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Intermittent fasting from dawn to sunset induces anticancer response

pubmed.ncbi.nlm.nih.gov

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Re: Intermittent fasting from dawn to sunset induces anticancer response

#51

Post by fredophile »

mikenew wrote: post #9

> Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure Would really like to see this compared to another group with a similar level of calorie restriction but without the intermittent fasting. The question with intermittent fasting is really just "is it better than plain old calorie restriction". Seems like there's some evidence that points to "yes" and some…

I don't have any studies handy but here's what I remember from looking into this. IF does not lead to more weight loss than other diets when you match calories. At least some forms of IF also have lower adherence than simple caloric restriction.

My own anecdata suggests that I have better adherence to IF than regular caloric restriction. YMMV. The diet that helps you lose the most weight will be the one you follow closest.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#52

Post by voisin »

mrfusion wrote: post #44
voisin wrote: post #17

Earlier quoted context omitted.

From what I understand, autophagy doesn’t start until 18 hours and doesn’t peak until 72 hours.

I’ve been looking for a good source but haven’t found one. Has it not been studied in humans yet?

I think I heard it on the FoundMyFitness podcast which has excellent discussions about fasting science. I think it may have been the last interview with Valter Longo. I’ll see if I can dig it up, but their website would be a good starting point.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#54

Post by aaaxyz »

skynetv2 wrote: post #27

Can someone post a TL;DR

>[...] we conducted a pilot study in 14 subjects with metabolic syndrome who fasted (no eating or drinking) from dawn to sunset for more than 14 h daily for four consecutive weeks. [...] Further studies are needed to test the intermittent fasting from dawn to sunset in the prevention and treatment of metabolic syndrome-induced cancers.

That's the gist of it.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#55

Post by irjustin »

mikenew wrote: post #9

> Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure Would really like to see this compared to another group with a similar level of calorie restriction but without the intermittent fasting. The question with intermittent fasting is really just "is it better than plain old calorie restriction". Seems like there's some evidence that points to "yes" and some…

From a pure scientific underlying root method - I agree with you.

The problem I see is if this question is the only one, the immediate second question becomes - does Intermittent Fasting produce the same results? requiring an additional study.

From a practical implementation, this research is better suited to everyday life. Intermittent Fasting as a system is way easier to implement at scale than calorie counting.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#56

Post by optymizer »

Anecdata:

I have followed IF with a 1100 calorie deficit per day by only eating 1200 calories at dinner for 3 months. This translated to more than 1kg weight loss per week, pretty reliably. Overall I lost 17kg. I adjusted the TDEE and calorie values as needed to maintain the weight loss speed.

The weight loss was extremely fast, but so was the rate at which I lost lean mass. This makes sense, as I didn't exercise much, aside from occasional long walks / 1 mile run. According to this study [0], exercising should maintain lean muscle mass.

My personal observations are in line with the studies I have read about IF.

Some other observations I have made:

* The rate at which I gained 75% of the weight back was stunning to me. It was as fast as I lost it.

* My partner does not feel well when fasting, so IF doesn't work for everyone. I think it worked well for me. I did supplement with vitamins to account for the decreased amount of food intake.

* I noticed that whenever I had alcohol, while still adhering to the daily calorie limit, my weight would not go down until about 3 days have passed. I had assumed alcohol would only contribute its caloric energy, but, sure enough, every time I had a beer, I could see in the weight graph a bump that lasted for about 3 days, then the weight would suddenly jump down to where I was expecting it to be, based on the weight loss slope.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468742/

Re: Intermittent fasting from dawn to sunset induces anticancer response

#57

Post by tracker1 »

fredophile wrote: post #51
mikenew wrote: post #9

> Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure Would really like to see this compared to another group with a similar level of calorie restriction but without the intermittent fasting. The question with intermittent fasting is really just "is it better than plain old calorie restriction". Seems like there's some evidence that points to "yes" and some…

I don't have any studies handy but here's what I remember from looking into this. IF does not lead to more weight loss than other diets when you match calories. At least some forms of IF also have lower adherence than simple caloric restriction. My own anecdata suggests that I have better adherence to IF than regular caloric restriction. YMMV. The diet that helps you lose the most weight will be the one you follow cl…

Can only speak anecdotally.. but I find it relatively easy to stick to one or two meals a day over trying to do smaller/frequent meals. Same goes for avoiding carbs (keto macros). When I eat more frequently or start adding starchy foods, I'm ravenous the next couple days.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#58

Post by tracker1 »

voisin wrote: post #17
ravenstine wrote: post #15

Earlier quoted context omitted.

My suspicion is that you would see similar improvement with things like waist circumference, BMI, blood pressure, at least initially, but that the difference with intermittent fasting is that it introduces enough of a "fasted state" that the body is able to perform repair and autophagy of senescent cells that would occur much less in a constantly fed state. (something about telomerase, but I probably shouldn't mentio…

From what I understand, autophagy doesn’t start until 18 hours and doesn’t peak until 72 hours.

Depends on what you're eating... if you're on a keto (fast mimicking) macro level intake, you'll reach autophagy a bit faster. Heavy exercise/resistance/lifting can also help speed this up, which can also lend to timing of exercise and food intake.
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