Live data from Hacker News

No one who got Moderna's vaccine in trial developed severe Covid-19

sciencemag.org

131–140 of 436 posts

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#131
post #56

Earlier quoted context omitted.

Honest question: would you wait if there was a pact to the effect that either everyone takes the vaccine, or no one does? Because obviously not getting vaccinated when everybody else does is almost always the best choice game-theoretically speaking; it doesn't really say anything on the vaccine (it may say more on the civic sense of the individual).

Let's see... it's a calculus of death vs potential long term adverse effect: P(death) I'd take the vaccine in a heartbeat, long term effects and all, if P(death) was 10% or higher.

[deleted]

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#132

note there is not a claim this vaccine prevents infection, only lessens symptoms, meaning you are still contagious. "We all expect an effective vaccine to prevent serious illness if infected. Three of the vaccine protocols—Moderna, Pfizer, and AstraZeneca—do not require that their vaccine prevent serious disease only that they prevent moderate symptoms which may be as mild as cough, or headache." "Prevention of infec…

That forbes article is quite weird. The trials have obviously been designed to find out if the vaccine helps prevent serious illness, as fast as possible. Questions like 'can vaccinated people still spread covid' are much harder to answer in a trial. Perhaps they'll look at that later.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#133

Earlier quoted context omitted.

A sunburn can change/damage your DNA.

And people take precautions to avoid it because skin cancer can result. Not sure that's the best counter example.

I'm not trying to argue that it's a "good" thing, simply that tons of things hack our DNA (there are even some studies that emotional trauma can have repercussions imprinted on our DNA) My major point is that DNA hacking/damage isn't always a life-ender. Even skin cancer is often removed without issue.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#134
post #48

Does anybody have a good link for a layman's overview of how mRNA vaccines work? Lot's of nervousness from people around this, and would love to be able to help quell some of that.

I'm interested in this as the only pushback I've heard has been from some Christian folks on YouTube claiming that we're no longer "human" if we hack or mix our DNA. I tend to look at it more like "right to repair". If I buy an iPhone, I should be able to hack it to my heart's content. I have no idea if that's the angle you're mentioning. I'd be really interested to hear the other potential dangers that others see.

I'm an atheist more or less and I agree with this sentiment. I'm not fond of transhumanism. But I don't think the mRNA vaccine process fits this description.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#135
post #19

FDA says Dec 17 meeting to discuss. This contradicts some earlier opinions that the reason the FDA was taking so long to review Pfizer (Dec 10 scheduled date) was that they were planning to review 2-3 candidates together. For context, scheduling the meeting to review the candidates is running at 5-10% of the development time for these vaccines. 20M vaccines represent about 1/3 the elderly population in the US, there…

Moderna didn't just have the vaccine in march. They had it mid-January 2020.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#136

Wonder what the trial exclusion criteria was...it’s not referenced in this article.

Can read all of them in their published protocol at https://www.modernatx.com/sites/default/files/mRNA-1273-P301... under section 5.2.

There is an additional question that opens the door to all sorts of hidden exclusions: Were study participants given medical advice prior to participation?

If I ask my doctor whether it is a "good idea" for me to participate in an investigational study like this, there are all number of reasons he may advise against. Those reasons form a defacto hidden list of exclusions. Would a doctor advise a patient with diabetes, high blood pressure, or any other chronic illness, to participate in such a study?

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#137
post #108

Earlier quoted context omitted.

>With this being the case, how does it even make sense for companies like Ticketmaster and Quantas to announce that they'll require their customers to be vaccinated? This is such a weird take imo. There is no need to vaccine non-risk people afaik. I thought the whole deal with covid is how mild it is for the general population but deadly for a subset of it.

We don't know a priori who will have very adverse reactions. Comorbities and old age increase your chances, but those are categorically not the only variables at play.

I'll admit I'm not super well informed on covid, so my opinion on this is weakly held, but isnt that an insanely small percentage of people?

I was under the impression that vaccine + immunity will just lead to herd immunity and the disease to go away on its own.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#138
post #83

Earlier quoted context omitted.

Relevant criteria for the question "does it it exclude old, fragile people with various common pre-existing conditions?" (not exhaustive, but indicative): Included: Pre-existing conditions are okay as long as they are in a stable condition (defined as no significant change in therapy etc for the 3 months before enrollment). Excluded: Immunosuppressive or immunodeficient state, asplenia, recurrent severe infections (H…

Immune suppressed/deficient patients are not good candidates for vaccines in the first place, since they would be unlikely to mount an effective immune response.

I forgot that part.

That's the reason why also young healthy people need to take the vaccine in order to stop the spread. It's a solidarity gesture.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#139
post #8

Yeah but imagine being dumb enough to get infected and very sick over the next month before you can get both shots next year. Because there are going to be thousands, maybe millions who do that in the USA alone for no good reason.

Dumb people like teachers, doctors, nurses, first responders, the infirm, grocery stockers? Dumb people that have to work to pay their rent, mortgage, put food on the table? I know there are a lot of idiot anti-maskers running around, but being dumb is not a prerequisite to catching covid. Not everyone has the luxury of working from home.

Most of the people catching it atm is from private social gatherings, AKA dumb behaviour.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#140
post #48

Does anybody have a good link for a layman's overview of how mRNA vaccines work? Lot's of nervousness from people around this, and would love to be able to help quell some of that.

Check out Dr. John Campbell's video titled "The next COVID year and vaccine function". http://www.youtube.com/watch?v=smm_ZvJqJk4&t=7m28s

We watched 100% of Dr. Campbell's videos for the first few months of the pandemic, and my wife still watches all of his stuff. Highly recommended.

He's strongly evidence and data based and steers clear of most anything that can reasonably be considered 'political'.

Post reply on HN