Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Body on a 3-day fast: Real-time data with Basis

basishealth.io

Post reply on HN
Print view View original

61–70 of 74 posts

Re: Body on a 3-day fast: Real-time data with Basis

#61

Post by ivanhoe »

cowsandmilk wrote: post #20
ivanhoe wrote: post #14

Earlier quoted context omitted.

There's now a number of studies on effects of fasting on chemo therapy patients, and they all make the same claim of regeneration through autophagy for some types of leukocytes.

If so, why not cite those?

Because it's easy to google it, and I don't have that much free time... these links are on a first page of google results when you search it:

Effects on stem-cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/

Reducing toxicity of chemo therapy: https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-...

clinical trials on humans: https://clinicaltrials.gov/ct2/show/NCT01175837

Re: Body on a 3-day fast: Real-time data with Basis

#62

Post by ivanhoe »

im3w1l wrote: post #37
peteretep wrote: post #11

> At the 3-day mark, I've hit a key milestone in cellular regeneration. My body has broken down old immune cells and generated new ones (Cheng et al., 2014). ... if you were a mouse. Here's the article being referenced: https://pubmed.ncbi.nlm.nih.gov/24905167/

So... is it good to break down old immune cells?

It's not about just randomly breaking the cells, it's a normal process called autophagy where damaged cells are being recycled to be replaced by new ones. This happens all the time, but it seems that fasting can increase it significantly. The leukocyte count only temporarily falls, and then gets back to normal. This is extremely beneficial to chemo therapy patients because chemo damages cells, suppressing the immune system as a side-effect and also makes people feel very sick. This can reduce these effects.

Re: Body on a 3-day fast: Real-time data with Basis

#63

Post by ivanhoe »

peteretep wrote: post #15
ivanhoe wrote: post #14

Earlier quoted context omitted.

There's now a number of studies on effects of fasting on chemo therapy patients, and they all make the same claim of regeneration through autophagy for some types of leukocytes.

Could you explain how this is used to support statements like: > I've hit a key milestone in cellular regeneration What's key about it? In what way is it a milestone? What's the expected health impact in human patients?

Well, if he was a mouse you still would have those same questions in the air until you do the proper blood tests, right?

Of course this is a naive, over-simplified interpretation of science findings, but it doesn't mean the science it's inspired by is bad.

One thing that I couldn't find any research on is what are the effects of repeated fasting cycles (and that's how most of people do it now). Traditional fasting is something you do few times a year, and then you have a recovery period afterwards. Can't find that research now, but I remember reading a paper saying that it takes about 2 weeks of normal food intake to get back to the initial white blood cells counts. What happens if you don't let the body recover and instead create a new calorie deficit stress seems unclear?

Re: Body on a 3-day fast: Real-time data with Basis

#64

Post by peteretep »

ivanhoe wrote: post #63
peteretep wrote: post #15

Earlier quoted context omitted.

Could you explain how this is used to support statements like: > I've hit a key milestone in cellular regeneration What's key about it? In what way is it a milestone? What's the expected health impact in human patients?

Well, if he was a mouse you still would have those same questions in the air until you do the proper blood tests, right? Of course this is a naive, over-simplified interpretation of science findings, but it doesn't mean the science it's inspired by is bad. One thing that I couldn't find any research on is what are the effects of repeated fasting cycles (and that's how most of people do it now). Traditional fasting is…

> Of course this is a naive, over-simplified interpretation of science findings, but it doesn't mean the science it's inspired by is bad.

I am complaining entirely and exclusively about the interpretation, I’m sure the science is fine.

Re: Body on a 3-day fast: Real-time data with Basis

#65

Post by TheJurgen »

je42 wrote: post #58
lytefm wrote: post #56

Earlier quoted context omitted.

I'm also wondering about that. Abbott isn't known for making the raw CGM data easily available. Neither is Oura. It might be possible via Google fit/ Apple health or via nightscout for the CGM devices, but the latter would imply some legal trouble. Maybe OP can clarify some details of how the integration works in this product.

Yeah. However, if you have a libre2 you need a patched app and then nightscouts xdrip etc to get the data of the cgm into a db. Or you need bubble or miaomiao and again xdrip ;) Adding a description of the setup that the author used would make the article much more substantial than it is now.

I used the system I built with my team for real time health data tracking that includes data from a continuous glucose sensor, Apple Health data (sleep, activity, heart rate, etc), urinalysis feature within Basis for the majority of this. The only data that wasn’t acquired via Basis was the blood panel.

Re: Body on a 3-day fast: Real-time data with Basis

#67

Post by je42 »

TheJurgen wrote: post #65
je42 wrote: post #58

Earlier quoted context omitted.

Yeah. However, if you have a libre2 you need a patched app and then nightscouts xdrip etc to get the data of the cgm into a db. Or you need bubble or miaomiao and again xdrip ;) Adding a description of the setup that the author used would make the article much more substantial than it is now.

I used the system I built with my team for real time health data tracking that includes data from a continuous glucose sensor, Apple Health data (sleep, activity, heart rate, etc), urinalysis feature within Basis for the majority of this. The only data that wasn’t acquired via Basis was the blood panel.

so we were wondering which "continuous glucose sensor" and how you were able to extract the data from it.

Re: Body on a 3-day fast: Real-time data with Basis

#68

Post by hrjet »

hsuduebc2 wrote: post #54

I'm not biochemist but: 1) If you are not eating for some extended period of time, your body starts to have deficit of not only glucose but also proteins which are then accquired from your own muscles. E.g you are not losing only weight but muscles too. 2) There are various types of immune system cells and they all have different lifespan. If your body detects new pathogen it start's to produce various new immune sys…

For the first problem, you need to ensure that you exercise the muscles along with fasting, to nudge the body away from salvaging proteins from muscle tissue. (Not a bio chemist either, this is what I have read in most articles about intermittent fasting)

Re: Body on a 3-day fast: Real-time data with Basis

#70

Post by TheJurgen »

nsomaru wrote: post #34
TheJurgen wrote: post #17

Earlier quoted context omitted.

How about the American diet. A week on pizzas, burgers, sodas and donuts with real time data?

Yes and compare with a healthy diet. Control as many variables as possible (eating time, exercise time and duration, etc)

Ok will post this next
Post reply on HN