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Moderna is announcing three new vaccine programs

investors.modernatx.com

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Re: Moderna is announcing three new vaccine programs

#131

Post by nojito »

danfo wrote: post #78
throwarayes wrote: post #8

Very cool! Also I’d hope to see Lyme in the mix. It’s so pervasive and creates all kinds of weird dietary and nervous system issues.

>It’s so pervasive and creates all kinds of weird dietary and nervous system issues. I am not an expert, but I think it would be amiss to omit the Lyme disease controversy with these statements. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477530/ Lyme disease has a simple antibiotic treatment. The Lyme serology test has high false-positive rate. There might be many people who believe they have Lyme disease therefor…

If you’re not an expert why would you link a manuscript to stir up a thread?

CLD is real and even if it’s over diagnosed, it still doesn’t take away the many real diagnoses that exist and a vaccine would eliminate its potential permanently.

If you are posting in good faith...more recent studies are centered around making the findings in the European strain viable in the American one.

Re: Moderna is announcing three new vaccine programs

#132

Post by KraftKacke »

Erlich_Bachman wrote: post #93
Debug_Overload wrote: post #83

Earlier quoted context omitted.

Taking into account anything conspiracy nutjobs have to say about this stuff is an exercise in futility. They will not not find another wild excuse to declare conspiracy.

That might be the case, but it was just another way of saying that causing false positives on HIV tests is a huge issue for a vaccine. It should absolutely be prevented if possible, or at the very least adresssed somehow.

If the vaccine proves effective, you could do a test before and then vaccinate on negative knowing you test positive afterwards for a while.

It's very different to a false positive to _another pathogen. That leaves you blind, indeed.

Re: Moderna is announcing three new vaccine programs

#133

Post by lentil_soup »

vmception wrote: post #82
mikeyouse wrote: post #10

Earlier quoted context omitted.

Yeah I agree - so much of the original downlplaying of Covid was along the lines of "Well, the flu kills 50,000 people per year and we don't take extraordinary measures" which is an insane line of thought for multiple reasons but not least because we just write off 50,000+ people per year without much of a stink.

Now its moved to “but lockdowns have been going on so long that this is just normal deaths from everything else” and “thats not a covid death!” Not realizing that the flu also has those same counting errors or overlapping causes, leading everyone to begin clarifying “complications related to COVID-19” “Fortunately” we get to see how much further their mental gymnastics will go as the death count will begin greatly ex…

yeah, I've already started hearing the "but all the side effects from the lockdown are worse". Which of course dismisses all the non-death side-effects from covid.

Re: Moderna is announcing three new vaccine programs

#134

Post by OskarS »

henearkr wrote: post #121
miskin wrote: post #98

Earlier quoted context omitted.

But as the parent explained, many of these chronic Lyme patients may be just misdiagnosed. They believe they have Lyme, but the problem is some other disease.

If chronic Lyme illness is caused by lingering bacteria hidding in the body's tissues, the real way to eliminate any doubts about alternate causes is precisely to get a Lyme vaccine. Then, if the symptoms persist, we could easily deduce that the cause is other. Except that one thing... the chronic Lyme could very well caused by an autoimmune side-effect (this is among the most serious explanations), in which case I d…

There is no way to eliminate these doubts. If you made a magical cure that totally eliminated the bacteria that causes Lyme disease, then these patients would take it, and it would almost certainly not work (because "chronic Lyme" isn't a real syndrome, and these patients don't have this bacteria). However, that would not convince them, they'd just claim that the medical establishment has failed them yet again (or worse: they become anti-vaxxers). You can't treat fictitious diseases with real drugs.

Re: Moderna is announcing three new vaccine programs

#135

Post by MagnumOpus »

Bellamy wrote: post #85
cogman10 wrote: post #3

Really good news! Hopefully these get approved relatively quickly. I'm most excited about the seasonal flu vaccine. That could be a major game changer.

I can't understand people who wants to get vaccinated yearly for just a flu. Please make me understand. I mean it's just a flu and we have Netflix. As a Moderna shareholder I think that is stupid. As a healthy eater I think that is really stupid. Now I can only think I must be really stupid.

Same as Covid - getting a flu is a real ordeal for most people with days of fever and myalgia and if you pass it to your elderly relatives there's a chance it will kill them.

The vaccine is harmless both for you and your elderly relatives, so it is (a) smart to get it to avoid suffering yourself and (b) socially responsible to get it to lessen its spread to people it will kill.

Re: Moderna is announcing three new vaccine programs

#136

Post by KraftKacke »

unlikelymordant wrote: post #71
someperson wrote: post #58

Earlier quoted context omitted.

