> If the US has "lost" Asia as a partner, can it maintain its supply chain dependence?
The US hasn't lost Asia as a partner and it's not going to in an absolute manner. The US is losing its hegemony over Asia, which it has had since WW2. Those are two very different things.
Can the US keep Asia as a partner? Yes, mostly, through accepting that it will have to be less of a dominant hegemony in Asia and more of an at-the-table partner with the other nations in Asia that are not very willing to capitulate to China (Japan, Australia, New Zealand, South Korea, Vietnam, India, etc).
For example the US is intentionally flooding Vietnam with trade right now to build it up and working with them militarily to improve their positioning vs China. US imports from Vietnam are now equal to 23% of their economy; US imports from Vietnam will have increased by about 21% in 2020 (despite the pandemic). That will rapidly improve Vietnam in the same way it did China; in the next 20-30 years Vietnam will become a middle income nation comparable to Thailand or Malaysia. They're a quasi perma enemy of China, which is why they're so happy to be a strategic partner with the US (and why next to Israel the people of Vietnam like the US more than any other nation, accoring to Pew Research). The US can maintain supply chains with countries like Vietnam quite easily. The US will pull some of its dependency away from China and relocate it to other nations (whether Vietnam, India, Mexico, or similar).
The US can also simply increasingly accept its real context in Asia and cede more ground to China in exchange for maintaining trade with them (the EU is showing that it's happy to follow that path for example, it's plausible the US will partially capitulate in a similar manner). The US and China may continue to be quasi-enemies and competitors for global positioning, that trade with eachother, for a long time (and who knows what comes after Xi).
For their own self-defense, both South Korea and Japan should acquire nuclear weapons (if I were them); I wouldn't count on a receding US military superpower to come to the rescue, nor would I count on the thrashing-about-in-agony US population to take a self-interest in what China does in Asia (the growing stance in the US against foreign military adventurism will only increase by the year, as the US population demands an ever-increasing re-focus onto their well-being).