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Beyond that, I would wholeheartedly recommend people take 3000 UI per day while COVID is floating around. (3 drops from your typical Vitamin D in drop form)
So, on average, 200ish times the recommended daily dose? No wonder she had problems.
I think 130 times recommended. Or perhaps only 30 times what should be recommend. It's thought the old recommended dose is to low for some people or some situations. Which is why they really want to push it up as much as possible for all because it will save lives. Hence these studies. I'm doing 1000UI daily given current data and covid-19.
Same question but say you take a high supplement and then have a day in the sun?
"In terms of renal involvement, hypercalcemia can cause kidney injury both acutely and chronically.
Hypercalcemia can cause acute kidney injury primarily by 2 mechanisms: afferent arteriolar constriction and intravascular volume depletion from a diuretic effect through activation of calcium-sensing receptor at the sodium–chloride cotransporter in the loop of Henle."
Use of vitamin D drops leading to kidney failure in a 54-year-old man Bourne L. Auguste, Carmen Avila-Casado, Joanne M. Bargman CMAJ Apr 2019, 191 (14) E390-E394; DOI: 10.1503/cmaj.180465
There's a cool histological slide showing the actual calcium deposits in the kidneys that were causing some problems.
This fella had a couple other things going on as well that likely contributed to this, but food for thought.
https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessiona...
Are there any other opinions?
On this page it says the recommended dosage is 600 IU https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessiona... Are there any other opinions?
Can you OD on vitamin D from getting too much sun? Or does your body have a way to turn off the production? Same question but say you take a high supplement and then have a day in the sun?
Exogenous UV not in the skin will not be photo-degraded, so supplement + sun may lead to overdose.
Can you OD on vitamin D from getting too much sun? Or does your body have a way to turn off the production? Same question but say you take a high supplement and then have a day in the sun?
I don't know if that's "OD"ing specifically. But I am replying because I get the exact same thing when I'm out in the sun all day long. I do feel like you probably can't get 130000 UIs from being in the sun in a single day.
The title doesn’t match the abstract. This isn’t a study of the tolerable upper limit of Vitamin D intake. It’s a case report of a single individual who was taking astronomical doses of Vitamin D with disastrous consequences. It’s certainly possible to take too much vitamin D without coming anywhere near the silly doses this person was consuming. Anyone taking aggressive vitamin D doses should invest in a vitamin D t…
Can you OD on vitamin D from getting too much sun? Or does your body have a way to turn off the production? Same question but say you take a high supplement and then have a day in the sun?
Vitamin D plays a big role as a calcium-regulatory hormone, and too much of it can lead to elevated levels of calcium in the blood.
However, in a normal, healthy adult, the body's own feedback-inhibitory mechanisms will just downregulate synthesis of the hormone when too much calcium is detected in the blood.
If you're sick or have other things going on (like cancer or taking too many Vitamin D tablets), however, it can be a problem:
Papapetrou PD, Bergi-Stamatelou M, Karga H, Thanou S. Hypercalcemia due to sun exposure in a patient with multiple myeloma and elevated parathyroid hormone-related protein. Eur J Endocrinol. 2003 Mar;148(3):351-5. doi: 10.1530/eje.0.1480351. PMID: 12611617.
https://pubmed.ncbi.nlm.nih.gov/12611617/
Use of vitamin D drops leading to kidney failure in a 54-year-old man Bourne L. Auguste, Carmen Avila-Casado, Joanne M. Bargman CMAJ Apr 2019, 191 (14) E390-E394; DOI: 10.1503/cmaj.180465
https://www.cmaj.ca/content/191/14/E390
Naik MA, Banday KA, Najar MS, Reshi AR, Bhat MA. Vitamin D intoxication presenting as acute renal failure. Indian J Nephrol. 2008;18(3):125-126. doi:10.4103/0971-4065.43693
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813130/
"Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work."
https://www.mayoclinic.org/diseases-conditions/hypercalcemia....
Here's the graphic on Vitamin D synthesis in the body from Wikipedia, you can see that the enzyme CYP27B1 is inhibited by elevated levels of calcium in the blood, so calcidiol is shunted into production of an inactive metabolite. This is what would be happening if you were out sunbathing for 123123 hours per day.
https://en.wikipedia.org/wiki/File:VitaminDSynthesis_WP1531....
