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Covid vaccine: First ‘milestone’ vaccine offers 90% protection

bbc.co.uk

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Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#711

Post by hcknwscommenter »

f38zf5vdt wrote: post #461
EamonnMR wrote: post #424

Earlier quoted context omitted.

Flu has a unique capability to recombine that allows it to mutate more readily than other viruses. Hoping that the more simple coronavirus will be less fortunate. https://en.m.wikipedia.org/wiki/Antigenic_shift

Ability to recombine is not unique to the flu. SARS-CoV-2 is suspected to have been formed through a recombination event in vivo. [1] Mutation rates can also be manipulated through selective pressure e.g. vaccine-based herd immunity. For example, a vaccine-resistant polio virus has recently emerged. [2] [1] https://advances.sciencemag.org/content/6/27/eabb9153 [2] https://www.sciencedaily.com/releases/2014/11/1411041…

The comment you respond to states "more readily." This is undoubtedly true. Influenza virus is designed to recombine at every single replication cycle. Coronaviruses as a whole do not do that. We have a lot of data on coronavirus mutation rates and they are dramatically lower (1000x) than influenza. The point is not that mutation/recombination can't happen (it can and will happen), it is just that this mutation/recombination is relatively rare and we will not get the standard twice-yearly seasonal flu effect where we have to tweak the vaccine every year.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#712

Post by MichaelMoser123 »

jakozaur wrote: post #214

Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?

For how long do the vaccines remain effective? I couldn't get any predictions on that.

Some links that might be relevant:

https://edition.cnn.com/2020/10/27/health/russia-coronavirus... Moderna vaccine requires storage at -20 °C Sputnik V at -18 °C; so that would be easier to handle.

https://www.ndtv.com/world-news/after-pfizer-russia-says-its... 90% effectiveness says the Russian vaccine Sputnik V

https://www.globaltimes.cn/content/1206008.shtml "No infections among 56,000 people who traveled abroad after receiving Sinopharm-developed COVID-19 vaccine"

https://www.jpost.com/health-science/hadassah-bringing-15-mi... Israel is bying Russian vaccine shots, the head of Hadassah hospital says there is quite a lot of power politics involved in the discourse (Hadassah is one of the major hospitals in Israel)

https://www.berliner-zeitung.de/wirtschaft-verantwortung/cor... (in German) for the EU some producers of COVID vaccines got an exemption clause for liabilities, they say because of very tight development schedules (says an unnamed speaker of the European Comission)

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#713

Post by adventured »

chasd00 wrote: post #470
aphextron wrote: post #286

Earlier quoted context omitted.

>I'm feeling a deep-seated wave of relief that I never thought possible. Like waking up from a year-long nightmare. Thank God. Moderna is also only weeks behind Pfizer/Biontech here with a very similar technology and manufacturing capability of hundreds of millions of doses. We'll be seeing the first EUA's by December, and shots in the arm before the end of the year. Pretty incredible that we can just science our way…

thank god Biden was elected, otherwise this news would have been thrown in the trash.

[flagged]

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#714

Post by hcknwscommenter »

m4eta wrote: post #611
try-perforate wrote: post #449

Earlier quoted context omitted.

This vaccine is against the entire spike glycoprotein. Some in production vaccines are only against the RBD (the protein that actually latches onto ACE2). There are variants out there that have been shown to escape RBD antibodies. However, since this vaccine encodes the entire spike, there are other areas that antibodies can bind to. They stated in their press release that the vaccine elicits a Th1, CD4+, and CD8+ T-…

Can you tell me why I shouldn't worry that vaccines which are made to flood the body with fake ACE2 proteins won't affect blood pressure, body water and sodium content? What happens to all the angiotensin II that connects to dummy ACE2 connectors?

>vaccines which are made to flood the body with fake ACE2 proteins

There is no such thing as a vaccine that floods the body with fake ACE2 proteins.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#715

Post by RobertDeNiro »

MichaelMoser123 wrote: post #712
jakozaur wrote: post #214

Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?

For how long do the vaccines remain effective? I couldn't get any predictions on that. Some links that might be relevant: https://edition.cnn.com/2020/10/27/health/russia-coronavirus... Moderna vaccine requires storage at -20 °C Sputnik V at -18 °C; so that would be easier to handle. https://www.ndtv.com/world-news/after-pfizer-russia-says-its... 90% effectiveness says the Russian vaccine Sputnik V https://www.global…

These are the most difficult numbers to have because the vaccine and trials are still only a few months old.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#716

Post by RobertDeNiro »

thehappypm wrote: post #616
snarf21 wrote: post #430

Earlier quoted context omitted.

This is good news but I'm worried about the mutation already showing up in minks in Denmark. Minks apparently have a near identical respiratory system. https://www.nbcnews.com/news/world/denmark-plans-kill-15-mil...

Yet another reason to move to a plant-based lifestyle. Covid came from some folks in China using exotic animals for some purpose. Now a new variant seems inevitable from animal populations. Is it worth the burgers and coats?

You're being downvoted for no good reason. Mass farming is what brought us here. This will keep happening, unless we change our behavior.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#718

Post by hinkley »

benlumen wrote: post #149

I'm feeling a deep-seated wave of relief that I never thought possible. Like waking up from a year-long nightmare. Thank God.

I'm glad we are going to have a vaccine, but I'm not so happy about 90%

I have built up in my head the idea of all the things I'm going to do 'once I get vaccinated', but at 90% that gets pushed off to "once most people get vaccinated". If it were by myself, I might push my luck. But I want to do those things with friends, or family. .9^n is pretty shitty odds once n gets to around 5.

There's a sort of rhetoric that's pointed out by 'Thinking, Fast and Slow' as a warning sign for agendas, and I've seen a bunch of them used by both sides this election cycle. But at the same time one of the defenses against these rhetorical devices is reframing: rephrase the bargain from another context and see if you'd still accept it. They don't seem to reconcile that in public discourse this reframing happens in public.

"If I go out for steak, I'm probably okay at 90%," versus, "If we have our family reunion at Disney World, there's a 50% chance we're all going to be attending a funeral in a month, even if everybody got the vaccine." You could call the latter shrill, sure, but "there's a 50% chance everything will work out fine," is self-deception. You're trying really hard not to look at all of the potential, statistically significant outcomes.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#719

Post by tinus_hn »

mrozbarry wrote: post #618
tinus_hn wrote: post #582

Earlier quoted context omitted.

Well that settles it then. We’ll just wait for a few more years to see what the long term side effects are.

I know you say that in mockery, but I'd rather be in isolation for longer and have a better idea what the long term of this looks like. Most other vaccines have the same process.

Feel free to do so, as long as you don’t expect someone else to pay the price.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#720

Post by gilbetron »

m4eta wrote: post #611
try-perforate wrote: post #449

Earlier quoted context omitted.

This vaccine is against the entire spike glycoprotein. Some in production vaccines are only against the RBD (the protein that actually latches onto ACE2). There are variants out there that have been shown to escape RBD antibodies. However, since this vaccine encodes the entire spike, there are other areas that antibodies can bind to. They stated in their press release that the vaccine elicits a Th1, CD4+, and CD8+ T-…

Can you tell me why I shouldn't worry that vaccines which are made to flood the body with fake ACE2 proteins won't affect blood pressure, body water and sodium content? What happens to all the angiotensin II that connects to dummy ACE2 connectors?

That's a therapy being worked on, not a vaccine.
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