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India's new paper Covid-19 test

bbc.com

11–20 of 31 posts

Re: India's new paper Covid-19 test

#11
post #6
post #3

Earlier quoted context omitted.

Did you read the text before making this comment? > They found that the new test had 96% sensitivity and 98% specificity.

I'm not sure if thats too good - 98% specificity means that for 1000 infected people, 20 will get away unidentified (false negative). But probably better than other tests, i guess?

But I guess that's why, in some countries, people who had a high probability of catching the virus are told to stay in quarantine even if they tested negative.

Re: India's new paper Covid-19 test

#14
post #10
post #3

Earlier quoted context omitted.

Did you read the text before making this comment? > They found that the new test had 96% sensitivity and 98% specificity.

In the UK, only 2.7% of tests are returning positive results. At the end of July, this figure was 0.4%, which puts a floor on the specificity of the existing testing technology at 99.6%. If a test with only 98% specificity were used in the UK, the test would have a positive predictive value (the chance that the positive test represents a true positive result) of about 50%, far worse than existing technology.

Yeah, that's the fundamental problem with this kind of cheap, quick test - it's really hard to get good enough specificity to make them viable. This is part of the reason the UK has rejected pretty much every such test it's tried, with Matt Hancock infamously declaring that "no test is better than a bad test" (though I think those tests were rather worse than this one).

Re: India's new paper Covid-19 test

#15
post #3

I have already witnessed false-positives with much more elaborate Covid tests so I would be surprised if this test is actually realiable.

Did you read the text before making this comment? > They found that the new test had 96% sensitivity and 98% specificity.

[deleted]

Re: India's new paper Covid-19 test

#16
post #8

Interesting, I was led to believe this kind of research could only happen when we let drug companies gouge us for obscene profits.

Right? Very good job from CSIR Govt. Labs - https://www.csir.res.in/

CSIR is more of a system of labs than one big organization/lab. It provides a legal framework for the state to start targeted labs which investigate specific fields of study. There are CSIR labs studying everything from ceramics to biology.

Re: India's new paper Covid-19 test

#17
post #6
post #3

Earlier quoted context omitted.

Did you read the text before making this comment? > They found that the new test had 96% sensitivity and 98% specificity.

I'm not sure if thats too good - 98% specificity means that for 1000 infected people, 20 will get away unidentified (false negative). But probably better than other tests, i guess?

The text states this is comparable to PCR tests (molecular tests). So it is really not bad.

Re: India's new paper Covid-19 test

#18
The preprint Rapid, field-deployable nucleobase detection and identification using FnCas9 [1]:

> Here, we present FnCas9 Editor Linked Uniform Detection Assay (FELUDA)... At the heart of such a detection procedure lies the property of CRISPR proteins to accurately bind to target DNA or RNA, undergo conformational changes leading to cleavage of targets generating a reporter-based signal outcome.

> We then developed a pipeline to adapt FELUDA for an affinity-based fluorescent read-out system, where the amplification step generates biotinylated products which can then be immobilized on magnetic streptavidin beads.

The end-to-end process is similar to PCR and requires specialists to collect samples that are then processed by a lab.

[1] https://www.biorxiv.org/content/10.1101/2020.04.07.028167v2

Re: India's new paper Covid-19 test

#19
post #10
post #3

Earlier quoted context omitted.

Did you read the text before making this comment? > They found that the new test had 96% sensitivity and 98% specificity.

In the UK, only 2.7% of tests are returning positive results. At the end of July, this figure was 0.4%, which puts a floor on the specificity of the existing testing technology at 99.6%. If a test with only 98% specificity were used in the UK, the test would have a positive predictive value (the chance that the positive test represents a true positive result) of about 50%, far worse than existing technology.

WHere are you getting 2.7% from. In the last 24 hours in Scotland 12.8% of people tested were positive.

It's been above 10%, I think, now for over two weeks.

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