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The First Randomized Controlled Trial on Vitamin D and Covid-19

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291–300 of 401 posts

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#291
post #30

Non-white skinned people: sunlight may not be enough to increase your vitamin D. https://www.google.com/search?q=dark+skin+vitamin+d+minutes

I haven't been tested for Vitamin D deficiency. But... and I'm very easily wrong here, but... wouldn't taking a multi vitamin make this testing unnecessary for the most part?

I mean, don't get me wrong, it's always best to test, but diminishing returns and all, wouldn't most people most of the time be fine with just taking one?

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#292

Earlier quoted context omitted.

Using online labs it's super cheap to get it done yourself for less than $50/test. Not worth dealing with insurance BS and your doctor's likely nonsensical ravings about it, just do it and reimburse using your HSA if you have one.

$50/test is a significant cost for many people (many of whom don't have HSAs).

Yes, but it's still cheaper than the much higher price a major lab might try to charge your insurance, plus the price of a doctor visit.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#293

Earlier quoted context omitted.

It's useful to note that this study doesn't need to stand on its own as evidence. It contributes to a growing body. As most of you may have already seen, there is a lot of observational evidence that people with low vitamin D have the worst C19 outcomes. Obviously, correlation by itself doesn't mean causation. But it is a hint. On top of the hint, we already have dozens of RCTs that vitamin D supplements suppress res…

We actually have an expert on this comment here quite often, too high Vit D dose can cause problems with calcium: https://news.ycombinator.com/user?id=devaboone And she's done a series on it: https://www.devaboone.com/post/vitamin-d-part-1-back-to-basi...

I don't think her point was that people shouldn't take Vitamin D to combat Covid. Her point is that people shouldn't be taking high dosages of Vitamin D as a preventative against Covid as the risks can outweigh the rewards. But for those who already have Covid, the risk and rewards may be significantly skewed in favor of Vitamin D, as per this study.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#294

Earlier quoted context omitted.

It's useful to note that this study doesn't need to stand on its own as evidence. It contributes to a growing body. As most of you may have already seen, there is a lot of observational evidence that people with low vitamin D have the worst C19 outcomes. Obviously, correlation by itself doesn't mean causation. But it is a hint. On top of the hint, we already have dozens of RCTs that vitamin D supplements suppress res…

> there is a lot of observational evidence that people with low vitamin D have the worst C19 outcomes. Obviously, correlation by itself doesn't mean causation. But it is a hint. It's a pretty useless one in this case. Old people are much more likely to have vitamin D deficiency. They are also more likely to die of COVID. The low vitamin D is a marker of frailty, not a cause.

According to the study being discussed you're clearly wrong.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#295

Earlier quoted context omitted.

A daily dose of 2000-4000 is enough and is very safe. 42% of Americans are deficient, much more the darker your skin is. https://www.healthline.com/nutrition/vitamin-d-deficiency-sy...

The literature states 1000-2000 is safe for basically anyone, but you really shouldn't be taking more than that without actually going to a doctor and getting your deficiency confirmed. Just because you have darker skin, it doesn't mean taking a higher oral dose won't cause other issues. IIRC daily doses above 2000 over a longer timespan can (infrequently) cause your vitamin B12 levels to fall off, and/or the amount…

If you have an easy access doctor around to ask, I completely agree with that!

If you're not going to see a doctor about this, for laziness/poverty/whatever reasons, I think the average risk from not taking Vitamin D is vastly bigger than the risk from taking it.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#296
post #258
post #228

Earlier quoted context omitted.

Yup, 60kIU from my understanding. And here I am wondering if the 2kIU I'm doing would have any effect...

The amount used as an interventional or short term treatment can greatly exceed what is a prudent amount to take daily. Taking 50k/day long term is probably a bad idea.

No probably about it, it’s a disastrous idea.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#297
post #24

Earlier quoted context omitted.

Yes, this is strong. Worth noting the limitations though: > Randomization generated groups with comparable percentage of unfavorable risk factors as there was no significant difference in subjects with at least one risk factor, except for high blood pressure and diabetes mellitus, known risk factors for unfavorable disease progression [2], which were more frequent in patients not treated with calcifediol. These are H…

Is BMI a good indicator of obesity, though?

I'm 6' and 84kg (185lbs), I recently had a full health checkup. I do cardio and calaesthebics 90 mins a day during weekdays. I'm lean, not bulky. The top finding of the report. Overweight, consider a healthier diet and more exercise.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#298
post #9
post #2

Noteworthy that this is in combination with anti-viral drugs at hospital admission: hydroxychloroquine (400 mg every 12 hours on the first day, and 200 mg every 12 hours for the following 5 days), azithromycin (500 mg orally for 5 days). Regardless, I'm going to assume this means being outside and getting sun is good for me.

To be clear, all patients received these supplemental drugs, as at the time they were considered the best standard of care. (Also to be clear: they're not anti-virals.) Of the 75 patients in the trial, 50 people received additionally Vitamin D3 supplementation (in the form of calcifediol), and 25 did not. Notably, though, diabetes and high blood pressure were substantially more frequent in the control group, which ar…

Diabetes and high blood pressure are significant risk factors, but I wouldn't go as far as calling them huge, certainly not capital-letter huge.

https://www.nature.com/articles/s41586-020-2521-4

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#299

Earlier quoted context omitted.

And it's also summertime in the northern hemisphere, which means less vitamin-D deficiency. Coincidence?

Does it work the same way if you take oral vitamin D supplement? My skin is allergic to the sun (it hurts it bad) but I take daily vit D supplement.

It's actually a lot better. Even in countries with near constant sunlight, d vitamin deficiency bus prevalent. It's more related to our lifestyle than just geographic location.

Re: The First Randomized Controlled Trial on Vitamin D and Covid-19

#300
Experts and health authorities were adament to tell us that vitamins have zero effect against COVID. Not: we don't know and taking a Vitamin C can't hurt, unless you count an upset stomach. But: stop sharing fake health information, this is an infodemic! Just wash your hands.

So to add to the infodemic: selenium and iodine deficiency also increases severity. Take some iodized salt and Brazil nuts now, or wait 5 months for the authorities to understand that absence of evidence is not evidence of absence. And no matter what Youtube bans you for going against the WHO: tumeric is an efficient antiviral.

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