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Current RNA vaccines protect against worrying coronavirus variants

nature.com

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Re: Current RNA vaccines protect against worrying coronavirus variants

#51

Post by blacksoil »

sigmaprimus wrote: post #38
vmception wrote: post #33

I literally saw the opposite headline about Pzifer versus a strain in India today The actual article said "modest antibody evading capabilities“ I hate that the internet has become this way

I agree, unfortunately there have been so many half truths and misleading articles both online and on legacy media that I find myself not knowing what or who to trust anymore. I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation. Five years ago I would not be having these doubts but it seems like everyone has alterior motives. I wish the so…

I'm not sure why you're being downvoted...

Re: Current RNA vaccines protect against worrying coronavirus variants

#52

Post by flobosg »

deanclatworthy wrote: post #46
M4v3R wrote: post #44

Earlier quoted context omitted.

Since it’s based basically on the same mRNA technology (and has the same reported efficacy) I would assume it works as well as the Pfizer one. No hard data to back this up, though.

This is a false assumption as they have different mRNA instructions. As you point out, wait until there is data and treat the vaccines independently.

> This is a false assumption as they have different mRNA instructions

Depending on what you mean by “mRNA instructions” that might not be the case. Both vaccine mRNAs encode exactly the same variant of the spike protein.

Re: Current RNA vaccines protect against worrying coronavirus variants

#53

Post by fastball »

deanclatworthy wrote: post #46
M4v3R wrote: post #44

Earlier quoted context omitted.

Since it’s based basically on the same mRNA technology (and has the same reported efficacy) I would assume it works as well as the Pfizer one. No hard data to back this up, though.

This is a false assumption as they have different mRNA instructions. As you point out, wait until there is data and treat the vaccines independently.

The overall mRNA is different due to different signal peptides, untranslated regions (UTR), etc. But the mRNA sequence that encodes the spike protein is identical, and presumably that is what would give resistance to variants.

Re: Current RNA vaccines protect against worrying coronavirus variants

#54

Post by rantwasp »

flobosg wrote: post #52
deanclatworthy wrote: post #46

Earlier quoted context omitted.

This is a false assumption as they have different mRNA instructions. As you point out, wait until there is data and treat the vaccines independently.

> This is a false assumption as they have different mRNA instructions Depending on what you mean by “mRNA instructions” that might not be the case. Both vaccine mRNAs encode exactly the same variant of the spike protein.

yes, but no. while it’s technically the same protein, the way it was optimized differs (not by much but it’s different). the vaccine itself has the instructions to produce something that resembles the spike protein (to which your immune system goes in overdrive and generates antibodies)

Re: Current RNA vaccines protect against worrying coronavirus variants

#55

Post by reedjosh »

vmception wrote: post #42
sigmaprimus wrote: post #38

Earlier quoted context omitted.

I agree, unfortunately there have been so many half truths and misleading articles both online and on legacy media that I find myself not knowing what or who to trust anymore. I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation. Five years ago I would not be having these doubts but it seems like everyone has alterior motives. I wish the so…

If you already have an appointment the only debate should be whether you will need an additional third booster shot in the future if the strain in India breaks out and is different enough. The key thing you should notice about the COVID vaccine detractors is their inability to distinguish between vaccines and the wildly different technology between the different vaccines, alongside their inability acknowledge the geo…

> acknowledge the geopolitical hurdles

Each of those vaccines come from a UN/WHO member country.

Geo politically power is wielded by globalist financial elites. These elites generally believe the world is overpopulated. Bill himself is well known for his this belief. Bill as an example runs a charitable foundation that only ever seems to make money.

These conspiracies are not constituted of a flat earth and aliens. They are of human hierarchies, corruption, and psychopaths.

Re: Current RNA vaccines protect against worrying coronavirus variants

#56

Post by sigmaprimus »

vmception wrote: post #42
sigmaprimus wrote: post #38

Earlier quoted context omitted.

I agree, unfortunately there have been so many half truths and misleading articles both online and on legacy media that I find myself not knowing what or who to trust anymore. I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation. Five years ago I would not be having these doubts but it seems like everyone has alterior motives. I wish the so…

If you already have an appointment the only debate should be whether you will need an additional third booster shot in the future if the strain in India breaks out and is different enough. The key thing you should notice about the COVID vaccine detractors is their inability to distinguish between vaccines and the wildly different technology between the different vaccines, alongside their inability acknowledge the geo…

I live in Canada so it is age based. I'm guessing it will be either Pfizer or Moderna both of which are mRNA which from my understanding is a form of gene therapy.

