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Covid vaccine: First ‘milestone’ vaccine offers 90% protection

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Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#793

Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?

The study is suspect end points. I cannot elaborate - too long. I will let the virologist PHDs weigh in here to take this point forward.

Tldr: i have a team in a top institution. There are gaps and the news is TGTBT.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#794
post #531

Earlier quoted context omitted.

I think we can eradicate it by contact tracing. With 90% efficiency it will be extremely tough for the virus to spread. For any new cases you simply test everyone in the vicinity of the infected person. But I don't think even that will be necessary. 90% efficiency reduces R so much, it will probably die out on its own. The real problem is mutations that are not covered by the vaccine. If it mutates as efficiently as…

This disease will never be "eradicated" and it is not helpful to use that word to discuss policy decisions. Sars CoV-2 has numerous animal reservoirs and an incredible transmission rate. It will never be gone from this Earth. We will get vaccines and we will come up with better treatments negating its effects, but this coronavirus is here to stay. It will be a fifth endemic human coronavirus.

There are a lot of coronaviruses and all tend to become mild overtime. In 1800, Influenza killed thousands of people daily. This endured through the 19th century,

Coronaviruses also have plagued humanity in the same way, for instance look up “bovine coronavirus”

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#795

Earlier quoted context omitted.

The RNA is read by human cells and the spike protein antigen is created by human cells; it’s not particularly viral RNA.

Okay pretty terrifying! How long does this random RNA stay in your cells?

? RNA is pretty ephemeral.

https://en.wikipedia.org/wiki/Translation_(biology)

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#796
post #372

Earlier quoted context omitted.

Contract tracing hasn't worked at scale anywhere. It's a nice idea conceptually, but the problem is psychological. People stop caring about tracing when 98% of all trace connections are false positives. If a person is infectious for a week and the r0 is around 1 then only 1 person of all the people they've been in contact with will actually contract the virus on average. The other 50+ people, assuming they can even b…

There's also participation on the contact side. In Western countries, surveys indicate we can't convince even half of people to install a contact tracing smartphone app. According to my state's department of health, practical experience indicates we can't convince even half of people to pick up the phone and respond to a contact tracing interview. > Covid19 would also be over if people with symptoms would just stay h…

Or, like me, your health department doesn't even bother to contact you. I had to do my own contact tracing when I tested positive.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#797
post #372

Earlier quoted context omitted.

I think we can eradicate it by contact tracing. With 90% efficiency it will be extremely tough for the virus to spread. For any new cases you simply test everyone in the vicinity of the infected person. But I don't think even that will be necessary. 90% efficiency reduces R so much, it will probably die out on its own. The real problem is mutations that are not covered by the vaccine. If it mutates as efficiently as…

Contract tracing hasn't worked at scale anywhere. It's a nice idea conceptually, but the problem is psychological. People stop caring about tracing when 98% of all trace connections are false positives. If a person is infectious for a week and the r0 is around 1 then only 1 person of all the people they've been in contact with will actually contract the virus on average. The other 50+ people, assuming they can even b…

Contact tracing is working extremely well here in New South Wales. But we have very low incidence of virus in the community, sufficient to get useful early warnings when DNA analysis picks up virus in the sewage system.

So once you're down to low levels of incidence in the community, given a robust well organised system, efficient contact tracing does prevent the virus from spreading in the community unchecked.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#798

Earlier quoted context omitted.

Who is dismissing it like this? Politicians, people, scientists?

Scientists and the media, thus the general population. I don’t doubt politicians will follow tomorrow.

Seems suspect. Do they not trust Pfizer and Oxford University? Seems the best minds in the world are on this problem, and they feel confident.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#799

Earlier quoted context omitted.

The latest data (preprint, not peer reviewed etc etc) mention memory B and T cells up to 8 months after recovery from the illness. This means that an immunity of one year is probably likely. This would be probably enough to quench the spread, but not to eradicate the virus.

I think we can eradicate it by contact tracing. With 90% efficiency it will be extremely tough for the virus to spread. For any new cases you simply test everyone in the vicinity of the infected person. But I don't think even that will be necessary. 90% efficiency reduces R so much, it will probably die out on its own. The real problem is mutations that are not covered by the vaccine. If it mutates as efficiently as…

> With 90% efficiency it will be extremely tough for the virus to spread

Aren't you assuming 100% coverage at 90% effectiveness?

What if it's - say - only 50% coverage, at 90% effectiveness. That's not looking so good.

I'm still trying to understand why an otherwise young and healthy person would want to get take one, or more likely multiple, shots of a C19 vaccine, given the risk from C19 is so low. What's the benefit to them?

In HN-speak: how well does a C19 vaccine deployment scale?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#800

Earlier quoted context omitted.

Yet another reason to move to a plant-based lifestyle. Covid came from some folks in China using exotic animals for some purpose. Now a new variant seems inevitable from animal populations. Is it worth the burgers and coats?

You have to love the morons who downvoted you when it's painfully obvious that eating meat is the cause of so much health and environmental issues on the planet. For most people here, it's not even that big a deal to switch to a plant-based diet or mostly plant-based diet. Better to adapt now rather when the double or triple digit taxes start coming for our meat-eating asses.

The true origin isn’t known. Maybe escaped from a lab, we don't know yet.
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