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Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

pubmed.ncbi.nlm.nih.gov

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Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#41

Post by johnisgood »

sparrc wrote: post #26

It's always strange to me how certain studies seem to gain so many upvotes on hackernews....a few thoughts: 1. This is a single study published in 2015, what does the wider literature say? Any dieticians or clinicians recommending anything from this? 2. The journal is EBioMedicine, which is not nothing but not exactly pre-eminent either. 3. This seems like just a common sense conclusion: "In Cox proportional hazard m…

I suppose emphasis is on this: "telomere length was not a predictor of successful ageing".

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#42

Post by imwillofficial »

NotSammyHagar wrote: post #32
kossTKR wrote: post #8

Earlier quoted context omitted.

Same here. It's the closest thing to an actual wonder drug i have ever come across. My skin clears up, brainfog disappears, the white in my eyes get brighter, etc. After reading a bit i have come to the same conclusion - if your diet is already extremely clean / bland, maybe you won't get the same effect, but for most people that eats lots of different foods, processed stuff, fast food, alcohol, harsh additives, frie…

Come on, don't use the word clean with regards to diet. It's a bs and meaningless word that specifies nothing. Is it no sugar, no salt, no meat, no gc organisms, no alcohol no processed, low carb, high carb? Clean is a word that suggests Instagram influencers. Clean does not mean bland or not bland, whole foods or not. It's a meaningless word like good, healthy, natural.

Subjective meaning is not no meaning. Good absolutely has a meaning. So does healthy, as does natural.

Your lack of understanding of the context of use, and underlying meaning, is nobody's problem but your own.

Perhaps you should have asked what He meant by clean, because clearly you don't understand.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#43

Post by briefcomment »

asadkn wrote: post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

Don't forget environmental factors.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#44

Post by kgin »

Epigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock

What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/articles/s41586-020-2975-4

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#46

Post by perl4ever »

kgin wrote: post #44

Epigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/ar…

>currently the most accurate way to measure aging

I don't understand what people mean by statements like this. Per the Wiki page, they found something that on average is highly correlated to chronological age.

But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise? What is the reference point for the "real" age that is not chronological age?

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#47

Post by fao_ »

perl4ever wrote: post #46
kgin wrote: post #44

Epigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/ar…

>currently the most accurate way to measure aging I don't understand what people mean by statements like this. Per the Wiki page, they found something that on average is highly correlated to chronological age. But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise? What is the reference point for the "real" age that is not chronological age?

> But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise?

Because it was more accurate than other data sources we've tried

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#48

Post by fao_ »

UncleOxidant wrote: post #35
kossTKR wrote: post #8

Earlier quoted context omitted.

Same here. It's the closest thing to an actual wonder drug i have ever come across. My skin clears up, brainfog disappears, the white in my eyes get brighter, etc. After reading a bit i have come to the same conclusion - if your diet is already extremely clean / bland, maybe you won't get the same effect, but for most people that eats lots of different foods, processed stuff, fast food, alcohol, harsh additives, frie…

If I could make it past the first 24 hours of fasting I could probably go further, but I get really bad headaches when fasting and usually give up somewhere close to 24 hours. I hear that if I were to push through for a few more hours that the headache would clear up, but haven't been able to do that yet.

This doesn't tell us anything, and drinking water alone isn't enough. How much and how often did you drink water, and consume salt or rehydration salts. The latter is just as important as the former in keeping your body functioning. If you experience significant salt loss, you will get a headache as your body tries to maintain homeostasis. This is exactly one of the reasons for the headache part of a hangover, and if you adequately replenish your water and electrolytes, you will be vastly less likely to get one.

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#49

Post by kbaker »

NotSammyHagar wrote: post #32
kossTKR wrote: post #8

Earlier quoted context omitted.

Same here. It's the closest thing to an actual wonder drug i have ever come across. My skin clears up, brainfog disappears, the white in my eyes get brighter, etc. After reading a bit i have come to the same conclusion - if your diet is already extremely clean / bland, maybe you won't get the same effect, but for most people that eats lots of different foods, processed stuff, fast food, alcohol, harsh additives, frie…

Come on, don't use the word clean with regards to diet. It's a bs and meaningless word that specifies nothing. Is it no sugar, no salt, no meat, no gc organisms, no alcohol no processed, low carb, high carb? Clean is a word that suggests Instagram influencers. Clean does not mean bland or not bland, whole foods or not. It's a meaningless word like good, healthy, natural.

I mean, they did qualify it in the same sentence with "different foods, processed stuff, fast food, alcohol, harsh additives, fried/burned food etc. on occasion".

Although I don't know any diet that would be "clean" compared with a water fast...

Re: Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age

#50

Post by koolba »

andreygrehov wrote: post #38
asadkn wrote: post #14

Most people talk food when inflammation is mentioned. But let's not forget, arguably, an even bigger contributor: stress - mental or physical, say via a chronic illness. Relevant: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476783/#s2titl...

Curious – are there legitimate ways to measure stress?

You could count the amount of hair loss or lack thereof. I bet hours of nightly REM sleep would be inversely correlated as well.
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