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Glucosamine Supplementation Reduces All-Cause Mortality: Study

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Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#71

Post by dogma1138 »

NickM wrote: post #30
brownbat wrote: post #12

Earlier quoted context omitted.

> Edit: Yea, reading the study, I don't see anything about controlling for fitness level. They specifically control for the following lifestyle factors: "smoking status, alcohol consumption, physical activity, body mass index (BMI) and vegetable and fruit consumption." (Ctrl+f for "covariates") In the conclusion, they acknowledge: "Although we had carefully adjusted for potential confounding lifestyle-related factors…

But if someone "works out heavily and supplements," that should show up in self reported physical activity, and indirectly in BMI. Well, not to nitpick, but people with high muscle mass can easily end up with an "obese" BMI even if they have very low body fat. And it also doesn't take very many hours of working out per week to get jacked if you're doing heavy weightlifting and supplementing. No idea if such people ar…

Even body builders will have a hard time of getting to obese levels of BMI most of them are in the “overweight” range usually around 26-27.

And no people like this aren’t common at all.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#74

Post by hkt »

evo_9 wrote: post #55

If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews, I can't recommend Dr Stanfields youtube channel high enough: https://www.youtube.com/c/DrBradStanfield/videos Also here is his video on Sulforaphane which Glucosamine activates. He goes into detail as to how this mechanism works. Because of his video/latest…

Is a Cochrane review really a primary source? They're meta-analysis, which I'd think of as secondary.

In the case linked, the analysis seems pretty unequivocally to not support supplementing:

"We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be considered as medicinal products and should undergo sufficient evaluation before marketing."

Did I miss something?

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#75

Post by hkt »

oehtXRwMkIs wrote: post #72

It's interesting to see that even on HN people don't know the difference between correlation and causation.

I'd guess there's not much cause for it among computer science people. I've noticed this in the past: empirical disciplines are better at this stuff.

Still, I can't quite work out if a biology degree would cause somebody to understand it better..

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#76

Post by oehtXRwMkIs »

hkt wrote: post #75
oehtXRwMkIs wrote: post #72

It's interesting to see that even on HN people don't know the difference between correlation and causation.

I'd guess there's not much cause for it among computer science people. I've noticed this in the past: empirical disciplines are better at this stuff. Still, I can't quite work out if a biology degree would cause somebody to understand it better..

In my experience, most empirical majors beat you over the head with the chanting of "correlation does not imply causation" pretty much every term. It's too bad that it's one of those things that's not naturally intuitive to people.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#77

Post by Dayshine »

oehtXRwMkIs wrote: post #72

It's interesting to see that even on HN people don't know the difference between correlation and causation.

Have you read the paper? They adjust for damn near everything including reverse causation. What confounders do you believe the UK biobank data can't account for?

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#78

Post by bitxbit »

shadykiller wrote: post #73

Quote: "Glucosamine is a polysaccharide that is found naturally in cartilaginous joint tissues, bones, skin, ligaments, and nails" Why not just eat natural sources like cartilage, bone broth, skin etc ?

This so much. Absorption rate could vary quite a bit and it’s nearly impossible to research and find a good source these days due to insane number of supplement manufacturers in the market (I partly blame Amazon for this).

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#79

Post by jiggawatts »

ve55 wrote: post #24

I've been supplementing glucosamine along with a large amount of other things for awhile now. I'm not too bullish on it in humans, but it doesn't seem like it hurts, and is definitely cheap: https://nearcyan.com/supplements My latest favorites that I'm a bit more hopeful for are glycine, spermadine, and rapamycin.

On Rapamycin: "The known adverse effects caused by sirolimus and marketed analogs at the doses used in transplant regimens, especially the increased risk of infection due to immunosuppression, as well as dose-dependent metabolic impairment, make it unlikely that chronic, long-term treatment with sirolimus could become a widely used anti-aging agent."

Sounds more than a little dangerous, unless you have an illnes like Lupus that activates mTOR, and even then I'd be nervous taking this drug without expert medical supervision!

On the upside, my partner has a Lupus-like autoimmune disease, so this drug will be an interesting one to track.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#80

Post by DiabloD3 »

hkt wrote: post #74
evo_9 wrote: post #55

If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews, I can't recommend Dr Stanfields youtube channel high enough: https://www.youtube.com/c/DrBradStanfield/videos Also here is his video on Sulforaphane which Glucosamine activates. He goes into detail as to how this mechanism works. Because of his video/latest…

Is a Cochrane review really a primary source? They're meta-analysis, which I'd think of as secondary. In the case linked, the analysis seems pretty unequivocally to not support supplementing: "We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A. Antioxidant supplements need to be consi…

Vitamin E research also ends up being a bit YMMV: most commercially available Vitamin E is one form only, alpha tocopherol... except Vit E is 8 different forms: 4 tocopherols and 4 tocotrienols.

The research that has been done so far basically indicates alpha tocopherol-only supplementation aligns identically with unspecified-Vitamin-E-is-bad research.

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