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Current RNA vaccines protect against worrying coronavirus variants

nature.com

31–40 of 324 posts

Re: Current RNA vaccines protect against worrying coronavirus variants

#31
post #17

Until it doesn't? I am far from an expert (so please correct me if I'm wrong), but isn't this like saying "the dam can stop any amount of water" ?

No, a dam fails all at once. What has been seen in mutant strains (if anything different) is somewhat reduced protection.

Re: Current RNA vaccines protect against worrying coronavirus variants

#32
post #26

Earlier quoted context omitted.

We aren’t “declaring victory”, premature or otherwise, over anything; the results of research that are important in understanding the current, evolving landscape are being published.

I was referring to the headline, which very much has a "mission accomplished" spin to it: >Pfizer Covid vaccine protects against worrying coronavirus variants It reads as: "Don't be worried, Pfizer has the variant problem solved."

> I was referring to the headline, which very much has a "mission accomplished" spin to it

That’s really reading a lot into what is a simple, concise, factual headline. There are a set of currently-worrying variants (about which there had been much public concern about the effectiveness of current vaccines), and the Pfizer vaccine is effective against them.

That headline is very much not a “Mission Accomplished” banner.

Re: Current RNA vaccines protect against worrying coronavirus variants

#34
post #16
post #2

So, then I would assume this means people with antibodies from the initial wave of infections are also protected

mRNA vaccines produce antibodies targeting just the spike protein( S protein). There are other proteins on the virus like the M protein. Antibodies produced during an infection may target other parts of the virus so you can’t compare the two.

Isn't it the spike protein that is usually different between these variants? In that case antibodies that target a different part should even be more effective.

Re: Current RNA vaccines protect against worrying coronavirus variants

#35
post #18

I hate headlines that try to tell me how I should feel about something. It seems like it would be equally informative without the “worrying”.

"worrying" is an identifiern of the variants.

If it protects against the 2 least significant variants, that's less interesting of an article.

Unless it protects against all variants the headline would likely be inaccurate without the "worrying" qualifier.

I could agree with a criticism that "worrying" should be replaced with a better identifier of the specific variants being discussed, but I don't have a replacement proposal. And dropping the word "worrying" seems like it might be factually wrong (it also might not be, I don't know)

Re: Current RNA vaccines protect against worrying coronavirus variants

#36
post #10
post #3

Earlier quoted context omitted.

Interestingly, the mRNA vaccines produce superior immunity compared to getting infected, due mainly to the two dose regimen. For similarly long-lasting natural immunity you'd probably need to get infected with covid twice.

There's also the benefit that with the mRNA vaccines (and the adenovirus vaccines as well), your body is developing antibodies specifically for the spike protein, which is highly conserved. Your body's immune response to actual covid may, just by chance, focus on a less strongly conserved target.

I was under the impression that it's the other way around; spike protein is not conserved between variants [1]:

https://theconversation.com/new-coronavirus-variant-what-is-...

Re: Current RNA vaccines protect against worrying coronavirus variants

#37
post #26

Earlier quoted context omitted.

I was referring to the headline, which very much has a "mission accomplished" spin to it: >Pfizer Covid vaccine protects against worrying coronavirus variants It reads as: "Don't be worried, Pfizer has the variant problem solved."

> I was referring to the headline, which very much has a "mission accomplished" spin to it That’s really reading a lot into what is a simple, concise, factual headline. There are a set of currently-worrying variants (about which there had been much public concern about the effectiveness of current vaccines), and the Pfizer vaccine is effective against them. That headline is very much not a “Mission Accomplished” bann…

Emphasis on "currently" which is my entire point and is conveniently left out of the headline. It's an irresponsible headline for something so serious.

Re: Current RNA vaccines protect against worrying coronavirus variants

#38

I literally saw the opposite headline about Pzifer versus a strain in India today The actual article said "modest antibody evading capabilities“ I hate that the internet has become this way

I agree, unfortunately there have been so many half truths and misleading articles both online and on legacy media that I find myself not knowing what or who to trust anymore.

I have an appointment to get my first jab in 43 hours from now and I am bouncing back and forth between getting it and cancelation.

Five years ago I would not be having these doubts but it seems like everyone has alterior motives.

I wish the social media giants would just stop all the censorship and allow the discussions to take place. I appreciate that they are trying to stop disinformation but I just can't think of one time in the past that the ones stifling free speach have ever been on the right side of history.

Re: Current RNA vaccines protect against worrying coronavirus variants

#39
post #18

I hate headlines that try to tell me how I should feel about something. It seems like it would be equally informative without the “worrying”.

It's not telling you to whom it is worrying. You made the mistake of assuming the headline meant "to you" but it is not stated. It is certainly worrying to someone.

Re: Current RNA vaccines protect against worrying coronavirus variants

#40

I literally saw the opposite headline about Pzifer versus a strain in India today The actual article said "modest antibody evading capabilities“ I hate that the internet has become this way

This article doesn't seem to address any of the strains originating in India, fwiw. My guess is that they haven't known of them long enough to understand their reaction in vaccinated people.
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