

French press "muddiness" is not invariant but rather a function of filter size and type. It's the equivalent of steak doneness, use the appropriate equipment for the result you want.

Espresso is fundamentally different than pour-over. Pour-over is only using atmospheric pressure and espresso is about only not using atmospheric pressure. Pour-over is closer to drip than espresso.

Drip coffee is actually just pour-over coffee made with a machine, and using a warming burner is not required.

How good your coffee is depends not at all on the method used, and anyone telling you it does is just encoding their preference. Goodness of coffee is a combination of acidity, sweetness, bitterness, ratio of water to non-water compounds, time spent, and enjoyment of the experimentation. This combination is achieved by varying grind size, water temperature, bean roast, contact time, and experimenter time.

Re: Trials begin on lozenge that rebuilds tooth enamel

#199

Post by nikodunk »

elliekelly wrote: post #80
Hamuko wrote: post #31

> In addition, the researchers are investigating a gel or solution with the engineered peptide to treat hypersensitive teeth. This problem results from weakness in the enamel that makes the underlying dentin and nerves more vulnerable to heat or cold. Most common products currently on the market can put a layer of organic material on the tooth and numb nerve endings with potassium nitrate, but the relief is only temp…

Have you looked into botox shots at all? When I tell you my life changed completely from a 15 minute botox appointment with an oral surgeon I am not exaggerating in the least. I’d had no idea what it felt like to live without bruxism - not only were my teeth better but my neck stopped aching, my back muscles stopped spasming, and I stopped getting migraines entirely. I had gotten debilitating migraines once every mon…

Thank you so much for posting this! I’ve ground my teeth badly my whole life, it’s starting to get to the bad parts of my teeth and gums receding etc etc despite retainers, and I’ll definitely look into this!

Yours,

Guy at the end of his enamel

Re: Trials begin on lozenge that rebuilds tooth enamel

#200

Post by Godel_unicode »

eyelidlessness wrote: post #195
SV_BubbleTime wrote: post #149

Earlier quoted context omitted.

Contrasting points... You can close your mouth., but can’t stop someone from looking at your head. You can surgically replace all your teeth with perfect replicas and no one will be able to tell otherwise except in how perfect they are. The cost for this isn’t low, but nor is it unobtainable. I bet $10k in Eastern Europe gets you nice teeth for the rest of your life. There is just no great option for hair. Even with…

For the vast majority of people who experience hair loss, it’s... normal and expected, maybe somewhat romantically limiting. Poor dental health can be poor health overall. Traveling to Eastern Europe to spend $10k for something I actually need is not an option for me. Yeah I can close my mouth. And suffer. And let it keep rotting, crossing my fingers that related health impacts don’t get to me before I can pay a car’…

> normal and expected

That sounds like wishful thinking, if it were true there wouldn't be a giant market in covering up hair loss.

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