Any effective HIV vaccine would presumably cause false-positives to the HIV antibody tests. Recently an Australian COVID-19 vaccine candidate trial was halted due to participants developing antibodies to proteins in the vaccine that were taken from HIV genome, causing false-positive on a HIV test. [1] Such false-positives could easily be co-opted by anti-vaxxers especially in light of the the famous Soviet Union disi…

Wouldnt you want a hiv vaccine to create hiv antibodies? What other mechanism is there for the body to fight off a virus?

It's also very different if you shade the target disease tests, or of an unrelated pathogen. You'd only need to test positive before to rule out infection. It's not like your HIV status is known to anyone else, so it's a matter of information management, not risk inherently.

If we get an HIV vaccine it may also be therapeutic for HIV+ people. So far vaccine development wasn't getting anywhere because we're at loss with the nature of the virus. _If we find a persistent target, HIV may burn out in those infected and vaccinated. Seroconversion may then be something to look forward to.

Re: Moderna is announcing three new vaccine programs

#137

Post by henearkr »

OskarS wrote: post #134
henearkr wrote: post #121

Earlier quoted context omitted.

If chronic Lyme illness is caused by lingering bacteria hidding in the body's tissues, the real way to eliminate any doubts about alternate causes is precisely to get a Lyme vaccine. Then, if the symptoms persist, we could easily deduce that the cause is other. Except that one thing... the chronic Lyme could very well caused by an autoimmune side-effect (this is among the most serious explanations), in which case I d…

There is no way to eliminate these doubts. If you made a magical cure that totally eliminated the bacteria that causes Lyme disease, then these patients would take it, and it would almost certainly not work (because "chronic Lyme" isn't a real syndrome, and these patients don't have this bacteria). However, that would not convince them, they'd just claim that the medical establishment has failed them yet again (or wo…

People are not making up illness for the fun of it. Their ailments are very real and they have a cause.

Malingering exists, but the profile of the chronic Lyme patients you speak about is not at all the one of persons in need of being nursed by the society like babies...

Just imagine you go to the doctor and all you say is dismissed because he thinks you make it up? What a despair you would be in! Speaking of a closed logical system your physician would be in! The same kind as the ones making famous conspiracy theories.

"I had and I was not taken seriously for years" is such a recurrent theme that it is very concerning.

Just recently, the "long covid" was very much mocked by smug doctors. Imagine the distress of the patients.

You're wrong, these patients just failback on Lyme as a default and would be very pleased to discover the real causes of their ailments if it was found. To suppose that people are that much irrational and to generalize to this extent is... sorry but I am shocked.

In medicine, a golden rule is always assume your patient is honest in describing his problems.

Finally, contrary to what you said, the problem is not outside of the real world. Just as a link was proved between some tickborne pathogens and red meat allergy, you cannot exclude that one day a scientific team would prove that under some conditions the borreliosis provokes an autoimmune illness. And such a study would most likely point towards chemical markers to look for in blood and, at last, be able to diagnose it with certitude.

Re: Moderna is announcing three new vaccine programs

#138

Post by KraftKacke »

someperson wrote: post #69
KingMachiavelli wrote: post #68

Earlier quoted context omitted.

> Global mandatory inoculations using a safe and effective HIV vaccine that causes false-positive results on HIV tests would be a field day for anti-vaxxers and conspiracy theorists everywhere. There's no reason for it to be mandatory. It's not like COVID19 or the flu where it is often transmitted through casual contact. There is simply no reason to delay/halt an HIV vaccine for just causing an false positive on a te…

Definitely. I'm sure the then-flawed antibody tests would be retired and replaced with PCR tests.

"PCR" doesn't mean "more precise". It's limited to viral DNA/RNA presented. I don't think there is much HIV circulating, if you're not sero-converting. HIV isn't shedding constantly.

E.g. SARS2 PCR will often fail for blood samples.

Re: Moderna is announcing three new vaccine programs

#139

Post by KraftKacke »

KraftKacke wrote: post #136
unlikelymordant wrote: post #71

Earlier quoted context omitted.

Wouldnt you want a hiv vaccine to create hiv antibodies? What other mechanism is there for the body to fight off a virus?

It's also very different if you shade the target disease tests, or of an unrelated pathogen. You'd only need to test positive before to rule out infection. It's not like your HIV status is known to anyone else, so it's a matter of information management, not risk inherently. If we get an HIV vaccine it may also be therapeutic for HIV+ people. So far vaccine development wasn't getting anywhere because we're at loss wi…

This shitty mobile client can't do edits... Of course I mean test negative to rule out infection.

Re: Moderna is announcing three new vaccine programs

#140

Post by scrollaway »

gautamcgoel wrote: post #61

Any thoughts on whether MRNA is a good stock to buy? They seem to be killing it these days...

My thoughts are you shouldn't buy stocks if your strategy is asking strangers on the internet for tips.

If you want to gamble, just gamble, you don't need anyone's permission.

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