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No one who got Moderna's vaccine in trial developed severe Covid-19

sciencemag.org

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Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#71

Post by Antimateri4 »

NicoJuicy wrote: post #57
Antimateri4 wrote: post #6

Earlier quoted context omitted.

Yes i read some interesting article aswell regarding mRNA vaccines, but from my understanting mRNA vaccine aren't yet tested in humans right? Only animals or am i mistaken? EDIT: what my question is: is there another mRNA type vaccine out there fully developed (i'm not suggesting that they are bad!)? EDIT2: Guys, i will never ask question again in here. Begin downvoted for a genuine question.

You're probably being downvoted because this information is easily looked up. https://en.m.wikipedia.org/wiki/RNA_vaccine

Thanks! Yes I should have googled it myself as you mentioned. Silly me!

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#72

Post by itodd »

ed25519FUUU wrote: post #58
blhack wrote: post #48

Does anybody have a good link for a layman's overview of how mRNA vaccines work? Lot's of nervousness from people around this, and would love to be able to help quell some of that.

Edit: I do plan to get the vaccine, but as a software engineer I know beta versions usually have the most “bugs” — and I have the health privilege to be in the back of the line so I will!

It can't fundamentally change your own DNA. The mRNA codes for a stabilized version of the sars-cov2 spike protein. Your cells then use the mRNA to build that protein. Your immune system will then build up a response. It is a terrible idea to wait for a version 2 of this vaccine. Get vaccinated or this will not go away.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#73

Post by IgorPartola »

newdude116 wrote: post #49

Thats good but I would not be overly optimistic. Two question since I dont know much about mRNA vaccines 1. The mRNA has to express the target Protein for the Anitbodies. If injected, how does this happen? It has to go somehow into the cell to be translated? Or is the delivery vehicle the magic sauce? 2. What makes mRNA vaccines so special? What is the difference of injecting the expressed protein sequence directly?

I have no knowledge of this but if injecting spike proteins worked wouldn’t we just always do that? Seems like way easier than the rest of the delivery mechanism.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#75

Post by SpicyLemonZest »

dashundchen wrote: post #40
alfon wrote: post #16

Earlier quoted context omitted.

Not everyone has the privilege of working from home while they get their meal preps comfortably delivered to their doorstep.

No, but there have been plenty of people in the US gathering unnecessarily, not for essential work, but in large groups for Halloween parties and bars, with extended family and older relatives for Thanksgiving, and are likely to gather multiple times for Christmas once again. Now unsurprisingly the pandemic is out of control, hospitals in many regions are overcapacity and the overworked essential healthcare workers m…

Most Americans think gathering for Thanksgiving and Christmas is both altruistic and very important. Selfishly, I would have preferred to stay home and call in, but my mom didn't want to be alone on Thanksgiving so I drove down to be with her.

They're perhaps not necessary in the strict sense of the word, but health authorities have consistently said that very important gatherings are okay as long as you try to do them safely.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#76

Post by refurb »

officialjunk wrote: post #63

note there is not a claim this vaccine prevents infection, only lessens symptoms, meaning you are still contagious. "We all expect an effective vaccine to prevent serious illness if infected. Three of the vaccine protocols—Moderna, Pfizer, and AstraZeneca—do not require that their vaccine prevent serious disease only that they prevent moderate symptoms which may be as mild as cough, or headache." "Prevention of infec…

Right, but are there any vaccines out there that protect against disease but don’t prevent transmission? I thought that’s what herd immunity was all about.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#77

Post by newdude116 »

newdude116 wrote: post #49

Thats good but I would not be overly optimistic. Two question since I dont know much about mRNA vaccines 1. The mRNA has to express the target Protein for the Anitbodies. If injected, how does this happen? It has to go somehow into the cell to be translated? Or is the delivery vehicle the magic sauce? 2. What makes mRNA vaccines so special? What is the difference of injecting the expressed protein sequence directly?

Downvote because of two questions? Which dumbo did that?

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#78

Post by toast0 »

amurale wrote: post #56
lultimouomo wrote: post #45

Earlier quoted context omitted.

Honest question: would you wait if there was a pact to the effect that either everyone takes the vaccine, or no one does? Because obviously not getting vaccinated when everybody else does is almost always the best choice game-theoretically speaking; it doesn't really say anything on the vaccine (it may say more on the civic sense of the individual).

Let's see... it's a calculus of death vs potential long term adverse effect: P(death) I'd take the vaccine in a heartbeat, long term effects and all, if P(death) was 10% or higher.

If you get covid, there's a P(unknown) of long term harm as well.

It's an unknown vs an unknown. Novel virus, novel immunization (first mRNA or maybe first widespread modified adenovirus)

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#79

Post by newdude116 »

IgorPartola wrote: post #73
newdude116 wrote: post #49

Thats good but I would not be overly optimistic. Two question since I dont know much about mRNA vaccines 1. The mRNA has to express the target Protein for the Anitbodies. If injected, how does this happen? It has to go somehow into the cell to be translated? Or is the delivery vehicle the magic sauce? 2. What makes mRNA vaccines so special? What is the difference of injecting the expressed protein sequence directly?

I have no knowledge of this but if injecting spike proteins worked wouldn’t we just always do that? Seems like way easier than the rest of the delivery mechanism.

Yes, but it is still a legit question.

Re: No one who got Moderna's vaccine in trial developed severe Covid-19

#80

Post by jimbob45 »

CyberRabbi wrote: post #74

Why is AstraZeneca asking for exemption from liability claims stemming from their COVID-19 vaccine? https://uk.reuters.com/article/us-astrazeneca-results-vaccin...

> “This is a unique situation where we as a company simply cannot take the risk if in ... four years the vaccine is showing side effects,” Ruud Dobber, a member of Astra’s senior executive team, told Reuters.

Seems pretty straightforward to me. It’s an unproven method of vaccine creation and hasn’t been tested by anyone. I really can’t imagine this holding up in courts though.

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