MS treatment a step closer after drug shown to repair nerve coating
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Re: MS treatment a step closer after drug shown to repair nerve coating
#2It’s kind of disappointing that this drug won’t be used as a treatment. I get that this drug has dangerous side effects but life with MS is terrible and the life expectancy is short 5-10 years.
I fully believe that for chronic life threatening diseases people should be allowed to try all sorts of treatments that would be deemed unsafe.
Re: MS treatment a step closer after drug shown to repair nerve coating
#3Burying the lede a bit: the drug can’t be used because its safety profile is unacceptable, but the possible mechanism might be targetable by other future drugs.
Translation: come back in 2040.
Re: MS treatment a step closer after drug shown to repair nerve coating
#4It’s kind of disappointing that this drug won’t be used as a treatment. I get that this drug has dangerous side effects but life with MS is terrible and the life expectancy is short 5-10 years. I fully believe that for chronic life threatening diseases people should be allowed to try all sorts of treatments that would be deemed unsafe.
It mat not be only the safety profile, but also the fact that drug patent has expired in 2016.
I am sure they’ll come up with an alternative that may have similar or better safety profile and could pay for clinical trials.
No company is going to finance Phase 3 trial on patent free drug.
Re: MS treatment a step closer after drug shown to repair nerve coating
#5It’s kind of disappointing that this drug won’t be used as a treatment. I get that this drug has dangerous side effects but life with MS is terrible and the life expectancy is short 5-10 years. I fully believe that for chronic life threatening diseases people should be allowed to try all sorts of treatments that would be deemed unsafe.
Indeed. For those with an aggressive form of the disease, I suspect they might be willing to try it and trade MS symptoms for something else at least for a time. Still this is providing some hope that it's at least possible to reverse the damage.
Re: MS treatment a step closer after drug shown to repair nerve coating
#6It’s kind of disappointing that this drug won’t be used as a treatment. I get that this drug has dangerous side effects but life with MS is terrible and the life expectancy is short 5-10 years. I fully believe that for chronic life threatening diseases people should be allowed to try all sorts of treatments that would be deemed unsafe.
What you said about life expectancy is not that clear, so I will clarify: average life expectancy for MS sufferers is 5-10 years shorter than the norm, but this gap continues to narrow.
Re: MS treatment a step closer after drug shown to repair nerve coating
#7They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? I believe it is though, and I also believe that remyelination is always occurring but hampered in MS and even regular people. Taking away the inflammatory signal will result in remyelination without any stem cells in my opinion.
Re: MS treatment a step closer after drug shown to repair nerve coating
#8Please edit the title to fully spell out Multiple Sclerosis. At first I thought what does Microsoft have to do with nerve coatings?
Re: MS treatment a step closer after drug shown to repair nerve coating
#9They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? I believe it is though, and I also believe that remyelination is always occurring but hampered in MS and even regular people. Taking away the inflammatory signal will result in remyelination without any stem cells in my opinion.
> They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science?
A while. The primary symptom of MS, the demylination, is caused by the immune system attacking the myelin. The _why_ of the immune system's attack is still unknown at this point in time, but that it _does_ has been known since at least 1965, with Schumacher's criteria.
Re: MS treatment a step closer after drug shown to repair nerve coating
#10They state very bluntly that MS is an autoimmune disease... when did this become clear to mainstream science? I believe it is though, and I also believe that remyelination is always occurring but hampered in MS and even regular people. Taking away the inflammatory signal will result in remyelination without any stem cells in my opinion.
> when did this become clear to mainstream science?
Well at least 10 years ago a close friend of mine was already being treated with immunomodulators, and it wasn't a cutting edge therapy.