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Psilocybin 'promising' for depression

bbc.co.uk

211–220 of 324 posts

Re: Psilocybin 'promising' for depression

#211

Earlier quoted context omitted.

I have zero experience with drugs, so I am wondering if there is a sugar/cigarette industry that put a lot of money into promoting it's products, then what will be different when drugs get legalized? Won't we repeat the history where companies make billions from this products, put them into ads to spread the use and addict people, suppress research into bad side effects etc,. Personally I think there are some good ap…

Sure, for weed maybe. But psychedelics are very different. They're really, genuinely not addictive -- probably because they're not "fun." In fact, they're exhausting. You may feel a lot better after, the experience may be fascinating, but you're in absolutely no hurry to do it again. The whole thing lasts a few hours, but literally feels like months, with numerous epochs along the way. It's not like the kind of hollo…

>probably because they're not "fun."

You've been doing it wrong ;-) I'm not sure I've ever laughed so much or felt so connected to people. Just thinking about it is making me nostalgic.

Re: Psilocybin 'promising' for depression

#212
post #162

I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…

See also ;

MDMA Solo ; https://news.ycombinator.com/item?id=25974701

“The brain is not a blind, reactive machine, but a complex, sensitive biocomputer that we can program. And if we don't take the responsibility for programming it, then it will be programmed unwittingly by accident or by the social environment.”

Re: Psilocybin 'promising' for depression

#213

Earlier quoted context omitted.

Definitely, however it's also disingenuous to say that we have no idea what the long term consequences of shrooms are just because there hasn't been a formal study recently. There's tons of people doing it regularly - for millennia actually, studies from the before-times and a large incentive by the mainstream anti-drug folks to dramatize any adverse consequences. Should there be studies? Sure. Are we pretty sure it'…

The way to get people to agree with legalization is to follow rigorous medical study procedures, not handwave about it being obviously fine. For the record I think they should be legalized.

We don't have rigorous experimental data on alcohol or nicotine either.

Re: Psilocybin 'promising' for depression

#214
post #162

I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…

This sounds so amazing. I'd probably never try mushrooms though because I'm terrified of them rewiring my brain in some messed up way.

Re: Psilocybin 'promising' for depression

#215
post #162

I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…

What's your take on allowing a substance to change you so much?

To me, I don't think it's so much about "change" as having your normal day to day experience being clouded by so much emotional pain, conditioning, trauma, rationalization, etc. If you can take a step back from all that, you can understand your deeper feelings.

Re: Psilocybin 'promising' for depression

#216

Earlier quoted context omitted.

The way to get people to agree with legalization is to follow rigorous medical study procedures, not handwave about it being obviously fine. For the record I think they should be legalized.

I tend to believe that unless proven otherwise, substances should be legal. The burden of proof IMO is on the folks who want to restrain behavior. [edit] I don't think that producing a study that shows a lack of harm is going to change anyone's mind. The prohibition is puritanical and ideological, no amount of evidence is going to change that. I think if this was based on a genuine fear, the study would have preceded…

> We already know the LD-50 of mushrooms is 17kg of fresh mushroom for an average size human lol.

Curious as to how we know... has anyone ever OD'd on psylocibin?

Re: Psilocybin 'promising' for depression

#217
post #91
post #52

I feel like there will also people that have way too many prejudices towards these kinds of "drugs" because that's simply how we learned it. "Don't take drugs kids". These studies are very helpful especially when shared over general media, but the consumption has to be supervised and controlled to not have overdoses and ruin the whole reputation again. It should be treated like any other anti-depressant, since they a…

We need to change the message from "don't take drugs" to "if you choose to take drugs, take them responsibly". Start with low doses, don't mix (alcohol,benzo,opiates), and remember that unless taken therapeutically, drugs should be an occasional party thing and not an escapism for life. It's also totally fine to not do drugs. I'm going sober (except a beer or two) for an indefinite period of time, just because that's…

> drugs should be an occasional party thing

Please don't! If all this research thought us anything, it's that powerful substances are emotional surgery. Not something to attempt in an unsafe environment.

Re: Psilocybin 'promising' for depression

#218
post #123
post #26

On the one hand, HN is terrified of brain-computer interfaces manipulating our brains and emotions, on the other hand, they're totally psyched about using mushrooms to do the same thing.

Mushrooms don't have an agenda. The owner of the brain-computer interface probably does.

The jury is out on that. There are mushrooms that infect ants' brains and make them travel to a high place before the ant's head explodes, so that the spores are carried further by the wind.

They might have an agenda.

Re: Psilocybin 'promising' for depression

#219
post #19

Earlier quoted context omitted.

I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.

Why is this being downvoted? Studies are great, but let's not act like drugs are suddenly safe to use in all cases. I'm sure the studies didn't conclude that. Be pro-shrooms but don't act like they're safe in every case. Education is required before partaking in anything, let alone shrooms.

Can we point to any data showing that mushrooms or acid (for example) are more dangerous than, say, a coronavirus vaccine or driving a car?

Because generally speaking, unless something is concretely documented as dangerous we don't just assume it is dangerous "because". Especially when that "because" is because of a well-documented, decades-long propaganda campaign by the federal government.

Re: Psilocybin 'promising' for depression

#220

For those curious: you can cultivate your own at home. It’s 100% legal to purchase psilocybin spores online in many states. I just had to throw out a grow due to contamination - super frustrating setback - but I’m determined to produce a healthy harvest.

It's a shame that former MP and Home Office Minister Caroline Flint decided to reclassify psilocybin as a "Class A" drug alongside heroin and cocaine despite no evidence of it causing psychosis.

That really was the peak of New Labour's evidence-less led drugs reforms.

[1] - https://www.theguardian.com/uk/2005/jun/25/drugsandalcohol.i...

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