Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Covid vaccine: First ‘milestone’ vaccine offers 90% protection

bbc.co.uk

Post reply on HN
Print view View original

611–620 of 1001 posts

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#611

Post by m4eta »

try-perforate wrote: post #449
lbeltrame wrote: post #271

Earlier quoted context omitted.

The latest data (preprint, not peer reviewed etc etc) mention memory B and T cells up to 8 months after recovery from the illness. This means that an immunity of one year is probably likely. This would be probably enough to quench the spread, but not to eradicate the virus.

This vaccine is against the entire spike glycoprotein. Some in production vaccines are only against the RBD (the protein that actually latches onto ACE2). There are variants out there that have been shown to escape RBD antibodies. However, since this vaccine encodes the entire spike, there are other areas that antibodies can bind to. They stated in their press release that the vaccine elicits a Th1, CD4+, and CD8+ T-…

Can you tell me why I shouldn't worry that vaccines which are made to flood the body with fake ACE2 proteins won't affect blood pressure, body water and sodium content? What happens to all the angiotensin II that connects to dummy ACE2 connectors?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#612

Post by aphextron »

adamjb wrote: post #418
TulliusCicero wrote: post #385

Earlier quoted context omitted.

Have there historically been issues with vaccines causing problems for the long term that didn't show initially? I've never heard of such a thing, but then again I have only a surface understanding of vaccines.

The 1976 Swine Flu outbreak and subsequent bungled vaccination campaign comes to mind

>The 1976 Swine Flu outbreak and subsequent bungled vaccination campaign comes to mind

Given that viral genome sequencing didn't even exist in 1976, I don't think it's a meaningful comparison.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#613

Post by grecy »

InterMilan wrote: post #592
thatwasunusual wrote: post #479

Earlier quoted context omitted.

> Thank God. God also gave us this virus, if we stick to the religious logic.

I thought it was bush meat. So human decided to eat something that they shouldn't. Geniuinly asking.

Did god put warning labels on things we should and shouldn't eat?

How do I use God's wisdom to decide if if a certain pig is "safe" to eat or not?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#614

Post by this_user »

DanBC wrote: post #437
jakozaur wrote: post #214

Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?

Also not so good: this is a corporate press release. The data will come later.

The results came from the independent data safety and monitoring board that is analysing the trial results on PFE/BNTX's behalf. PFE/BNTX themselves don't currently have access to more data. But there is no reason to suspect that these results are not accurate.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#615

Post by jccooper »

TomVDB wrote: post #498
gizmo wrote: post #372

Earlier quoted context omitted.

Contract tracing hasn't worked at scale anywhere. It's a nice idea conceptually, but the problem is psychological. People stop caring about tracing when 98% of all trace connections are false positives. If a person is infectious for a week and the r0 is around 1 then only 1 person of all the people they've been in contact with will actually contract the virus on average. The other 50+ people, assuming they can even b…

“Anywhere” as in “the western world”? Because contact tracing seems to work very well at scale in Asia.

Did it work at scale, or did it work because it was employed early enough (along with other strict measures) that it didn't have to scale much? The latter is my understanding.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#616

Post by thehappypm »

snarf21 wrote: post #430
jakozaur wrote: post #214

Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?

This is good news but I'm worried about the mutation already showing up in minks in Denmark. Minks apparently have a near identical respiratory system. https://www.nbcnews.com/news/world/denmark-plans-kill-15-mil...

Yet another reason to move to a plant-based lifestyle. Covid came from some folks in China using exotic animals for some purpose. Now a new variant seems inevitable from animal populations. Is it worth the burgers and coats?

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#617

Post by DCKing »

jakozaur wrote: post #214

Good: + ~90% of individuals achieve immunity. + no significant side-effects. Not so good: - two doses needed, 3 weeks apart, immunity after one month from first dose. Slow rollout. - -80C storage and transport needed. Challenging, but doable in developed countries, but still may slow down mass rollout. Not feasible in many developing countries. I still wonder about long-term immunity. Anyone can share any insight?

The complexity of the distribution of such a vaccine on such a large scale will be a major bottleneck in a return to a society without imposed pandemic measures. A much less sexy and more human bottleneck, which permits of far more classes of failure of getting the virus to people well. The distribution is important work which we will see being the subject of much criticism. I hope everybody can keep their expectations in check. Getting working vaccines is incredibly important, but this is just the first step. There are no easy fixes - we'll be in this situation for the foreseeable future.

Re: Covid vaccine: First ‘milestone’ vaccine offers 90% protection

#618

Post by mrozbarry »

tinus_hn wrote: post #582
mrozbarry wrote: post #567

No significant side effects so far tested. I'm always curious what the long term side effects will be, and we won't know that for years.

Well that settles it then. We’ll just wait for a few more years to see what the long term side effects are.

I know you say that in mockery, but I'd rather be in isolation for longer and have a better idea what the long term of this looks like. Most other vaccines have the same process.
Post reply on HN