Antibiotics nearly double risk of developing IBD, doctors warn • Hacker News Board

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#11

Post by bitexploder » Thu, Aug 27, 2020, 9:56 PM UTC

autisticcurio wrote: post #4

azinman2 wrote: post #2

Makes a lot of sense. We know so little about the trillions of bacteria inside of us, and taking a nuke to them all is going to have consequences. There are probiotics tuned for IBD on the market, and one can only imagine the complexities of the ecological dynamics. I personally believe that in 100 years there will be a real bacterial awakening in science understanding how much our microbiome affects so much about ou…

Many antibiotics dont actually kill gram negative/positive bacteria, they merely prevent them from reproducing. Now if you want to kill bacteria, look to Russian phages, or swallow some sea water where a 1ml sample will contain billions of phages but its pot luck if any of them are right one's you need for your bacterial infection. One other little know fact about antibiotics, is the penicillin based one's get metabo…

The standard advice I have seen regarding Creatine as a fitness supplement is to basically just take 5g / day. I have never seen guidance to use it for a few weeks only. Creatine helps replace things that get used up during hard workouts and supports the cellular energy cycle. It wouldn't make sense to just take it for a few weeks because it doesn't do a one-time effect.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#12

Post by refurb » Thu, Aug 27, 2020, 11:08 PM UTC

vharuck wrote: post #9

refurb wrote: post #3

Some observations: - I'm surprised they could find controls who had never received antibiotics. I assume this over some time period and not lifetime - For each exposure to antibiotics, there was a stepwise increase in risk from 1.11 to 1.38 to 1.55 - When they matched them to siblings, the risk went down (1.35 versus 1.88) suggesting a genetic component to the overall risk

My guess is the control group wasn't made of people with no history of antibiotics. They just used the model to predict the risk difference between zero and one time of taking antibiotics. The control was people from the general population, and the "test" was people who had already developed IBD. Though there are people, like me, who are allergic to many common antibiotics. Between some bad reactions in childhood and…

Taking another look, I think they are measuring antibiotic dispensations within the time period. Which makes a ton more sense because I'm imaging the number of people who have never been exposed to an antibiotic over their entire lifetime is pretty small.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#13

Post by ng12 » Thu, Aug 27, 2020, 11:51 PM UTC

I cannot wait until we discover a basic understand of the human microbiome. As a practice, gastroenterology is very good at diagnosing and dealing with cancer and very bad at dealing with anything else. IBS/IBD is basically a blanket diagnosis handed out when your doctor has no idea what's wrong with you.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#14

Post by projektfu » Thu, Aug 27, 2020, 11:54 PM UTC

autisticcurio wrote: post #4

azinman2 wrote: post #2

Makes a lot of sense. We know so little about the trillions of bacteria inside of us, and taking a nuke to them all is going to have consequences. There are probiotics tuned for IBD on the market, and one can only imagine the complexities of the ecological dynamics. I personally believe that in 100 years there will be a real bacterial awakening in science understanding how much our microbiome affects so much about ou…

Many antibiotics dont actually kill gram negative/positive bacteria, they merely prevent them from reproducing. Now if you want to kill bacteria, look to Russian phages, or swallow some sea water where a 1ml sample will contain billions of phages but its pot luck if any of them are right one's you need for your bacterial infection. One other little know fact about antibiotics, is the penicillin based one's get metabo…

Most antibiotics prescribed for UTI are bacteriocidal. Penicillins like amoxicillin and fluoroquinolones are probably the most popular.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#15

Post by CarbyAu » Fri, Aug 28, 2020, 12:22 AM UTC

ng12 wrote: post #13

I cannot wait until we discover a basic understand of the human microbiome. As a practice, gastroenterology is very good at diagnosing and dealing with cancer and very bad at dealing with anything else. IBS/IBD is basically a blanket diagnosis handed out when your doctor has no idea what's wrong with you.

I am not sure but it seems to me like:

-Medical establishment shrugs shoulders "Dunno. [Description-of-symptoms] Syndrome?"

then later:

-Medical establishment knowing look "Yeah we know that one. It is Name-of-cause/discoverer-of-cause disease."

Is this how it works?

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#16

Post by 55555 » Fri, Aug 28, 2020, 12:33 AM UTC

How solid is the evidence that accutane causes IBD? Because most people who took accutane would have first taken antibiotics, which is a more common treatment for acne.

It's strange that these two drugs, with two different mechanisms of action, would both increase risk of IBD.

I took both and I have IBD. Stay away from this stuff unless you really need it.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#17

Post by corty » Fri, Aug 28, 2020, 12:42 AM UTC

Wouldn't the application method be a large influence here as well? I imagine that adverse effects from oral application should be more pronounced in the stomach and bowels than with IV use.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#18

Post by aussieguy1234 » Fri, Aug 28, 2020, 12:50 AM UTC

ng12 wrote: post #13

I cannot wait until we discover a basic understand of the human microbiome. As a practice, gastroenterology is very good at diagnosing and dealing with cancer and very bad at dealing with anything else. IBS/IBD is basically a blanket diagnosis handed out when your doctor has no idea what's wrong with you.

In the last 5 years there has been alot of progress in IBS research, namely the discovery that the low FODMAP diet can effectively treat the condition. This treatment method has been widely studied and confirmed. A dietitian is recommended to administer it properly because it eliminates alot of different foods and is far more complex than just avoiding gluten, for example.

The theory is that certain bacteria fermet FODMAPs into gas, water and other substances which cause the various symptoms of IBS.

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#19

Post by herman_toothrot » Fri, Aug 28, 2020, 12:59 AM UTC

sparkie wrote: post #7

Purely an anecdote: I wrote in a related thread about 5 years ago how I had an allergic reaction and my guts became a mess after taking antibiotics for the first time in my life (around age 23) [ https://news.ycombinator.com/item?id=10555891 ]. I managed to get better by changing my diet. In 2017 I had another course of antibiotics, got very ill again and was hospitalized, diagnosed with IBD (UC), and spent nearly 13…

Have you looked into fecal microbiota transplants (FMT)?

Re: Antibiotics nearly double risk of developing IBD, doctors warn

#20

Post by ineedasername » Fri, Aug 28, 2020, 1:16 AM UTC

Honestly I thought that was pretty well known already. I knew a girl in college about 20 years ago who had been on massive amounts of anti-biotics, and it ruined her stomach & digestive system in some way. At the time she was having to slowly build up "good" bacterial through some type of specialty yogurts (might just have been probiotics, which were not as prevalent then). It was a multi-year process though, and she couldn't eat a lot of types of food in the meantime.