41–50 of 201 posts
I did not expect to see Tim Ferriss's name in an article like this. Interesting.
Earlier quoted context omitted.
What kind of placebo could you use to stand in for a treatment that normally has immediate and obvious side effects like this one?
You can just use the standard sugar pill placebo. But of course make sure the placebo group get the same treatment of lying on a couch and listening to music with their eyes closed. I am sure the psychedelic effects of shrooms would increase the placebo effect greatly, so sugar pill placebo might not correctly show the placebo effect, but it is a start.
As hopeful as I am for unconventional drugs to have more medicinal uses, is it unreasonable for me to think there's no good medicinal depression cure? Is it unfounded to think depression generally has its roots in being disconnected from other people/society? I've felt depressed before, but I've probably never had it as bad as many people. But generally I've felt depressed when my life felt too narrow. When I've felt…
As hopeful as I am for unconventional drugs to have more medicinal uses, is it unreasonable for me to think there's no good medicinal depression cure? Is it unfounded to think depression generally has its roots in being disconnected from other people/society? I've felt depressed before, but I've probably never had it as bad as many people. But generally I've felt depressed when my life felt too narrow. When I've felt…
I imagine this drug can uncover the problem and help the person solve it.
As hopeful as I am for unconventional drugs to have more medicinal uses, is it unreasonable for me to think there's no good medicinal depression cure? Is it unfounded to think depression generally has its roots in being disconnected from other people/society? I've felt depressed before, but I've probably never had it as bad as many people. But generally I've felt depressed when my life felt too narrow. When I've felt…
Earlier quoted context omitted.
Did you find a doctor, or otherwise? I have severe chronic pain, and resulting depression that affects my pain perception, and am interested in trying this route.
In Arizona, with a chronic pain doctor, I was able to get pure ketamine liquid infusion via IV for 3-4 hours, while I listened to music. Felt like rebirth. My spinal pain was significantly decreased for the next few weeks, and my mood was ecstatic. Like the mushrooms though, it is short-lived. The doctor liked prescribing it because it is an NMDA agonist and decreased my opioid tolerance quite a bit, also helps with…
I've had a very bad experience w/anesthesia so am always nervous while dealing with anything of that nature. Wonder if that predisposes me to a bad trip.
Not sure that would be worth it for just 2 weeks of relief.
Also not sure I'd be able to find any such doctor near me. Probably health care providers are much more open minded out West than it is here.
"Two psilocybin sessions (session 1: 20 mg/70 kg; session 2: 30 mg/70 kg) were given (administered in opaque gelatin capsules with approximately 100 mL of water) in the context of supportive psychotherapy (approximately 11 hours)." Curious if that's enough for the patients to have a psychedelic experience.
As hopeful as I am for unconventional drugs to have more medicinal uses, is it unreasonable for me to think there's no good medicinal depression cure? Is it unfounded to think depression generally has its roots in being disconnected from other people/society? I've felt depressed before, but I've probably never had it as bad as many people. But generally I've felt depressed when my life felt too narrow. When I've felt…
>New study finds psilocybin greatly and quickly relieves depression Nope, it doesn't. The study wasn't placebo controlled. The placebo effect will have a large effect in a study like this, so we have no idea what effect the psilocybin had.
How about we read the paper first before jumping to conclusions. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/... Findings In this randomized clinical trial of 24 participants with major depressive disorder, participants who received immediate psilocybin-assisted therapy compared with delayed treatment showed improvement in blinded clinician rater–assessed depression severity and in self-reported secon…
As hopeful as I am for unconventional drugs to have more medicinal uses, is it unreasonable for me to think there's no good medicinal depression cure? Is it unfounded to think depression generally has its roots in being disconnected from other people/society? I've felt depressed before, but I've probably never had it as bad as many people. But generally I've felt depressed when my life felt too narrow. When I've felt…
Maybe the easiest way to think of it is an electrochemical circumstance in the brain. This circumstance could come about as a result of external stimuli (or lack thereof), or through some imbalance or other more internal issue. I think the technical terms are something like situational depression vs clinical depression.
Even with situational depression, a fresh perspective can often give people the bit of confidence and hope that they need to proactively break depressive cycles.