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Suppressing a gene by using its antibody can lead to tooth growth: animal study

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Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#111

Post by causality0 »

Jarwain wrote: post #50
causality0 wrote: post #24

Earlier quoted context omitted.

It codes for one protein, and experiments have turned it on and off in other animals. Turning it off benefited humans by increasing the amount of fructose stored as fat during a time when climate change reduced the availability of fruit. In light of our ridiculous modern caloric intake, turning it back on isn't likely to lead to problems.

Do you have a source for this? Not asking out of doubt, but curiosity

Kratzer, J., Lanaspa, M., Murphy, M., Cicerchi, C., Graves, C., Tipton, P., Ortlund, E., Johnson, R. and Gaucher, E., 2014. Evolutionary history and metabolic insights of ancient mammalian uricases. Proceedings of the National Academy of Sciences, 111(10), pp.3763-3768

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#112

Post by Tade0 »

kleiba wrote: post #98
mdpopescu wrote: post #94

Earlier quoted context omitted.

As a general rule, the entire medical profession has the incentives set up the wrong way - the more problems you have, the more they benefit. I have read that there was a time, in the distant past, where you paid a doctor only as long as you were healthy. I can come up with some problems even in that case, but I can't help but think it might still be an improvement over the current situation...

there was a time, in the distant past, where you paid a doctor only as long as you were healthy This sounds implausible, and even if it were true it would not be very fair: it's usually not the doctor's fault when you've got some medical issue, so why should s/he suffer from that financially?

Also it creates a major incentive to disregard diseases.

What follows is that a dead patient, while not a source of income, is at the same time not a source of costs.

I don't see how such an arrangement could work long-term.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#113

Post by refurb »

preciz wrote: post #102
refurb wrote: post #67

Earlier quoted context omitted.

Yet one of the biggest selling products ever was a cure for hepatitis C. Pharma hiding cures is internet BS.

That is one example that was interpreted by you to be valid for all other cases? Seeing your other comments I think you highly trust the medical system. Never trust blindly my friend.

Please give an example of a cure that has been hidden by pharma. I'm all ears.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#114

Post by inter_netuser »

seer wrote: post #105
mdpopescu wrote: post #94

Earlier quoted context omitted.

As a general rule, the entire medical profession has the incentives set up the wrong way - the more problems you have, the more they benefit. I have read that there was a time, in the distant past, where you paid a doctor only as long as you were healthy. I can come up with some problems even in that case, but I can't help but think it might still be an improvement over the current situation...

I think I’ve read somewhere about this being an old Chinese tradition. They would pay doctors for the amount pf people he is looking after, and he has the incentive to keep his “flock” healthy as that would mean much less work for him.

It is common today too.

https://en.wikipedia.org/wiki/Capitation_(healthcare)

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#115

Post by teekert »

refurb wrote: post #67
dannyw wrote: post #33

Earlier quoted context omitted.

I don't know. We see pharma companies killing one-time cures to not cannibalise recurring treatments, even if another company makes the recurring treatments.

Yet one of the biggest selling products ever was a cure for hepatitis C. Pharma hiding cures is internet BS.

I believe so too, it would also simply require too many good people in labs all around te world to not say anything about it. I find that highly unlikely.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#116

Post by fmsf »

fmsf wrote: post #93

these guys found a polypeptide that can repair enamel but they aren't very well known https://www.curodont.com/ edit: correct link for the enamel thingie is this -> https://www.curodont-professional.com/ . I remember seeing some papers from them justifying this, but cant' find them

ocd kicked in and ended up drilling through their site till I found the list of papers https://www.curodont-professional.com/wp-content/uploads/202...

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#117

Post by _0ffh »

Tade0 wrote: post #112
kleiba wrote: post #98

Earlier quoted context omitted.

there was a time, in the distant past, where you paid a doctor only as long as you were healthy This sounds implausible, and even if it were true it would not be very fair: it's usually not the doctor's fault when you've got some medical issue, so why should s/he suffer from that financially?

Also it creates a major incentive to disregard diseases. What follows is that a dead patient, while not a source of income, is at the same time not a source of costs. I don't see how such an arrangement could work long-term.

Right. I think I remember it used to be normal in some societies to pay the doctor only if he managed to cure you. That sounds much more plausible. Paying for the state transition from sick to okay should work just fine.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#119

Post by hutzlibu »

throwawayboise wrote: post #5
Jeff_Brown wrote: post #2

The article linked says it causes new teeth to grow in rats and ferrets, and that pugs and dogs are next. It doesn't however talk about targeting that growth to a particular place.

Don't rodent teeth grow continuously anyway? That's why they're always gnawing on stuff.

Your teeth are growing a bit, too. (Otherwise they would be grinded down, too)

But this is about regrowing a lost tooth.

Re: Suppressing a gene by using its antibody can lead to tooth growth: animal study

#120

Post by raducu »

NiceWayToDoIT wrote: post #92

Although amazing, I am following similar news for last 20 years, and promise of tooth regrowth was as a holly grail of dental health, but on the other side it is similar like a nuclear fusion always 20 years away. Process goes like this, "big news -> excitement -> and then nothing -> few years later again nothing -> you go to you dentist for regular check and when you ask he laughs in your face." I read about steam c…

Because any regrowth solution would be quite expensive, time consuming and prone to problems.

It would likely be performed by surgeons and monitored by orthodontists there couls be multiple teeth comming out, missaligned and so forth.

I'd much rather do things the old fashion way than risk all sorts of problem down the line, have multiple trips, wait months upon months for my teeth to regrow.

As a last resort, or instead of an implant, yeah, sure! But afik, the money you pay for materials are smaller than the surgeon's fee, so I see no incentive for a surgeon not to give you natural teeth if he could.

It could be that he'd make more money that, way, less checkups and so on.

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