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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

nature.com

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Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#41

Post by dmfdmf »

hourislate wrote: post #30
foxyv wrote: post #10

Earlier quoted context omitted.

Table sugar is entirely made up of sucrose. A polymer which is composed of one glucose molecule and one fructose molecule. Fructose is also in most fruit sugars. Honey is one of the worst offenders from a natural source. Finally corn syrup is the absolute worst. Avoiding refined sugars in general is a good thing, but removing fructose completely would require not eating any fruits or berries either. The rule of thumb…

In addition to your comment, Sugar/Sucrose can be processed by your entire body. Fructose can only be processed by your liver. Consuming too much Fructose (easy to do), is not a good thing for your Liver.

Sugar is a bonded pair of fructose and glucose. In the stomach an enzyme breaks the bond and both sugars are absorbed. Glucose can be used by any cell but fructose is processed by the liver. It seems that fructose is what is disturbing blood and metabolism.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#42

Post by kat »

electrograv wrote: post #27
tp3 wrote: post #17

Earlier quoted context omitted.

A diet high in fructose is not advisable for people with an autoimmune disease. One study did that of people with a large number of specific types of autoimmune disease that can be caused by high fructose foods. This study showed that one diet was associated with a higher incidence of these autoimmune diseases in those with large and consistent levels of fructose intake. For example, in those with low body weight you…

Question: Does this mean honey and high fructose corn syrup are approximately equally [1] unhealthy? Or is honey an anomaly/enigma [2] in this respect? [1] Apparently honey contains ~40% fructose, which about the same as “HFCS42” (a standard 42% fructose corn syrup product). [2] I ask this because I’ve read many claims that honey is among the healthiest forms of sugar, with many studies cited that show all sorts of h…

[1] Honey is bad if you've got issues digesting fructose. For someone with IBS, or another digestive issue, the FODMAP diet recommends no more than 1 teaspoon of honey with a meal (ie every 4 hours). The FODMAP diet tracks fructose-in-excess-of-glucose as that is one of the common triggers of digestive issues. Its not saying that honey is unhealthy, but rather honey causes issues for some folks.

Here's more about sweeteners on the FODMAP diet (RN reviewed too!) https://alittlebityummy.com/the-ultimate-guide-to-low-fodmap...

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#43

Post by akurzon »

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere.

https://youtu.be/dBnniua6-oM

https://youtu.be/ceFyF9px20Y

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#44

Post by rorykoehler »

electrograv wrote: post #27
tp3 wrote: post #17

Earlier quoted context omitted.

A diet high in fructose is not advisable for people with an autoimmune disease. One study did that of people with a large number of specific types of autoimmune disease that can be caused by high fructose foods. This study showed that one diet was associated with a higher incidence of these autoimmune diseases in those with large and consistent levels of fructose intake. For example, in those with low body weight you…

Question: Does this mean honey and high fructose corn syrup are approximately equally [1] unhealthy? Or is honey an anomaly/enigma [2] in this respect? [1] Apparently honey contains ~40% fructose, which about the same as “HFCS42” (a standard 42% fructose corn syrup product). [2] I ask this because I’ve read many claims that honey is among the healthiest forms of sugar, with many studies cited that show all sorts of h…

It’s not the source of the fructose that matters (at least not much). My autoimmune processes go into overdrive due to biome activity that is exacerbated by all sugars including carbs. The source of the sugar is of second order importance.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#45

Post by leephillips »

akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#46

Post by rorykoehler »

oudhmkbjx wrote: post #33
electrograv wrote: post #27

Earlier quoted context omitted.

Question: Does this mean honey and high fructose corn syrup are approximately equally [1] unhealthy? Or is honey an anomaly/enigma [2] in this respect? [1] Apparently honey contains ~40% fructose, which about the same as “HFCS42” (a standard 42% fructose corn syrup product). [2] I ask this because I’ve read many claims that honey is among the healthiest forms of sugar, with many studies cited that show all sorts of h…

This depends a great deal on the quality of honey. Most honey at the supermarket is adulterated [1]. If you can find raw, unfiltered honey, then it will contain additives such as pollen, beeswax, and parts of bees. The additives have nutritional value, yes, but the overwhelming majority of honey is the nutritional equivalent of simple syrup. Probably the "best" sugar you can use is date sugar, which is just dried, gr…

My brother keeps his own bees who pollinate wild flowers. His honey still triggers an auto inflammatory response in me.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#47

Post by narrator »

HFCS is just about the worst food ingredient out there that is present in foods in amounts larger than a couple of milligrams. Maybe trans-fats are worse, but those have been largely phased out. In 2009, sampled foods with HFCS had detectable levels of mercury, though corn refiners claim this is fixed and due to an outdated refining process that used mercury.

https://www.webmd.com/food-recipes/news/20090127/mercury-in-...

That's on top of all the other negative health effects like diabetes, metabolic syndrome, etc.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#48

Post by TACIXAT »

tp3 wrote: post #28
foxyv wrote: post #10

Earlier quoted context omitted.

Table sugar is entirely made up of sucrose. A polymer which is composed of one glucose molecule and one fructose molecule. Fructose is also in most fruit sugars. Honey is one of the worst offenders from a natural source. Finally corn syrup is the absolute worst. Avoiding refined sugars in general is a good thing, but removing fructose completely would require not eating any fruits or berries either. The rule of thumb…

I think most Americans are doing just fine with high fructose diets. However, there have been a lot of studies coming out, that seem to be suggesting there is some danger of obesity after a certain low carbohydrate diet or skipping carbohydrates altogether, as these diets tend to spike blood sugar rapidly. The most interesting is a study in humans, that showed a significant increase in blood glucose when carbohydrate…

>I think most Americans are doing just fine with high fructose diets.

Most Americans are overweight. I wouldn't call that doing fine.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#49

Post by simcop2387 »

leephillips wrote: post #45
akurzon wrote: post #43

For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. https://youtu.be/dBnniua6-oM https://youtu.be/ceFyF9px20Y

But don’t all other primates eat lots of fruit? Why are humans unique?

No research done, but I suspect it's because of the sheer amount that we consume, at least in the US due to the use of corn syrup in packaged foods.

Re: Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS

#50

Post by leephillips »

simcop2387 wrote: post #49
leephillips wrote: post #45

Earlier quoted context omitted.

But don’t all other primates eat lots of fruit? Why are humans unique?

No research done, but I suspect it's because of the sheer amount that we consume, at least in the US due to the use of corn syrup in packaged foods.

Sure, but that’s not the question. Presumably gorging on HFCS would be bad for chimps, too. I was asking about the claim that “fructose” is unhealthy.
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