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Moderna is announcing three new vaccine programs

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11–20 of 236 posts

Re: Moderna is announcing three new vaccine programs

#11

Very cool! Also I’d hope to see Lyme in the mix. It’s so pervasive and creates all kinds of weird dietary and nervous system issues.

We already have a Lyme disease vaccine. However, the manufacturer refuses to sell it for human use due to PR threats from conspiracy theorists. Unfortunately, creating vaccines is only half the battle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/

Re: Moderna is announcing three new vaccine programs

#12
post #11

Very cool! Also I’d hope to see Lyme in the mix. It’s so pervasive and creates all kinds of weird dietary and nervous system issues.

We already have a Lyme disease vaccine. However, the manufacturer refuses to sell it for human use due to PR threats from conspiracy theorists. Unfortunately, creating vaccines is only half the battle. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/

It's very odd that dogs can get vaccinated for Lyme but not humans...

Re: Moderna is announcing three new vaccine programs

#13
post #9

(Caveat: amateur opinion based on mainstream broad understanding, not an actual scientist.) This is interesting, but so far a weak first step on flu. Each year experts stare at numbers and perhaps read some tea leaves to choose 4 strains to cover, often missing somewhat. The innovation I'd like to see: ignore the "choose 4" process, and instead aim to cover all known strains.

>amateur opinion based on mainstream broad understanding I don’t think experts are reading tea leaves and it’s pretty wild to claim that. There are literally billions of dollars at stake. To bring it bag to software, that’s like me claiming I think machine learning people are just using fancy excel formulas.

I mean... it's a lot of excel formulas, but still basically excel formulas!

Re: Moderna is announcing three new vaccine programs

#14
post #3

Really good news! Hopefully these get approved relatively quickly. I'm most excited about the seasonal flu vaccine. That could be a major game changer.

Yeah I agree - so much of the original downlplaying of Covid was along the lines of "Well, the flu kills 50,000 people per year and we don't take extraordinary measures" which is an insane line of thought for multiple reasons but not least because we just write off 50,000+ people per year without much of a stink.

Don't they already have flu vaccines. I thought the issue was that they changed so rapidly the vaccines can't keep up?

Re: Moderna is announcing three new vaccine programs

#15
post #5
post #2

Didn't Moderna already announce the seasonal flu vaccine programs on the research presentation day? Anyways, I really hope them to succeed, my mother didn't take the flu vaccine ,,because it's risky and not that useful anyways''. Moderna can make it much more efficient with less side effects, so I'm looking forward to it.

Vaccines are interesting, but I'm much more intrigued by what this may mean for future therapeutics if their methods work well moving forward.

There are a lot of companies (including mine) that have been working on personalised, target, combinatorial, interfering, etc. RNA therapeutics for quite some time. The success of RNA vaccines in the last year has really opened up the potential for pharma partnerships to test and develop these kinds of things. They have built out the infrastructure and there's a broad confidence and awareness of the basic concepts that was previously largely missing. Pharma just really loves proteins.

The next 5 years are going to be incredibly exciting - it has the potential to fundamentally change humanity's relationship with many kinds of disease.

Re: Moderna is announcing three new vaccine programs

#17
post #9

(Caveat: amateur opinion based on mainstream broad understanding, not an actual scientist.) This is interesting, but so far a weak first step on flu. Each year experts stare at numbers and perhaps read some tea leaves to choose 4 strains to cover, often missing somewhat. The innovation I'd like to see: ignore the "choose 4" process, and instead aim to cover all known strains.

>amateur opinion based on mainstream broad understanding I don’t think experts are reading tea leaves and it’s pretty wild to claim that. There are literally billions of dollars at stake. To bring it bag to software, that’s like me claiming I think machine learning people are just using fancy excel formulas.

> I think machine learning people are just using fancy excel formulas.

I mean... you can do it in excel it is just a lot... slower - you can do like anything in excel

https://youtu.be/s105jek4WUI

Re: Moderna is announcing three new vaccine programs

#18
post #14

Earlier quoted context omitted.

Yeah I agree - so much of the original downlplaying of Covid was along the lines of "Well, the flu kills 50,000 people per year and we don't take extraordinary measures" which is an insane line of thought for multiple reasons but not least because we just write off 50,000+ people per year without much of a stink.

Don't they already have flu vaccines. I thought the issue was that they changed so rapidly the vaccines can't keep up?

I think the idea is the mRNA vaccines are much faster to produce which makes it easier to keep up (but I could be wrong, this isn't my area of expertise).
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