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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#41

Post by cheph »

henearkr wrote: post #5
dbetteridge wrote: post #3

OK, someone tell me why this isn't the good news it sounds like

This IS good news. Now (soon, hopefully) people can acquire immunity through a vaccine, instead of through a virus that leaves long-lasting damage to the body (in particular, but not limited to, the brain).

> leaves long-lasting damage to the body (in particular, but not limited to, the brain).

In what percentage of people who get COVID-19 is there long-lasting damage to the body? What other conditions did the people who get long-lasting damage to the body have? How does these numbers compare with other diseases?

Would appreciate citations.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#42

Post by sanketskasar »

godelmachine wrote: post #16

Is this not the one they will launch in India first? Edit1: Just to throw in more info, Oxford plans to scale this up for mass production with Serum Institute of India and AstraZeneca.

It is the same. But you cannot expect a vaccine to work similarly in people of two different regions having major differences in their diet, climate and lifestyles. That's why many vaccine candidates are being tested in multiple countries( read potential markets). Also, I think the UK has preferential rights at least on the initial yield of the vaccine.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#43

Post by henearkr »

rimliu wrote: post #28
henearkr wrote: post #11

Earlier quoted context omitted.

This is a virus with bad long-term effects on the body. Not a good idea to catch it just to get immune.

Nobody knows its long term effect on the body. Especially if you were asymptomatic.

This huge uncertainty is in favor of avoiding taking the risks, rather than the other way.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#44

Post by shotta »

calvinv wrote: post #32
erikrothoff wrote: post #8

Earlier quoted context omitted.

“The programme is progressing well, (but) we’re not there yet,” Hancock said. Looking good, but still months away from rolling out.

if we're back to normalish by spring next year I think that would be a great outcome, if the messaging to the public would be, buckle down until then I think lockdown complaince could go up

That’ll be extra rough for folks in the depths of winter.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#45

Post by dageshi »

jlokier wrote: post #18
arethuza wrote: post #9

Earlier quoted context omitted.

That seems fair if they are being expected to rush the development of the vaccine?

It's fair if the degree of disclaiming is proportionate to the need and the pace. They shouldn't be off the hook completely. They should still have to show they have conducted a responsible level of testing and checking for the circumstances, that they are continuing to refine that verification even after widespread deployment, and to motivate that to be done all levels requires some degree of moral hazard remains in…

I think they're mostly producing this on a break even/no profit basis for at least the initial roll out?

If there is some sharing of risk, but no profit to be had (and ultimately profit is what buffers you against risk) then why would you be involved at all? Let some other company take the risk?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#46

Post by [deleted] »

School-Cotton wrote: post #17
henearkr wrote: post #5

Earlier quoted context omitted.

This IS good news. Now (soon, hopefully) people can acquire immunity through a vaccine, instead of through a virus that leaves long-lasting damage to the body (in particular, but not limited to, the brain).

Do you have a source on how common severe long-term effects from Covid are? All I’ve seen are anecdotes.

[deleted]

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#47

Post by MrAlex94 »

aphextron wrote: post #14
dbetteridge wrote: post #3

OK, someone tell me why this isn't the good news it sounds like

>OK, someone tell me why this isn't the good news it sounds like The AstraZeneca vaccine is based on an adenovirus vector, which has never been approved for use in humans. It uses a weakened live virus that can (and apparently has, in the case of the J&J vaccine, which is using very similar tech) cause serious adverse systemic reactions. From what we've seen so far, the safety profile for these vaccines is far worse…

> It uses a weakened live virus that can (and apparently has, in the case of the J&J vaccine, which is using very similar tech) cause serious adverse systemic reactions.

There is no evidence to prove the vaccine has caused any serious adverse effects so far. If that were the case, it is unlikely the Data Safety and Monitoring Board (DSMB) and U.S. Food and Drug Administration (FDA) would recommend resuming the trial.

> After a thorough evaluation of a serious medical event experienced by one study participant, no clear cause has been identified. There are many possible factors that could have caused the event. Based on the information gathered to date and the input of independent experts, the Company has found no evidence that the vaccine candidate caused the event.

https://www.jnj.com/our-company/johnson-johnson-prepares-to-...

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#48

Post by cheph »

henearkr wrote: post #40
cheph wrote: post #31

Earlier quoted context omitted.

> This is a virus with bad long-term effects on the body. In what percentage of people who get COVID-19 are there bad long-term effects? What other conditions did the people get bad long term effects have? How does these numbers compare with other diseases? Would appreciate citations.

Damage to the heart, the brain, even for mild or asymptotic cases. My references are previous posts on HN or on phys.org as you can easily search it. As you said there are scarce data yet, but the risks are scary. In these conditions, it's obvious one should avoid relying on a herd immunity induced by the virus.

> My references are previous posts on HN or on phys.org as you can easily search it.

And you could cite a claim you are making. Without numbers it is hard to say if this is a good basis for decisions.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#49

Post by hannob »

dbetteridge wrote: post #3

OK, someone tell me why this isn't the good news it sounds like

It's a surrogate outcome. "Prompts immune response" means "we hope it prevents infections". It doesn't necessarily mean it will.

This is still good news. But it should be put in perspective, this does not automatically translate to "this vaccine will work fine in both young and old". It just means we can have some higher hopes that it will.

Only RCT results of the real infections will show if it really works. (RCT for the vaccine is running and first results are expected soon.)

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#50

Post by roman030 »

mav3rick wrote: post #36
LatteLazy wrote: post #24

Earlier quoted context omitted.

Why would old people get sick from the vaccine? If we let everyone get it in Q2 2020, millions would have died when we ran out of ventilators.

Not supporting the OP's assertions, but vaccines have some timid / less potent form of the virus.

Imagine throwing your phone at the wall and it shatters into 1000 pieces. Now try calling someone with one of these pieces.
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