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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#641

Post by maxehmookau »

aphextron wrote: post #527
maxehmookau wrote: post #341

I'm in the trial. It's really exciting, not least because form a purely selfish point of view, I might be immune already! ...or not. But it's exciting either way! AMA?

>AMA? Have you experienced any side effects, even mild like injection pain or fatigue? I'm in the Moderna study and feel pretty disappointed that I may have gotten the placebo.

Yes. After my first jab I had mild fever and mild arm pain (in both arms!) for a week.

After the second jab, I had no side-effects.

It's been quite a few months now since my first jab and I have no long-term effects whatsoever.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#642

Post by ImaCake »

mathw wrote: post #632
ilyagr wrote: post #495

Earlier quoted context omitted.

I'm surprised they don't seem to do frequent and regular COVID testing of participants to catch asymptomatic infections. Naively, it would seem worthwhile in order to predict how well the vaccine would slow down the spread. I guess the reason is that the study is narrowly tailored to vaccine approval requirements?

The study is tailored to the standards of vaccine approval, of course it is. They need to prove safety and efficacy, so they design a trial which will allow those factors to be measured. Kind of difficult to prove efficacy if you don't know how many people in your trial were infected with the disease you're trying to vaccinate against though. But do bear in mind as mentioned in other comments this participant was not…

Since this is would presumably be testing for efficacy I guess they would have a number of pre-determined "interim analysis" points in the study when X count of people report becoming positive for the coronavirus. If the proportion infected in the treatment vs control is too high (i.e. lots of vaccinated ppl got sick) they will stop the trial and consider the vaccine a failure. If too few get it, they might stop the trial and immediately move to a Phase III study to confirm their result - that is they accelerate the trial to get the treatment out quicker.

I am unsure if they will have some lower bound for acceleration for this vaccine, since the downsides might not be apparent for a long time.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#643

Post by maxehmookau »

behnamoh wrote: post #571
maxehmookau wrote: post #359

Earlier quoted context omitted.

I have a "red alert" card so if I'm found unconscious a paramedic knows to contact the study team to find out if I'm in the control arm or I've had the active vaccine so they can rule out if it's important to why I was found unconscious! But it is just a piece of paper that the team printed out, and I think I lost it.

>> But it is just a piece of paper that the team printed out, and I think I lost it. loses the single most important medical document that's going to save his life

It's in my iPhone medical ID which I carry round far more often than my wallet. (Paramedics almost always check that here in the UK)

The likelihood of it being of diagnostic usage is pretty low anyway. A vaccine is highly unlikely to cause the sort of reaction that means I won't be conscious.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#644

Post by maxehmookau »

elevenoh wrote: post #500
maxehmookau wrote: post #384

Earlier quoted context omitted.

Oh yeah, that's for sure. The idea that there's a pretty decent chance that I've been vaccinated already which means I don't have to wait for a vaccine is great. My life can begin to go back to normal potentially months before it otherwise would.

>My life can begin to go back to normal potentially months before it otherwise would. Howso? Socialization is a multi-party dynamic. Folks might not care/believe you if you state 'I'm vaccinated' until it's widely accepted.

There's a surprising number of comments about people trusting me.

It's interesting because that's, not once, ever been a concern. If people don't want to spend time with me until vaccination is more widespread, then that's fine. But the intersection between those who don't trust that I've been vaccinated and those who don't trust vaccination anyway is probably pretty large...

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#645

Post by maxehmookau »

whimsicalism wrote: post #505
elevenoh wrote: post #500

Earlier quoted context omitted.

>My life can begin to go back to normal potentially months before it otherwise would. Howso? Socialization is a multi-party dynamic. Folks might not care/believe you if you state 'I'm vaccinated' until it's widely accepted.

Maybe I'm a dunce but I would believe a friend if they say they're vaccinated or already got covid.

Depends on your friends, I guess!

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#646

Post by maxehmookau »

jobigoud wrote: post #517
maxehmookau wrote: post #341

I'm in the trial. It's really exciting, not least because form a purely selfish point of view, I might be immune already! ...or not. But it's exciting either way! AMA?

Do you get to know, at the end of trial, in which group you were?

Yes, at the end of the trial I will be told which group I was in.

That's currently due for March 2021, but things change quickly.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#647

Post by maxehmookau »

chrisrogers wrote: post #601
maxehmookau wrote: post #341

I'm in the trial. It's really exciting, not least because form a purely selfish point of view, I might be immune already! ...or not. But it's exciting either way! AMA?

Did you experience temporary soreness near the location of the shot? Generalized tiredness, etc, that you might associate with a flu shot? How often are your follow-ups?

Yes. I had generalized pain in both arms after the first injection. Not the second. Nothing worse than you'd expect from another vaccination.

Mild fever for 48 hours that meant I was too tired to exercise, but I was more than fine to work. (I'm a software engineer. I think if I had a more manual job, I would've struggled!)

My follow-ups are every 2 months at a local hospital. They take general observations, ask about side effects and take a small blood sample (presumably to test for antibodies)

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#648

Post by maxehmookau »

jjulius wrote: post #512
elevenoh wrote: post #500

Earlier quoted context omitted.

>My life can begin to go back to normal potentially months before it otherwise would. Howso? Socialization is a multi-party dynamic. Folks might not care/believe you if you state 'I'm vaccinated' until it's widely accepted.

I'd assume that one would be socializing with the same groups of friends/family that they had pre-COVID. With that in mind, wouldn't OP have already established a foundation of trust within those groups? Maybe this sounds naive, but why have friends if they're not capable of trusting you?

> Maybe this sounds naive, but why have friends if they're not capable of trusting you?

You'd have to ask my friends. But they're all more interested and curious than suspicious!

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#649

Post by maxehmookau »

tgsovlerkhgsel wrote: post #509
xwdv wrote: post #348

Earlier quoted context omitted.

What if something goes horribly wrong and the vaccine trial causes unwanted side effects? Why risk it, what are they paying you?

What if something goes horribly normally and you catch the virus the vaccine is supposed to prevent? It's a risk tradeoff, different between the phases. I'd probably volunteer for a phase 3 trial if one was available in my area. Phase 1 would be a bit too hot for me.

I'd agree.

I wasn't interested in Phase I. My trial is Phase II/III. I was by no means the first to be vaccinated. Any major, common, reactions had already been pretty safely discounted.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#650

Post by pjc50 »

12bytes wrote: post #615
thebruce87m wrote: post #356

Earlier quoted context omitted.

Maybe a stupid question, but do we need to vaccinate everyone? I remember reading that heard immunity is 70% or something - so could we get away with leaving the people out that it wasn’t tested on?

i haven't read through all the questions asked here, but yours is perhaps the least stupid i suspect you may already know the answer to your question; of course not everyone needs to be vaccinated - that's the job of any reasonably healthy immune system and this virus, which has not been properly isolated by the way, and that comes directly from the CDC, is not particularly dangerous, and that comes directly from the…

.. where did you get all this nonsense from?
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