81–90 of 153 posts
I've given glucosamine to my dogs for years, and I can clearly notice a difference in their joint health and how stiff and sore they are after long runs ('long-run': 15-25 miles, measured on GPS collars). When I run out of glucosamine, or just drop off of giving it to them for whatever reason, I see them fall back pretty quickly. And when I restart them on it, I notice a response in a few days. I also give give them…
are there dietary sources of glucosamine?
there's no reason to believe macromolecules like glucosamine benefit the body any more than regular, nutritious food. ingested nutrition generally gets broken down into amino acids and the like in the digestive system before it gets distributed to the rest of the body to be reconsistuted into cells and tissue. cartilage in particular is scaffolding and generally must be constructed by other cells from very basic mole…
It's interesting to see that even on HN people don't know the difference between correlation and causation.
Have you read the paper? They adjust for damn near everything including reverse causation. What confounders do you believe the UK biobank data can't account for?
It's interesting to see that even on HN people don't know the difference between correlation and causation.
I'd guess there's not much cause for it among computer science people. I've noticed this in the past: empirical disciplines are better at this stuff. Still, I can't quite work out if a biology degree would cause somebody to understand it better..
If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews, I can't recommend Dr Stanfields youtube channel high enough: https://www.youtube.com/c/DrBradStanfield/videos Also here is his video on Sulforaphane which Glucosamine activates. He goes into detail as to how this mechanism works. Because of his video/latest…
Is a Cochrane review really a primary source? They're meta-analysis, which I'd think of as secondary. In the case linked, the analysis seems pretty unequivocally to not support supplementing: "We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be consi…
And a study on vitamin a and e etc doesn't tell you much about other supplements. Just like how a study on does whether or not statins are associated with reduced mortality tells you little about whether or not ACE inhibitors are associated with reduced mortality.
Also I don't think op meant primary source as in primary vs secondary sources but meant in the sense of "this doctor primarily uses Cochrane as his source for information"
Earlier quoted context omitted.
Some doctors will prescribe it for off-label use, but this is pretty rare. It's possible to purchase it from overseas websites as it is not scheduled, but this is technically not legal, and it will still cost quite a bit out-of-pocket. With that said, it can definitely be potentially dangerous, and dosing+frequency would have to carefully be paid attention to, as well as monitoring results via blood tests imo, and ha…
Any other advice for folks? What do you think of NR?
It's a hard area to give advice in since everyone is different, so I can't really offer much besides that I think for the best return, someone has to spend a lot of time doing their own research and testing and so on to find out what works for them
I've been supplementing glucosamine along with a large amount of other things for awhile now. I'm not too bullish on it in humans, but it doesn't seem like it hurts, and is definitely cheap: https://nearcyan.com/supplements My latest favorites that I'm a bit more hopeful for are glycine, spermadine, and rapamycin.
On Rapamycin: "The known adverse effects caused by sirolimus and marketed analogs at the doses used in transplant regimens, especially the increased risk of infection due to immunosuppression, as well as dose-dependent metabolic impairment, make it unlikely that chronic, long-term treatment with sirolimus could become a widely used anti-aging agent." Sounds more than a little dangerous, unless you have an illnes like…
Personally, I do think it can likely be taken pretty safely if monitored reasonably, and I am pretty hopeful for it as well. But it's true it's a serious drug so it shouldn't be messed around with as if it's a game.
It's interesting to see that even on HN people don't know the difference between correlation and causation.
Have you read the paper? They adjust for damn near everything including reverse causation. What confounders do you believe the UK biobank data can't account for?
X -> Z If you want to see it yourself, let's simulate this system in R:
# Simulate 1000 trials in which X and Y are random coin tosses (T or F)
# and Z is their sum.
> X Y Z summary(lm(Y ~ X))
Call:
lm(formula = Y ~ X)
Residuals:
Min 1Q Median 3Q Max
-0.6947 -0.6893 0.3053 0.3108 0.3108
Coefficients:
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.694704 0.025816 26.910 summary(lm(Y ~ X + Z))
Call:
lm(formula = Y ~ X + Z)
Residuals:
Min 1Q Median 3Q Max
-2.45e-14 -8.40e-18 2.04e-17 2.04e-17 3.59e-15
Coefficients:
Estimate Std. Error t value Pr(>|t|)
(Intercept) -3.370e-16 6.292e-17 -5.356e+00 1.05e-07 ***
XTRUE -1.000e+00 8.241e-17 -1.213e+16 I've given glucosamine to my dogs for years, and I can clearly notice a difference in their joint health and how stiff and sore they are after long runs ('long-run': 15-25 miles, measured on GPS collars). When I run out of glucosamine, or just drop off of giving it to them for whatever reason, I see them fall back pretty quickly. And when I restart them on it, I notice a response in a few days. I also give give them…
1. The amount and frequency of glucosamine you give to your dog
2. The size of your dog (kg/pound)