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Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

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Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#31
post #4

For comparison, from what I've read the typical annual influenza fatality rate is around 0.1% (don't know what the under-70 rate would be). So, this puts covid-19 solidly in the uncanny valley of viral mortality rates; not low enough to be "just like a flu", not high enough to justify shutting down the world. No wonder opinions on it are so divided.

(1) A COVID-19 infection can have long-term effects even in young people. (2) We all have seen the images of hospitals overwhelmed with COVID-19 patients, not having enough breathers, etc. For some reason this doesn't happen with the typical annual influenza ... If you reduce everything to statistics about mortality rates, you are missing very important parts of the picture.

(1) So can the flu but we move along hunkey dorie.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#32
post #16

Here's another recent meta-study (preprint) on the same topic: Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications https://www.medrxiv.org/content/10.1101/2020.07.23.20160895v... Abstract: This paper assesses the age specificity of the infection fatality rate (IFR) for COVID-19 using results from 29 seroprevalence studies as well as…

>This isn't good news, really, not for middle-aged-adults anyway.

Or for anybody who knows middle aged and older people, especially if you spend time with them. I am honestly more concerned about killing my parents than dying myself of covid-19. This is why I skipped my mom's birthday for example, because I had pretty mild cold-like symptoms... or maybe mild covid-19.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#33

As others say, this is way too much to say "meh", but I do think it needs a rethink of the lockdown strategies. Lockdowns kill people; people with cancer, people who need surgeries, people who lose income to support themselves. Clearly, so does Covid, and we need to balance it. Can we do better, as societies, if we aggressively protecting old and vulnerable people, and let fitter people continue with their lives? Thi…

There's plenty of evidence of long-term damage even in young and barely symptomatic cases - it's not a binary "dead/not dead" outcome.

What if the virus causes substantial disease burden years to decades down the road? We can't know, and should take every precaution to prevent its spread.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#34
post #16

Here's another recent meta-study (preprint) on the same topic: Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications https://www.medrxiv.org/content/10.1101/2020.07.23.20160895v... Abstract: This paper assesses the age specificity of the infection fatality rate (IFR) for COVID-19 using results from 29 seroprevalence studies as well as…

> > reaching 0.4% at age 55 > This isn't good news, really, not for middle-aged-adults anyway.

Overall mortality at age 55 is about 0.5%: https://www.statista.com/statistics/241572/death-rate-by-age...

In general, COVID-19's IFR by age is pretty close to overall mortality. So even in unrestricted spread, limited by only herd immunity, at worst direct deaths from it would less than double your chances of dying in a year.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#35
post #33

As others say, this is way too much to say "meh", but I do think it needs a rethink of the lockdown strategies. Lockdowns kill people; people with cancer, people who need surgeries, people who lose income to support themselves. Clearly, so does Covid, and we need to balance it. Can we do better, as societies, if we aggressively protecting old and vulnerable people, and let fitter people continue with their lives? Thi…

There's plenty of evidence of long-term damage even in young and barely symptomatic cases - it's not a binary "dead/not dead" outcome. What if the virus causes substantial disease burden years to decades down the road? We can't know, and should take every precaution to prevent its spread.

For example? I haven't seen a single paper showing such long-term consequences in healthy people are significantly more likely than from other viral infections. We'd especially expect to be seeing a large number of such cases in Sweden, should it be common, given they had no lockdown and a large number of infections.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#36

As others say, this is way too much to say "meh", but I do think it needs a rethink of the lockdown strategies. Lockdowns kill people; people with cancer, people who need surgeries, people who lose income to support themselves. Clearly, so does Covid, and we need to balance it. Can we do better, as societies, if we aggressively protecting old and vulnerable people, and let fitter people continue with their lives? Thi…

Antibody tests do miss many cases, especially those with mild or no symptoms. Some patients are able to fight off the infection before antibodies are produced, or antibody production fades away quickly.

https://www.bmj.com/content/370/bmj.m3364

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#37

Earlier quoted context omitted.

> Lockdowns kill people Agreed. But what causes lockdowns? An uncontrolled pandemic. What does uncontrolled pandemic also cause? Collapse of healthcare infrastructure, which is a civil emergency that also results in countless deaths. Lockdowns, as implemented in places like the US, are a reactive measure because of a system-wide failure to adopt and maintain proactive measures needed to control things. You don’t arri…

I'm not demonizing lockdowns. They have a use, for sure, and they save lives. I just mean, they have their own downsides too, and we should use new data to evaluate how we implement them. It is now clear societies cannot really afford full, long-term, unconditional lockdowns. We have to pick and choose what we do, stratifying by age/health conditions seems a good way about it to me.

Nowhere outside of places New Zealand and Taiwan has had long-term, unconditional lockdowns, and nowhere in the US has reached anywhere near this level of restrictions. I live in a state that ostensibly had “extreme” lockdowns and whole cities and communities decided themselves exempt from the orders with zero consequences.

It’s also impossible to stratify people on the basis of health in the US because not everyone is cognizant of their health status or risk factors, certainly the government has no insight into these beyond the crudest levels. Age also doesn’t really work because the lack of social safety nets mean older workers have to remain employed or rely on younger cohorts in order to survive.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#38

As others say, this is way too much to say "meh", but I do think it needs a rethink of the lockdown strategies. Lockdowns kill people; people with cancer, people who need surgeries, people who lose income to support themselves. Clearly, so does Covid, and we need to balance it. Can we do better, as societies, if we aggressively protecting old and vulnerable people, and let fitter people continue with their lives? Thi…

The sad reality is that broad, indiscriminate lockdowns are the only real tool available to some "world powers". We know we can manage the covid pandemic with ubiquitous testing and targeted temporary lockdowns. But there is no testing capacity.

Which means ... it's not really possible to rethink the lockdown strategies. Given a choice between a thing that directly kills people, and something that more people die from in indirect ways, people are always going to default to preventing the direct deaths.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#39
post #33

As others say, this is way too much to say "meh", but I do think it needs a rethink of the lockdown strategies. Lockdowns kill people; people with cancer, people who need surgeries, people who lose income to support themselves. Clearly, so does Covid, and we need to balance it. Can we do better, as societies, if we aggressively protecting old and vulnerable people, and let fitter people continue with their lives? Thi…

There's plenty of evidence of long-term damage even in young and barely symptomatic cases - it's not a binary "dead/not dead" outcome. What if the virus causes substantial disease burden years to decades down the road? We can't know, and should take every precaution to prevent its spread.

This is a very important point. We don't know enough about long term effects yet.

In the same vein, we do not even know if herd immunity really is a thing here, and what thing it would be. E.g. the guy from Hong Kong who got reinfected (first time severe symptoms, second time no symptoms) was probably infectious the second time again. Herd immunity only works if the people who are immune are not infections and therefore cannot (re-(infect each other and more importantly the vulnerable population.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#40

Earlier quoted context omitted.

(1) Need sources. This is extremely extremely extremely rare if so, and very speculative and unproven with no hard science. (2) This is also extremely extremely rare in under 70 population. Horrible things happen ALL THE TIME but there's a statistically miniscule chance of it happening to you. Everything in life is dangerous if you look at life the way you're championing. I think you might just be scared of LIFE in g…

1) long covid is still being studied, obviously, but there are many cases of it - https://bgr.com/2020/08/21/coronavirus-symptoms-long-covid-s... It’s a disease that attacks your organs, there’s going to be damage.

I don't think anybody's denying it exists. What hasn't been shown is if long-term consequences are more prevalant with covid than with other viral lung infections.
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