11–20 of 141 posts
Experimental drug, through the efforts of terminally ill, are able to discover/show/validate quite powerful benefits, but the drug is too dangerous to use itself. So we stop it.
It is progress and many times, progress is not easy nor cost free. Thank you to all those who, even in their terminally ill state, helped progress treatments for others.
Please edit the title to fully spell out Multiple Sclerosis. At first I thought what does Microsoft have to do with nerve coatings?
I know this is a tech/curiosity forum, and that it might be confusing for a second, but I feel a bit "Black Mirrorred" if the acronym MS fully belongs to Microsoft on Hacker News. I'm against giving them that power when it's in conflict with a scientific concept such as Multiple Sclerosis as scientific thinking is part of Hacker News.
With that said, I'm fine with whatever the mods decide, I simply want the mods to have considered my argument.
Please edit the title to fully spell out Multiple Sclerosis. At first I thought what does Microsoft have to do with nerve coatings?
I see your point as I thought it for a second as well. At the same time, MS is quite a well-known acronym for Multiple Sclerosis even among lay people (anecdata: I am a layperson and know no one who has MS). I know this is a tech/curiosity forum, and that it might be confusing for a second, but I feel a bit "Black Mirrorred" if the acronym MS fully belongs to Microsoft on Hacker News. I'm against giving them that pow…
Later edit: and I've never seen the name of the disease acronymed, it's always been in full.
Earlier quoted context omitted.
I see your point as I thought it for a second as well. At the same time, MS is quite a well-known acronym for Multiple Sclerosis even among lay people (anecdata: I am a layperson and know no one who has MS). I know this is a tech/curiosity forum, and that it might be confusing for a second, but I feel a bit "Black Mirrorred" if the acronym MS fully belongs to Microsoft on Hacker News. I'm against giving them that pow…
Just to nitpick, if you're not a native english speaker MS may not even mean multiple sclerosis to you. In my language the acronym would be "SM". Later edit: and I've never seen the name of the disease acronymed, it's always been in full.
Good nitpick :)
[1] https://www.hersenstichting.nl/hersenaandoeningen/multiple-s... <-- I know that sourcing this is a bit much, but I figured that some of you non-Dutch speakers might feel whimsical enough to look at some Dutch text for funzies. Or maybe it's just me who looks at random texts of other languages O:)
They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? I believe it is though, and I also believe that remyelination is always occurring but hampered in MS and even regular people. Taking away the inflammatory signal will result in remyelination without any stem cells in my opinion.
> They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? A while. The primary symptom of MS, the demylination, is caused by the immune system attacking the myelin. The _why_ of the immune system's attack is still unknown at this point in time, but that it _does_ has been known since at least 1965, with Schumacher's criteria.
While involvement of the immune system seems likely, and certainly most treatments target the immune system, I don’t think causality has been rigorously demonstrated. It has however been a few years since I looked into it.
As an aside, ISTM quite likely that there may be several causes for MS.
Burying the lede a bit: the drug can’t be used because its safety profile is unacceptable, but the possible mechanism might be targetable by other future drugs. Translation: come back in 2040.
They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? I believe it is though, and I also believe that remyelination is always occurring but hampered in MS and even regular people. Taking away the inflammatory signal will result in remyelination without any stem cells in my opinion.
> They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? A while. The primary symptom of MS, the demylination, is caused by the immune system attacking the myelin. The _why_ of the immune system's attack is still unknown at this point in time, but that it _does_ has been known since at least 1965, with Schumacher's criteria.
Earlier quoted context omitted.
I see your point as I thought it for a second as well. At the same time, MS is quite a well-known acronym for Multiple Sclerosis even among lay people (anecdata: I am a layperson and know no one who has MS). I know this is a tech/curiosity forum, and that it might be confusing for a second, but I feel a bit "Black Mirrorred" if the acronym MS fully belongs to Microsoft on Hacker News. I'm against giving them that pow…
Just to nitpick, if you're not a native english speaker MS may not even mean multiple sclerosis to you. In my language the acronym would be "SM". Later edit: and I've never seen the name of the disease acronymed, it's always been in full.
They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? I believe it is though, and I also believe that remyelination is always occurring but hampered in MS and even regular people. Taking away the inflammatory signal will result in remyelination without any stem cells in my opinion.
If it only were this simple.
Earlier quoted context omitted.
> They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? A while. The primary symptom of MS, the demylination, is caused by the immune system attacking the myelin. The _why_ of the immune system's attack is still unknown at this point in time, but that it _does_ has been known since at least 1965, with Schumacher's criteria.
I don’t think it’s that settled at all, certainly not in 1965. Prineas in 2001 showed that MS progression may occur in the absence of immune cells and inflammation, for example [0], and people have complained of progression even when taking extremely strong immunosuppressants. While involvement of the immune system seems likely, and certainly most treatments target the immune system, I don’t think causality has been…
That in itself doesn't in any way mean that MS wouldn't be classified as autoimmune, however. If there is a high degree of immune system involvement, then it is generally classified as autoimmune, or immune-mediated. And that had been demonstrated. Such as in this [0] paper.