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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

nature.com

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Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#91

Post by jcynix »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

Raw fruit isn't a problem, not even for humans. Products where "sugar" is replaced by fructose or other, simpler sugar variants is. Various sugar substitutes are added to e.g. canned fruit in "juice" which is mostly some kind of sugar. Which lets marketing say "less sugar" ...

And "high fructose corn syrup" is ... almost pure fructose. Which the human liver can only process a limited amount per day.

Anecdote: a young guy in Freiburg (Germany) got Covid recently and as a result lost his sense of taste afterwards. Now he isn't interested in fast food any more as everything tasty "bland" and can "easily" eat vegetables which he disliked before, even broccoli or Brussels sprouts. Which made him loose more than 50 pounds. Don't get this wrong, it's not an incentive to get Covid, but an example of the effects of abstaining from fast food and soft drinks.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#92

Post by hnuser123456 »

tp3 wrote: post #28
foxyv wrote: post #10

Earlier quoted context omitted.

Table sugar is entirely made up of sucrose. A polymer which is composed of one glucose molecule and one fructose molecule. Fructose is also in most fruit sugars. Honey is one of the worst offenders from a natural source. Finally corn syrup is the absolute worst. Avoiding refined sugars in general is a good thing, but removing fructose completely would require not eating any fruits or berries either. The rule of thumb…

I think most Americans are doing just fine with high fructose diets. However, there have been a lot of studies coming out, that seem to be suggesting there is some danger of obesity after a certain low carbohydrate diet or skipping carbohydrates altogether, as these diets tend to spike blood sugar rapidly. The most interesting is a study in humans, that showed a significant increase in blood glucose when carbohydrate…

How in the world would eating less carbs lead to an increase in blood sugar? You must have something backwards. Eating more protein and fat instead of carbs should certainly lead to a decrease in blood sugar.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#93

Post by jcynix »

4ec0755f5522 wrote: post #65
leephillips wrote: post #45

Earlier quoted context omitted.

But don’t all other primates eat lots of fruit? Why are humans unique?

Does fruit contain as much fructose today as it did 50, 100, 200 years ago? Or have we selectively bread the sweetest fruits to the point where monkeys cannot eat bananas? Monkeys banned from eating bananas at Devon zoo Zookeepers say the stereotypical food actually makes monkeys more aggressive, rots their teeth and can lead to diabetes [...] Zookeepers said the fruit grown and exported for human consumption have fa…

> Does fruit contain as much fructose today as it did 50, 100, 200 years ago?

Maybe due to selection of larger, sweeter fruit, yes. But processed food contains various sugar variants, including fructose (think "high fructose corn syrup") so fruit isn't the only (not even the main) source of fructose for many.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#94

Post by hnuser123456 »

tp3 wrote: post #34
nradov wrote: post #13

Earlier quoted context omitted.

Honey appears to have some other beneficial properties. There is no real evidence that moderate honey consumption causes worse health outcomes.

I eat a lot of honey, and am a huge fan of maple syrup. I love maple syrup, but I eat it in moderation. I eat it in smaller portions of about half cup daily but can have as much as I want. It's good on it's own as an energy source, and can be used as a natural sweetener. Also, I like to eat my whole grain breads with maple syrup as well. It adds flavor to them, so maybe I should add some! It's easy to eat, and is eas…

That is a lot of pure carbs and no protein or fat. All of your comments seem to be suggesting this diet. "Whole grain" is the only healthy part of your comment.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#95

Post by aszantu »

jcynix wrote: post #91
leephillips wrote: post #45

Earlier quoted context omitted.

But don’t all other primates eat lots of fruit? Why are humans unique?

Raw fruit isn't a problem, not even for humans. Products where "sugar" is replaced by fructose or other, simpler sugar variants is. Various sugar substitutes are added to e.g. canned fruit in "juice" which is mostly some kind of sugar. Which lets marketing say "less sugar" ... And "high fructose corn syrup" is ... almost pure fructose. Which the human liver can only process a limited amount per day. Anecdote: a young…

maybe I should get magicberry tabs again, they make everything taste sweet (more like aspartam sweet) without actually giving you sugar

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#96

Post by hnuser123456 »

poopoopeepee wrote: post #66
airhead969 wrote: post #57

Earlier quoted context omitted.

Well, can't we buy some and keep it? I know the fresh stuff is tasty, but let's not go Winnie the Pooh. :)

> rare and seasonal in nature I don't know what else to add. You've gone too far off the path. It's pretty simple what OP wrote. Makes a person think about nature, evolution, adaption, is-this-healthy. Ok?

It's pretty well known honey has an extremely long shelf life due to anti-bacterial substances not found in other sources of sugar.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#98

Post by jcynix »

electrograv wrote: post #27
tp3 wrote: post #17

Earlier quoted context omitted.

A diet high in fructose is not advisable for people with an autoimmune disease. One study did that of people with a large number of specific types of autoimmune disease that can be caused by high fructose foods. This study showed that one diet was associated with a higher incidence of these autoimmune diseases in those with large and consistent levels of fructose intake. For example, in those with low body weight you…

Question: Does this mean honey and high fructose corn syrup are approximately equally [1] unhealthy? Or is honey an anomaly/enigma [2] in this respect? [1] Apparently honey contains ~40% fructose, which about the same as “HFCS42” (a standard 42% fructose corn syrup product). [2] I ask this because I’ve read many claims that honey is among the healthiest forms of sugar, with many studies cited that show all sorts of h…

Fluid honey mainly is fructose, the one which crystalizes easily is mainly glucose.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#99

Post by byerobh »

I mean the methodology is sketch and even the assumptions seem quite not right. Correct me but might as well read: "Fructose increases metabolism and degradation of poison (LPS)"

Sure in the context of the particularly bad diets 98% of Americans eat (odds are you're not in this 2% hon), excess fructose might be bad. But look at the research in primates, other countries, fructose in a nutrient rich diet is plain fuel for metabolism and repair. Hell, even fertility is improved.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#100

Post by theNJR »

baxtr wrote: post #77

Sugar is bad, oil is bad, salt is bad, meat is bad, fruits are now bad too. What can you eat?

Only some oils are bad. Avoid oils used at fast food restaurants and in packaged goods. Olive and avocado are good.

Salt isnt bad.

Meat can be fine. Just be careful of its source, frequency of consumption and method of cooking.

Fruit is sugar, which is bad.

Focus on eating a ton of veg, locally sourced when possible, and the most expensive lean proteins you can afford.

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