41–50 of 138 posts
Anyone with first hand experience of LSD ?
Perception of time is altered (slowd down mostly), you can see intricate pulsating, kaleidoscopic, patterns in ordinary things (flowers, the floor, carpet, etc), you get deep thoughts and feelings (can be a rollercoaster), it greatly enhances music (it's like seeing in color for the first time). Sex on it is not bad either...
Never had a bad trip, ymmv.
Anyone with first hand experience of LSD ?
So does exercise.
> Animal studies have implicated the neurotrophin BDNF and the growth factor IGF‐1 in mediating the beneficial effects of exercise on hippocampal function and structure as well as cognition. In humans, findings are less clear since exercise‐induced increases in peripheral BDNF have been consistently shown only immediately after a single bout of aerobic exercise. Studies involving longer exercise interventions (i.e., 6 weeks up to 1 year) have reported mixed results. While the majority of reports have found no changes in circulating BDNF and IGF‐1 at the end of the training period, Zoladz and colleagues (2008) demonstrated increased plasma BDNF after 5 weeks of endurance training in physically active male adults. Further, Leckie et al. (2014) found that 1 year of moderate‐intensity walking significantly elevated serum BDNF only in individuals older than 65 years of age. Lastly, Heisz et al. (2017) reported that, although no group differences in serum BDNF were found following 6 weeks of high‐intensity interval training in young adults, participants with greater fitness improvements had higher serum BDNF levels than their counterparts with lower fitness gains.
Anyone with first hand experience of LSD ?
But, it also gave me some interesting experiences, like the confusion of senses. Truly smelling colors was a weird one, one that I remember very vividly. Other than that, it’s lots of fireworks for the mind.
It's fascinating that a monthly visit to your local shaman may still be more safe and effective for depression, anxiety, and cognitive decline than anything western medicine has been able to produce.
[1] https://www.forbes.com/sites/abbierosner/2020/02/21/microdos...
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463489/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343205/
[4] https://www.beingpatient.com/could-psychedelics-help-treat-a...
Earlier quoted context omitted.
In the Abstract section it is shown that 20 micrograms does not increase BDNF levels after 2 hours, as opposed to 5 micrograms. It is shown however that it increases after 4 hours. That was a little confusing
And 10 micrograms does not increase it. So 5 and 20 does, but 10 does not?
Does recovery from brain damage increase the same growth factor?
1. Plasma brain-derived neurotrophic factor levels after severe traumatic brain injury. https://www.tandfonline.com/doi/abs/10.3109/02699052.2015.10.... Brain Injury Journal.
Anyone with first hand experience of LSD ?
I used it at a birthday party a few years ago. My main takeaways were twofold: First, it made me understand the concept of good and bad "vibes" w.r.t. to drug use. It was clear that the experience of taking LSD recreationally in a group of people was a much a social experience as a chemical one. Keeping the "vibe" positive, by playing the right kind of music, staying chill, and saying and doing the right things, was…