My main concern at the moment is: Just as the virus can mutate during it's replicatative phase and produce variants why can't the spiked protien during it's production or the cells producing it mutate also?

If these production cells can mutate or the spiked protiens themselves mutate is it reasonable to assume an autoimmune diseases may result as the cells or protiens accumulate in my organs, limphnodes, fat cells or other areas?

This is an honest concern that I am hoping can be resolved, rather than be dismissed or attacked.

Re: Current RNA vaccines protect against worrying coronavirus variants

#57

Post by loxias »

sigmaprimus wrote: post #38
vmception wrote: post #33

I literally saw the opposite headline about Pzifer versus a strain in India today The actual article said "modest antibody evading capabilities“ I hate that the internet has become this way

I agree, unfortunately there have been so many half truths and misleading articles both online and on legacy media that I find myself not knowing what or who to trust anymore. I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation. Five years ago I would not be having these doubts but it seems like everyone has alterior motives. I wish the so…

> I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancellation.

Cancellation??!??! WTF? Why? You have a free, safe, live-saving vaccine being offered to you! Why would you not take it??

Putting aside the fact that not being vaccinated is a horrible selfish act that hastens the evolution of a more virulent strain and more death, don't you want to relax a bit after this past year?

Re: Current RNA vaccines protect against worrying coronavirus variants

#58

Post by tialaramex »

petertodd wrote: post #19
timr wrote: post #9

Earlier quoted context omitted.

> [1] A glaring counterexample to your hypothesis is Brazil (Manuas) where prior infections (as high as 60%) didn't stop the P1 variant from ripping through. The prior infection estimates for Manaus were simply wrong . They were based on a paper that "adjusted" the observed seroprevalence rates upward by a factor of ~3x. The parsimonious conclusion is that these corrections were too aggressive and ended up over-estim…

Conversely, we can make the same argument in the opposite direction with the example of Seychelles, which in spite of the highest vaccination level in the world, is still seeing significant growth in cases: https://www.bbc.com/news/world-africa-56992121 Apparently they're using 40% Astra Zeneca, 60% Sinopharm; hopefully the issue is simply the latter being ineffective. But as all the success stories with vaccination…

I don't see how anywhere could get to count as a "success story with vaccination" under your criteria while also not having "significant numbers of deaths with covid" and so I don't think you end up with a meaningful observation.

New Zealand had zero community cases without vaccination, during 2021 its vaccination programme has only covered some front line workers and very high risk people, and it still has zero community cases. Is that "success"? Is it "not success" ? How would you tell?

Whereas in my own country about two thirds of adults have had at least one jab, but still people are dying every single day from COVID-19, just much fewer than an the height of the pandemic here. Is that a success? Not a success?

One of the reasons New Zealand was so slow? With zero cases they had no reason to do Emergency Authorization. So they didn't. The Pfizer vaccine they picked got the full (albeit accelerated) approval process that any other medicine would get. This behaviour would be crazy in a country like the US with thousands dying, but it made sense in a country where most citizens have negligible risk day-to-day.

Re: Current RNA vaccines protect against worrying coronavirus variants

#59

Post by ramraj07 »

vmception wrote: post #33

I literally saw the opposite headline about Pzifer versus a strain in India today The actual article said "modest antibody evading capabilities“ I hate that the internet has become this way

Can you actually link to a source?

Re: Current RNA vaccines protect against worrying coronavirus variants

#60

Post by dnautics »

cycrutchfield wrote: post #43
sigmaprimus wrote: post #38

Earlier quoted context omitted.

I agree, unfortunately there have been so many half truths and misleading articles both online and on legacy media that I find myself not knowing what or who to trust anymore. I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation. Five years ago I would not be having these doubts but it seems like everyone has alterior motives. I wish the so…

>I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation. Sorry, what is the downside to getting the vaccine in your mind?

I advocate getting vaccinated (I am myself) but if people don't want to put foreign substances into their bodies, we should respect their choices, especially since the long-term risk profile is unknown (we are pretty sure it's safe, but who can know?)
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