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Our brutal science system almost cost us a pioneer of mRNA vaccines

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Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#271
post #115

Earlier quoted context omitted.

> The grant system completely compromises most faculty'$ ability to do anything with their decades of training besides sell themselves. I agree that the academic world is broken, but this narrative that success -- in any field -- isn't dependent on your ability to sell yourself is problematic. I left academia behind because I saw that it was a brutal, improbable grind, sure, but mainly because I could see that the sa…

> but this narrative that success -- in any field -- isn't dependent on your ability to sell yourself is problematic. Some people make fantastic researchers and are terrible at selling themselves and their work. It seems like a bad deal for everyone if these people are blocked from making contributions to science.

> Some people make fantastic researchers and are terrible at selling themselves and their work. It seems like a bad deal for everyone if these people are blocked from making contributions to science.

Sure...lots of people make fantastic technical workers, and are terrible at selling themselves and their work. I'm not denying their existence. I'm saying that academia is an organization made up of humans, and as such, has the same bias toward self-promotion and social skills as any other field. At the end of the day, people make the decision of who get to be professors, get grants, and so on. Success in an academic discipline, for most people, is about being known, liked and respected amongst the small circle of colleagues who dominate that discipline.

The mythology I am combatting here is that academia was ever this magical unicorn land where introverts and brilliant weirdos can prosper. It happens more often than some fields, I guess, but mostly the same social dynamics apply. It's kind of the same wishful thinking you see from brilliant engineers who can't work on a team -- they invariably stop progressing, and wonder why they don't get promoted up the technical ladder. They can still contribute in the area of their greatest skill, but they're limited in the long run by their social abilities.

It's really common to see brilliant people with no interpersonal skills wash out in grad school. It's almost a cliché. The ones who do make it, rarely advance to a professorship -- they'll get stuck at postdoc or staff scientist or something like that, because some professor is more than willing to keep them around, hidden in the lab, for their exceptional technical skill.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#272
post #75

Earlier quoted context omitted.

It seems like this is exactly the kind of thing that a government is useful for. Why not have more publicly funded research institutions that employ them, and put them to work on useful research without having them worry about grant considerations, teaching classes, or the publishing treadmill?

They're called the national labs, and they're pretty awesome.

Academic labs on steroids.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#273
post #78

Earlier quoted context omitted.

That's been a question I have no answer to: What do we do with all these smart people? Currently most just go inside hierarchical workplaces where they have to learn to play office politics and carry out meaningless job functions in exchange for financial security. We don't have a Bell labs anymore, science is getting more expensive and most of the venture capital money goes to software rather than to the more capita…

Bell Labs was one organization. While it's always a big blurry how much pure research goes on at corporate research labs, I'm not sure there isn't as much research going on today than there ever was given all the money especially in software out there. Hard to measure as I say, but I think it was maybe the 80s going into the 90s that a lot of the old-style corporate research labs were going out of fashion and nothing…

The Reagan Recession was brutal.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#274
post #72

Earlier quoted context omitted.

Maybe we don't need all those PhDs, and we should stop funnelling public money into producing an excess supply of them?

On of the effects of training too many PhDs is downward pressure on academics' salaries - i.e. the public gets their science results on the cheap.

The public fails to get much science at all, not because they or the scientists are cheap, just neither one can afford the things that were always expceted to be within reach any more.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#275

Earlier quoted context omitted.

I've heard this dream a few times, and have had it myself. Hazardous waste disposal and storage. This is the big kicker for any research project I might want to do. Every other expenses after getting that set up is trivial (in comparison) for an individual researcher, though national lab style shared analytical equipment is nice. That can come later though... It's really hard. It's much simpler to set up a machine sh…

>Hazardous waste disposal and storage. Partner with a hazardous material testing lab, or another type of operation where they use lots of hazardous material similar to yours and end up turning a bit of it into waste themselves. Not necessarily an environmental lab where they actually test waste , better an industrial lab that tests material . Some better opportunities can even be with material or waste handlers who h…

> Hazardous material does not become hazardous waste if you can legitimately sell/ship it off the site as a worthwhile product instead. Otherwise if you need to truly discard excess (even prime chemical assets then become a liability) you need to not only usually pay, but bump your paperwork and liability up from merely dangerous goods to full waste documentation requirements.

This is what I meant. For a small organization I would expect a lot of small volume experimental products that are not exactly known in composition combined with perhaps some rinse acetone or other solvents.

Have you encountered an example where this works? I've done consulting for startups in exchange for a fume hood before, so I guess it's not that out there. It's much harder to imagine doing this for a big hazardous waste site, but maybe?

