To us in Brazil, this vaccine is particularly interesting because not only is it one of the vaccines being tested here (together with FIOCRUZ in Rio de Janeiro; another one is Coronavac from Sinovac together with Instituto Butantan in São Paulo), but also there's already an agreement to manufacture it in the country (https://portal.fiocruz.br/noticia/fiocruz-assina-contrato-de...).
Vaccine hopes rise as Oxford jab prompts immune response among old and young
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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#72Earlier quoted context omitted.
This IS good news. Now (soon, hopefully) people can acquire immunity through a vaccine, instead of through a virus that leaves long-lasting damage to the body (in particular, but not limited to, the brain).
> leaves long-lasting damage to the body (in particular, but not limited to, the brain). In what percentage of people who get COVID-19 is there long-lasting damage to the body? What other conditions did the people who get long-lasting damage to the body have? How does these numbers compare with other diseases? Would appreciate citations.
Most people with COVID even with few symptoms have a loss of smell. If you like numbers, I read that around 80% of people with COVID report loss of smell.
And this is one kind of neurological effect. This is a more global view of how the virus could affect the brain:
https://www.scientificamerican.com/article/what-we-know-so-f...
And I'm not even touching the subjects of damage to the heart, clotting problems, etc.
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#73Earlier quoted context omitted.
There are some stats here for the UK, based on a symptom tracking app that's been active since about March. https://news.sky.com/story/coronavirus-long-covid-warning-as... > One in 20 people with coronavirus are likely to have symptoms for eight weeks or more, according to a new study by King's College London. > The research, which uses data from the COVID Symptom Study App, suggested so-called "long COVID" affects a…
From your first link: 10% had any symptoms lasting longer than four weeks. That’s not “severe long-term effects”. The actual study seems to say 1 in 20 have symptoms for eight weeks, which might be closer to what you could fairly describe as “long-term”, but says nothing about the severity (though I haven’t waded through the whole article). Anyway, the drop-off from 10% having symptoms at 4 weeks to 5% at 8 weeks is…
8 weeks certainly shouldn't be classified as 'long term'.
Long term health effect claims are being made all over the show - if this is the measure that is outrageous reporting.
Most people would worry about 'long term health effects' as they'd usually assume that it's going to go on for years.
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#74Earlier quoted context omitted.
Given that immunity from infection is currently questionable your suggestion doesn't make sense. The reason the findings mentioned in this article are important is because the immune response seems to be stronger than that seen in people that have been infected and recovered. So this vaccine would be better at creating herd immunity than just allowing everyone to get infected. At the same time vaccinations will have…
How is immunity from infection questionable? We had 43 million cases and about a dozen or so reinfections. Not sure if confirmed reinfections reach the double digits yet.
Read the papers on it, antibody tests in people who have previously tested positive for covid have found little or no antibodies in tests taken 3 months after infection. So it appears as if there is a limited/short term immunity after initial infection. The vaccine appears to produce a much stronger immune response, such that antibodies can be identified in tests some time after the vaccination.
You can get limited immunity from the common cold after being infected but you are just as likely to catch it 12 months later anyway. With covid that means we are dealing with it annually, which our health services cannot keep up with.
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#75OK, someone tell me why this isn't the good news it sounds like
Likely long-term results are not known yet. We've already had one vaccine potentially causing side effects that stopped the human trials for a while. (I think it was the Russian one. Please correct me if not)
It was the UK trials of the Oxford and AstraZeneca vaccine after 1 person experienced an adverse reaction - but that's the whole point of the trials and not uncommon so no major worry there, and they were restarted soon after.
[nature.com] https://www.nature.com/articles/d41586-020-02633-6
On a separate note - the voting on this thread at the moment seems pretty wild with some seemingly innocuous comments being downvoted. I don't get it.
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#76A quick summary of were the Oxford vaccine stands since it's hard to follow: - When will the vaccine be ready? After the Phase 3 efficacy data is reported, assuming that the data shows that the vaccine prevents COVID or reduces COVID severity. This happens after enough people in the trial get sick with COVID. Then they unblind the groups and see if the people who got sick were in the control group or the vaccinated g…
Thank you for volunteering and putting your health on the line for the benefit of us all. Even if the risk is small, it takes courage.
I'm assuming you also don't know if you got the active substance or a placebo?
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#77Earlier quoted context omitted.
It's a surrogate outcome. "Prompts immune response" means "we hope it prevents infections". It doesn't necessarily mean it will. This is still good news. But it should be put in perspective, this does not automatically translate to "this vaccine will work fine in both young and old". It just means we can have some higher hopes that it will. Only RCT results of the real infections will show if it really works. (RCT fo…
What's RCT? You mean voluntarily injecting the covid on vaccined very young humans (so negligible risk of death) ?
Randomized Control Trial
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#78Earlier quoted context omitted.
It's a surrogate outcome. "Prompts immune response" means "we hope it prevents infections". It doesn't necessarily mean it will. This is still good news. But it should be put in perspective, this does not automatically translate to "this vaccine will work fine in both young and old". It just means we can have some higher hopes that it will. Only RCT results of the real infections will show if it really works. (RCT fo…
What's RCT? You mean voluntarily injecting the covid on vaccined very young humans (so negligible risk of death) ?
Randomized Controlled Trial: https://en.wikipedia.org/wiki/Randomized_controlled_trial
Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#79Earlier quoted context omitted.
It's a surrogate outcome. "Prompts immune response" means "we hope it prevents infections". It doesn't necessarily mean it will. This is still good news. But it should be put in perspective, this does not automatically translate to "this vaccine will work fine in both young and old". It just means we can have some higher hopes that it will. Only RCT results of the real infections will show if it really works. (RCT fo…
What's RCT? You mean voluntarily injecting the covid on vaccined very young humans (so negligible risk of death) ?
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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young
#80Earlier quoted context omitted.
It's a surrogate outcome. "Prompts immune response" means "we hope it prevents infections". It doesn't necessarily mean it will. This is still good news. But it should be put in perspective, this does not automatically translate to "this vaccine will work fine in both young and old". It just means we can have some higher hopes that it will. Only RCT results of the real infections will show if it really works. (RCT fo…
What's RCT? You mean voluntarily injecting the covid on vaccined very young humans (so negligible risk of death) ?
RCT means a randomized controlled trail. GP is confused. This announcement is about an RCT.
Injecting a disease into volunteers is called a human challenge trial. It is a type of RCT, but it is not what is being discussed here.