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Intermittent fasting from dawn to sunset induces anticancer response

pubmed.ncbi.nlm.nih.gov

21–30 of 388 posts

Re: Intermittent fasting from dawn to sunset induces anticancer response

#21
post #2

Welcome to Ramadan!

Good point. Do practicing Muslims have lower cancer rates?

Nothing stand-out from https://ourworldindata.org/cancer that would indicate that.

Alcohol would also be a factor in play as that would increase the risk of some cancers, so the lack of you would of thought also be a factor with that lifestyle.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#22
post #4

Earlier quoted context omitted.

They're only fasting for a month out of the year.

The duration in the article is 4 months. The real issue is small sample size. (14 people)

Also, not just 14 people, but 14 people with a metabolic disorder.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#23
post #9

> Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure Would really like to see this compared to another group with a similar level of calorie restriction but without the intermittent fasting. The question with intermittent fasting is really just "is it better than plain old calorie restriction". Seems like there's some evidence that points to "yes" and some…

We’re working on this. Harder than it seems.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#24
post #17

Earlier quoted context omitted.

My suspicion is that you would see similar improvement with things like waist circumference, BMI, blood pressure, at least initially, but that the difference with intermittent fasting is that it introduces enough of a "fasted state" that the body is able to perform repair and autophagy of senescent cells that would occur much less in a constantly fed state. (something about telomerase, but I probably shouldn't mentio…

From what I understand, autophagy doesn’t start until 18 hours and doesn’t peak until 72 hours.

Autophagy is always active, the real question is how that activity changes during fasting. The number of 18 hours is fairly arbitrary, as even after a few hours of fasting autophagy increases.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#25
post #9

> Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure Would really like to see this compared to another group with a similar level of calorie restriction but without the intermittent fasting. The question with intermittent fasting is really just "is it better than plain old calorie restriction". Seems like there's some evidence that points to "yes" and some…

True. However, even if intermittent fasting is no more effective than calorie restriction, from a human behavior perspective, it seems to be an easier way for many people to achieve their calorie goals than just "eating less".

Re: Intermittent fasting from dawn to sunset induces anticancer response

#26
post #17

Earlier quoted context omitted.

My suspicion is that you would see similar improvement with things like waist circumference, BMI, blood pressure, at least initially, but that the difference with intermittent fasting is that it introduces enough of a "fasted state" that the body is able to perform repair and autophagy of senescent cells that would occur much less in a constantly fed state. (something about telomerase, but I probably shouldn't mentio…

From what I understand, autophagy doesn’t start until 18 hours and doesn’t peak until 72 hours.

Autophagy is not a binary thing. Every body does autophagy all the time, it's the intensity/volume that increases in longer fasts.

Re: Intermittent fasting from dawn to sunset induces anticancer response

#29
post #23
post #9

> Subjects had a significant reduction in body mass index, waist circumference, and improvement in blood pressure Would really like to see this compared to another group with a similar level of calorie restriction but without the intermittent fasting. The question with intermittent fasting is really just "is it better than plain old calorie restriction". Seems like there's some evidence that points to "yes" and some…

We’re working on this. Harder than it seems.

By "we", you mean https://zerofasting.com/ ? Seems like a nice app!

Re: Intermittent fasting from dawn to sunset induces anticancer response

#30
post #17

Earlier quoted context omitted.

My suspicion is that you would see similar improvement with things like waist circumference, BMI, blood pressure, at least initially, but that the difference with intermittent fasting is that it introduces enough of a "fasted state" that the body is able to perform repair and autophagy of senescent cells that would occur much less in a constantly fed state. (something about telomerase, but I probably shouldn't mentio…

From what I understand, autophagy doesn’t start until 18 hours and doesn’t peak until 72 hours.

I've never heard of that 18 hour rule. It's funny because I've read a lot about fasting, but this is news to me, and it seems like this is reported from multiple sources. But I can't seem to find any authoritative references.
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