31–40 of 57 posts
What wasn't so good was catching C. diff. soon after, almost certainly because of the aforementioned antibiotics.
Another treatment of yet another antibiotic dealt with that.
Net result; no IBD.
Purely an anecdote: I wrote in a related thread about 5 years ago how I had an allergic reaction and my guts became a mess after taking antibiotics for the first time in my life (around age 23) [ https://news.ycombinator.com/item?id=10555891 ]. I managed to get better by changing my diet. In 2017 I had another course of antibiotics, got very ill again and was hospitalized, diagnosed with IBD (UC), and spent nearly 13…
Earlier quoted context omitted.
IBD is very different from IBS. IBD is an autoimmune disease with a pathologic diagnosis (ie requires a biopsy and microscopic evaluation for diagnosis). It’s treated as almost autoimmune diseases are. IBS is a syndrome (the S in the name) which usually implies a constellation of findings, but not a specific disease process. From the name you can know that the disease process hasn’t been clearly elucidated.
IBD is a catch-all for several different diseases, which are all poorly understood. There is still a debate over whether or not their cause is physical or psychological. There's a big gap between observing inflammation or related markers and actually understanding the disease. Even within the same subdiagnosis, people respond vastly differently to treatments, which more or less can all be described as intentionally c…
We don’t fully understand most disease processes, even those for which we have some effective treatments.
I don’t think lumping disparates diseases together simply on the axis of “understanding of disease process” is terribly useful.
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Many antibiotics dont actually kill gram negative/positive bacteria, they merely prevent them from reproducing. Now if you want to kill bacteria, look to Russian phages, or swallow some sea water where a 1ml sample will contain billions of phages but its pot luck if any of them are right one's you need for your bacterial infection. One other little know fact about antibiotics, is the penicillin based one's get metabo…
Most antibiotics prescribed for UTI are bacteriocidal. Penicillins like amoxicillin and fluoroquinolones are probably the most popular.
https://blogs.bcm.edu/2018/07/25/antibiotic-ciprofloxacin-in...
https://www.acsh.org/news/2012/04/05/keep-eyes-open-using-ci...
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The standard advice I have seen regarding Creatine as a fitness supplement is to basically just take 5g / day. I have never seen guidance to use it for a few weeks only. Creatine helps replace things that get used up during hard workouts and supports the cellular energy cycle. It wouldn't make sense to just take it for a few weeks because it doesn't do a one-time effect.
Creatine cycling has been a thing since I started lifting more seriously, at least 15+ years ago. There was often a loading period, where you would take more, and a maintenance period, both normally given as a g/kg or mg/kg value of creatine to body weight. I believe the idea was either your body became less responsive to the increase creatine in your system of time or your stores become saturated. I'm not sure what…
For reference: https://supplementclarity.com/do-you-need-to-cycle-creatine/
Antibiotics cured my IBD. Had problems for years. A brief course of amoxicillin and some other, now forgotten, antibiotic (taken for unrelated reasons,) ended it almost immediately. It was amazing. What wasn't so good was catching C. diff. soon after, almost certainly because of the aforementioned antibiotics. Another treatment of yet another antibiotic dealt with that. Net result; no IBD.
I once had to take antibiotics like crazy for a long time because I had some pain in the ass strep that wouldn’t go away. It was quite the experience. Afterwards, my breath was bizarre smelling, I had these horrible sulphuric burps for months, and I couldn’t digest ANYTHING properly. It was misery. I had such painful gas from indigestion so frequently that eating totally lost its appeal. This stacks up right in my ex…
Makes a lot of sense. We know so little about the trillions of bacteria inside of us, and taking a nuke to them all is going to have consequences. There are probiotics tuned for IBD on the market, and one can only imagine the complexities of the ecological dynamics. I personally believe that in 100 years there will be a real bacterial awakening in science understanding how much our microbiome affects so much about ou…
https://www.worldcommunitygrid.org/research/mip1/overview.do
Honestly I thought that was pretty well known already. I knew a girl in college about 20 years ago who had been on massive amounts of anti-biotics, and it ruined her stomach & digestive system in some way. At the time she was having to slowly build up "good" bacterial through some type of specialty yogurts (might just have been probiotics, which were not as prevalent then). It was a multi-year process though, and she…