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New study finds psilocybin greatly and quickly relieves depression

psychnewsdaily.com

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Re: New study finds psilocybin greatly and quickly relieves depression

#21
post #11

Earlier quoted context omitted.

Works for mine. I need to take a heroic dose (5 gr) and then it lasts about 3 months before I need to again.

Isn't that what the parent post said? Works temporarily but doesn't last?

> Works temporarily but doesn't last?

I'd have assumed it meant a tolerance would kick in after a few rounds.

1 reset day out of every 100 does sound achievable/possible even with clinical administration, but needing it every 3 days wouldn't be.

Re: New study finds psilocybin greatly and quickly relieves depression

#22

Earlier quoted context omitted.

Just passed in Oregon: Oregon Measure 109. Legalize Psilocybin Permits licensed service providers to administer psilocybin-producing mushroom and fungi products to individuals 21 years of age or older.

Here's my issue with that: Who are the service providers of the treatment and what training have they taken to do so? There is some available through folks who did original research (eg: John Hopkins) and now do talk and demo circuits but otherwise it's all largely undefined. I'm paranoid of what this might lead to without strong community standards and ethics. A good first step, but lets hope it doesn't ruin it for…

So previously they were illegal and you bought dried mushrooms from some guy in a pool hall (maybe I'm dating myself). Its hard to imagine that legalizing them is a step back. People automatically see legalization as an excuse for more bureaucracy and regulation - how about starting with the premise that the world didnt end while people bought it illegally, and ease in a minimal way to ensure safety and quality, which must be well understood for all the other foods and natural products already sold, instead of doing the regulatory power grab of "oh we need a whole new framework!"

Re: New study finds psilocybin greatly and quickly relieves depression

#23

>New study finds psilocybin greatly and quickly relieves depression Nope, it doesn't. The study wasn't placebo controlled. The placebo effect will have a large effect in a study like this, so we have no idea what effect the psilocybin had.

What kind of placebo could you use to stand in for a treatment that normally has immediate and obvious side effects like this one?

Re: New study finds psilocybin greatly and quickly relieves depression

#24

>New study finds psilocybin greatly and quickly relieves depression Nope, it doesn't. The study wasn't placebo controlled. The placebo effect will have a large effect in a study like this, so we have no idea what effect the psilocybin had.

Yeah, I'm going to want the same psychotherapy given to a group given psilocybin, a group given traditional antidepressants, and a group given placebo (with the psychotherapist blinded to administered drug).

Re: New study finds psilocybin greatly and quickly relieves depression

#26
post #11

Earlier quoted context omitted.

Works for mine. I need to take a heroic dose (5 gr) and then it lasts about 3 months before I need to again.

Isn't that what the parent post said? Works temporarily but doesn't last?

Considering there's no evidence it's toxic and you can do it every month because that's how long it takes for your tolerance to wear off, 3 months is a lot of time.

Consider normal SSRIs where you feel like crap for a month, try N more (which could mean many more months) until you find one that suits you, then have side-effects, then try to get off them so that's another couple of months of misery.

That's countless doses, money, time spent in misery vs one day of mushrooms every 3 months.

Normal psych meds are to be avoided at all costs and only be used if absolutely necessary, after you have tried everything else; atleast in my opinion.

Re: New study finds psilocybin greatly and quickly relieves depression

#27

>New study finds psilocybin greatly and quickly relieves depression Nope, it doesn't. The study wasn't placebo controlled. The placebo effect will have a large effect in a study like this, so we have no idea what effect the psilocybin had.

How about we read the paper first before jumping to conclusions.

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...

Findings In this randomized clinical trial of 24 participants with major depressive disorder, participants who received immediate psilocybin-assisted therapy compared with delayed treatment showed improvement in blinded clinician rater–assessed depression severity and in self-reported secondary outcomes through the 1-month follow-up.

Meaning This randomized clinical trial found that psilocybin-assisted therapy was efficacious in producing large, rapid, and sustained antidepressant effects in patients with major depressive disorder.

Re: New study finds psilocybin greatly and quickly relieves depression

#29
post #26
post #11

Earlier quoted context omitted.

Isn't that what the parent post said? Works temporarily but doesn't last?

Considering there's no evidence it's toxic and you can do it every month because that's how long it takes for your tolerance to wear off, 3 months is a lot of time. Consider normal SSRIs where you feel like crap for a month, try N more (which could mean many more months) until you find one that suits you, then have side-effects, then try to get off them so that's another couple of months of misery. That's countless d…

I think the primary reason for “normal” psych meds is they’ve been tested well for harm reduction first and foremost. That’s why the front line SSRIs are front line, they have less chance of a negative effect. Downside is it’s mild, and there’s plenty of evidence that the “low seratonin” theory of depression doesn’t apply to many.

Psilocybin is an intense acute experience. People can have negative effects. I hope we do studies to find how to use it most safely, or isolate the beneficial aspect without the intoxicating effects.

Re: New study finds psilocybin greatly and quickly relieves depression

#30
We have to be careful to prescribe these psychotropic substances willy-nilly to the general population. Cannabis has always initially worked well for me, but 1-2 months into using it, it causes schizophrenic/manic episodes. I cannot touch it anymore because of the possible permanent damage it could do.
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