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Microdosing study shows the placebo effect of taking psychelics

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21–30 of 114 posts

Re: Microdosing study shows the placebo effect of taking psychelics

#21
post #4

To the people illegally micro-dosing: Why would you open yourself up to the liability of committing a felony crime for a placebo effect? The risk vs reward doesn’t seem to pan out for me.

It's a felony to store ANY pills outside of their original container.

Re: Microdosing study shows the placebo effect of taking psychelics

#23
post #4

To the people illegally micro-dosing: Why would you open yourself up to the liability of committing a felony crime for a placebo effect? The risk vs reward doesn’t seem to pan out for me.

I know a lot of people who have done psychedelics and I don’t think any of them have ever been prosecuted for possessing them. I’ve only ever heard of that happening to dealers. In my head, possession is in the same category as speeding or downloading movies.

I don’t have statistics to back this up, and it could be a reflection of the privilege of my social group.

Re: Microdosing study shows the placebo effect of taking psychelics

#24

> Meanwhile, those who consumed the drugs but thought they were taking a placebo experienced no significant increase in wellbeing. It's wild that there was a part of this study in which people were told that they weren't taking a psychadelic, but they were taking a psychadelic.

MKUltra vibes

Re: Microdosing study shows the placebo effect of taking psychelics

#26
post #20

My drug of choice is placebo. Minimal side effects. Inexpensive. The more I use it, the better it works. Has effects on a variety of ailments, both physical and psychological. I'm surprised they don't sell branded placebo at the pharmacy - "Super Placebo - now with organic filler". I think it could be a hot seller.

It's called homeopathy.

Re: Microdosing study shows the placebo effect of taking psychelics

#27
post #16

There is a similar effect when consuming alcoholic drinks in social settings: https://link.springer.com/article/10.1007/s11469-020-00321-0 > “Our study confirms the benefits of microdosing,..." This is really horrible phrasing since normal the normal usage of the term "benefits" in this context would mean benefits relative to a placebo. In this experiments the benefits are zero since the LSD and control pills had the…

There are arguments that the placebo effect plays a large role in the observed treatment effects of psychedelics.

One of the hallmarks of psychedelics is a (drug induced) sense of profundity and enlightenment. If you tell someone that they're about to have a life-changing experience, then you give them a drug that induces the feeling of a life-changing experience, it's likely that they'll walk away thinking they've had a life-changing experience and change their behavior accordingly.

I agree that their conclusion is borderline misleading. Traditional antidepressant studies also show a high placebo response rate, but approved SSRIs diverge from placebo in studies. Their success is largely measured by how far they diverge from the placebo groups.

If an SSRI study showed that the medications were identical to placebo yet concluded that the SSRIs had benefit, it would be soundly rejected. Yet when the same conclusion appears in a study about psychedelics, it seems to get a free pass. I think this speaks volumes about the current bias toward psychedelic medicine.

Re: Microdosing study shows the placebo effect of taking psychelics

#28

> Meanwhile, those who consumed the drugs but thought they were taking a placebo experienced no significant increase in wellbeing. It's wild that there was a part of this study in which people were told that they weren't taking a psychadelic, but they were taking a psychadelic.

I'm just going off of the title, but I would expect microdosing to naturally involve only small effects.

Re: Microdosing study shows the placebo effect of taking psychelics

#29

> Meanwhile, those who consumed the drugs but thought they were taking a placebo experienced no significant increase in wellbeing. It's wild that there was a part of this study in which people were told that they weren't taking a psychadelic, but they were taking a psychadelic.

I wonder how they passed IRB review. Did the doctors literally tell them "we're giving you nothing" or "you probably got nothing". The first seems like it wouldn't pass review these days...

Re: Microdosing study shows the placebo effect of taking psychelics

#30
post #4

To the people illegally micro-dosing: Why would you open yourself up to the liability of committing a felony crime for a placebo effect? The risk vs reward doesn’t seem to pan out for me.

Micro-dosing also feels quite nice. It has a major mood-brightening effect. It's the main reason I do it. I don't even think it improves work at all. But if you're happier you might do better work.

How's the comedown? Any anxiety?
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