Thanks for the idea, I definitely won't be trying to do that but maybe there could be a symbiotic thing going on there. Probably a lot easier to do that with a university somehow? A national lab will be too stuck up to accept hazardous waste or advice, but maybe a university would hire you part time to work for them while letting you use the space for your own project.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#276

Earlier quoted context omitted.

I have continued to publish and never have I been instructed to make the papers be open access. No one is enforcing that mandate. The research I've been a part of is wholly funded by the taxpayer and papers that I published after the mandate continue to not be freely available.

Umm...not sure what to tell you about that, other than you’re potentially out of compliance with the terms you and your institution agreed to. I think there is a 6-12 month “exclusivity” period still, and some journals handle that automatically if you acknowledge federal funding. For example, Current Biology moved our stuff out from behind the paywall automatically on its publication anniversary. - Here’s the NIH pol…

Yeah, no one from up top has brought it up. There's no enforcement. It's just cheap talk.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#277

Earlier quoted context omitted.

>Hazardous waste disposal and storage. Partner with a hazardous material testing lab, or another type of operation where they use lots of hazardous material similar to yours and end up turning a bit of it into waste themselves. Not necessarily an environmental lab where they actually test waste , better an industrial lab that tests material . Some better opportunities can even be with material or waste handlers who h…

> Hazardous material does not become hazardous waste if you can legitimately sell/ship it off the site as a worthwhile product instead. Otherwise if you need to truly discard excess (even prime chemical assets then become a liability) you need to not only usually pay, but bump your paperwork and liability up from merely dangerous goods to full waste documentation requirements. This is what I meant. For a small organi…

Yup, I'm moving toward "retiring" from my employer and doing without a lab for a bit as I decide to get back into more action than the employer can muster.

I'll be able to maintain a good relationship with them and if I do go back into private practice nearby they will be able to handle the few liters a month I would expect to generate single-handedly.

Which is a drop in the bucket of their few drums, which are a drop in the bucket of the EPA waste hauler's truckloads.

Unknowns-R-Us.

OTOH the only time I went without a lab I built, was 2013 and I was tempted to try and operate in some vacant small-university space in my late father's retirement location, but I did not have the resources to _branch out_ while I still had my main lab in mothballs.

Things were also very uncertain plus one of the surplus spaces had already been unfavorably occupied by a not-very-well liked commercial EPA testing lab that I think failed just a year or two earlier and left everyone involved with a bad impression.

Now after recovering a bit from natural disaster, I'm going to check out UH where they took over the old Schlumberger facility as part of their energy effort a number of years ago. It still seems not fully occupied but I'll find out for sure eventually. Before the internet I sure spent a lot of time in the UH library.

When it comes to an actual university operation though, about half the time when I check out a chem department's equipment it looks like they sure could use some help from someone with more than just a few years on the gear, and often so underequipped I could bring in & restore the surplus electonics to double their capabilities within a year not much differently than at a commercial lab. Also without a PhD there are actually some long-term employment or career positions already funded which could be conformed creatively to this effort. If I did this I would want to hit successive universities since I am very fast, but I am mainly retiring from employment more so than my present employer's facility which I expect to routinely continue to visit as long as I am in their areas, to our mutual advantage.

I started out as a teenage businessman anyway so I'm not worried about going forward with only a briefcase again.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#278

Earlier quoted context omitted.

Yes, you're right, the German system is a bit weird. In a nutshell: At the end of primary school your primary teacher recommends whether you should go to Hauptschule, Realschule, or Gymnasium. H. and R. ends after year 10 after which you're supposed to go to vocational school, but you can also switch to G if you're good enough. G ends after year 13 after which you can go to vocational school or university. H and R ca…

This is generally correct and a huge problem. Note that the details of the process differ quite a bit depending on federal state and decade. What may differ are things like duration of Gymnasium, whether recommendations are binding, whether there's a clear distinction between Hauptschule and Realschule, duration of primary school (e.g. 4 or 6 years), how easy it is to switch etc. In my case, primary school was 4 year…

I'd like to add that in some states (e. g. Bavaria) it is very hard to change to a higher track (especially Gymnasium) after the decision in 4th grade. The importance of that decision on later life is hard to underestimate.

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#279

Earlier quoted context omitted.

I love this idea. A 'lab space' instead of a maker space. If someone is going to do this in NL then I'd be happy to help fund it.

Are you near Rotterdam?

Hilversum

Re: Our brutal science system almost cost us a pioneer of mRNA vaccines

#280
This is probably going to be unpopular on this forum, but why is everyone assuming that having more researchers is desirable / needed in the first place?

I think scientific research is completely bloated already and there's no need to provide work for even more researchers who will either (1) research an already popular subject where ever growing funding yields ever disminishing returns or (2) research an utterly futile subject that serves no purpose beside justifying the researcher's salary.

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